Experiments were carried out on mice, aiming to retard bowel movement in the descending colon. The microscopic alterations in the stools and the histopathological changes in the large intestine were observed. Fifteen male mice and fifteen female mice have been operated on and divided into three groups named 30, 60 and 90 days, according to the time set for the relaparotomy. All mice have been submitted to two extramucous seromytomies in the descending colon with circunferential incisions (360). One of them was located one centimeter; and the other two centimeters, above the peritoneal reflection. After the seromytomias, a seromuscular suture surrouding all over the colon area was performed. We observed visceral and perineal adherence in the three groups, the majority without organic repercurssion. However a mouse from the 60 days group had partial obstructive manifestation that resulted in death on the 40th pos-surgical day. There were complications with total colon obstruction for stools impact in the operated area of two female mice that also developed into death on the 2nd pos - surgical week. A mouse showed deiscence and evisceration of the abdominal suture, dying on the 10th day pos- surgical. Therefore, there were therefore four deaths (13,33%) due to a total, parcial and evisceration obstruction. In the three groups inflamatory reaction was observed, in all the coatings, which was greater in the 30 days groups. 1n the groups 60 and 90 days, sectionalized tissues were repaired by fibrous conjunctive tissue. Our results did not show that the procedure hasn't produced clinics and radiological repercussions, in the distal from the operated site intestine. There were histopathlogical alterations that assured inflamatory process with reaction of strange body type in the sutured colon. This inflamatory process on a same transversal and circunferencial plane, provided a concentrica partial stenose resulting intestine transit delay confirmed by the shape, shine and stools aglomeration. We've concluded that extramucosal seromyotomy with seromuscular suture can be used as a surgical resource in order to retard the intestinal transit in mice.
Seromyotomy and seromuscular suturing; Colon; Constipation; Colostomy; Perineal colostomy