| Silva GL et al. (2021) |
Randomized controlled clinical-intervention study |
Wound type:
Chronic venous ulcer.
Population sample:
39 adults, regardless of sex.
Groups:
Experimental groups (EG) 19 patients, treated with BC dressing; Control group (CG) 20 patients. |
Followed for 180 days, evaluated according to the MEASURE methodology. |
Evaluate the effectiveness of treatment for chronic venous ulcer of the lower limbs. |
In both groups, the wound area significantly decreased (p<0.001) and the healing rate was similar to the CG’s. The mean number of dressing changes in the EG was 18.33 ± 11.78, while in the CG it was 55.24 ± 25.81, p<0.001. |
The dressing made of bacterial cellulose, gel, and associated film, by stimulating the epithelialization of the lesions, showed a significant reduction in the initial area, with a cure rate like that of the Rayon® dressing, in addition to requiring less direct manipulation of the ulcers. |
| Maia AL et al. (2019) |
Randomized clinical trial. |
Wound type:
Arterial ulcer/ischemic wound.
Population sample:
24 patients after lower limb revascularization.
Groups:
Experimental Group (13 patients) treated with bacterial cellulose biopolymer film and gel.
Control Group (11 patients) treated with essential fatty acids. |
Followed for 90 days in weekly appointments to change dressings and evaluate healing process. |
To evaluate the use of a bacterial cellulose biopolymer film and gel dressing in the treatment of patients with ischemic wounds undergoing revascularization of the lower limbs. |
The reduction in the areas of ischemic wounds after 30 days was 4.3cm22 Chan B, Cadarette S, Wodchis W, Wong J, Mittmann N, Krahn M. Cost-of-illness studies in chronic ulcers: a systematic review. J Wound Care. 2017;26(sup4):S4-S14. doi: 10.12968/jowc.2017.26.Sup4.S4.
https://doi.org/10.12968/jowc.2017.26.Su...
(55%) on average for the experimental group and 5.5cm2 (48.5%) for the control one (p>0.05). The complete healing rate at 90 days was 34.8%, 50% in the experimental group and 18.2% in the control one (p=0.053). |
The bacterial cellulose biopolymer film associated with the gel can be used as a dressing in the treatment of ischemic wounds in patients undergoing revascularization of the lower limbs. |
| Author and year |
Type of study |
Population characteristics |
Follow-up time |
Goals |
Main results |
Conclusions |
| Cavalcanti LM et al. (2017) |
Prospective, randomized, controlled study. |
Wound type:
chronic venous ulcer
Population sample:
25 randomly assigned patients.
Groups:
Control group (11 patients) received dressings with triglyceride oil.
Experimental group (14 patients) treated with BC membrane (14 patients). |
Followed for a period of 120 days. |
To evaluate the effectiveness of dressings with Bacterial Cellulose membrane in the treatment of venous ulcers of the lower limbs. |
There was a reduction in wound area in both groups. There were no infections or reactions to the product in either group. Patients in the BC group showed a decrease in pain and earlier discontinuation of analgesics. |
The BC membrane can be used as a dressing for the treatment of varicose ulcers of the lower limbs. |
| Colenci R et al. (2019) |
Randomized, controlled clinical trial |
Wound type:
venous ulcer
Population sample:
Experimental group (25 patients with 37 ulcers in the biomembrane group).
Control group (21 with 36 ulcers treated with collagenase) |
Both groups received compression therapy. The primary outcome was ulcer area reduction at 90 days (T90). |
To evaluate the efficacy and safety of cellulose biomembranes in
comparison with the collagenase dressing for the treatment of venous ulcers.
|
In the primary outcome, there was a reduction in lesions’ area over time, but this difference was not significant between groups (at T90, p=0.66). Of the 73 ulcers, 19 ulcers healed, 12 (48%) in the biomembrane group and seven (33%) in the collagenase group (relative risk 1.4, 95% CI 0.7 3.0, p=0.30). There was no significant difference between groups. |
The reduction of VU area as a function of time was similar in biomembrane and collagenase dressings, with no significant difference between groups. However, the biomembranes promoted early wound healing and increased vascularity compared with collagenase. |
| Zanoti MDU et al. (2017) |
Quantitative, descriptive longitudinal study. |
Wound type:
venous ulcer, diabetic foot, and mixed wound.
Population sample:
14 patients (10 women and 4 men). |
Treatment was discontinued after complete healing or a maximum of 120 days, or when the patient changed his or her behavior at medical request or on his/her own accord. |
To describe the development of bacterial cellulose coating with anti-inflammatory Ibuprofen (BC/Ibu) and to evaluate the healing process with its use in patients with chronic wounds. |
There was a reduction in area and pain in nine lesions, total healing of three wounds, and debridement of devitalized tissue in five wounds with increased area. The use of the membrane decreased, pain, exudation, and facilitated performing the dressing. |
BC/Ibu favored the healing process of patients with chronic vasculogenic wounds. |
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