BACKGROUND: The aim of this experimental study was to observe the behavior of Tumor Necrosis Factor and C-Reative Protein in simultaneous colectomy plus hepatectomy. METHODS: In this experimental model, 40 Wistar rats underwent surgery. They were divided into four groups: the control group; group 1, rats submitted to hepatectomy to 70%; group 2, rats submitted to colectomy; and group 3, rats submitted simultaneously to both procedures: hepatectomy plus colectomy. In all groups, TNF and PCR were collected one hour after the surgical procedure. The animals were killed afterwards. RESULTS: The dosage of these elements showed values with some alterations in all groups. Group three showed a significant increase of TNFalpha and decrease of PCR. CONCLUSION: The more complex became the surgical act the blood levels of TFNalpha have increased and the levels of the PCR decreased significantly.
Colorectal neoplasms; Hepatectomy; Colectomy; Tumor necrosis factor; Protein C; Rats, Wistar
