The bone densitometry is normal in Turner syndrome prepubertal patients after height age correction

Dallago, Renata Thomazini; Marmo, Denise Barbieri; Morcillo, André Moreno; Guerra Júnior, Gil; Santos, Allan de Oliveira; Galon, Marcus Vinicius; Lemos-Marini, Sofia Helena Valente de

doi:10.1590/1806-93042021000400010

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Revista Brasileira de Saúde Materno Infantil

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ORIGINAL ARTICLES • Rev. Bras. Saude Mater. Infant. 21 (4) • Oct-Dec 2021 • https://doi.org/10.1590/1806-93042021000400010 copy

The bone densitometry is normal in Turner syndrome prepubertal patients after height age correction

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Objectives:

to evaluate the bone mass in prepubertal patients with Turner Syndrome (TS) according to height age (HA) and verify the influence of karyotype and adiposity.

Methods:

retrospective and analytical study of prepubertal TS patients. The variables analyzed were: karyotype, age at bone densitometry (BD), height, body mass index (BMI) and BD result. The result of the BD was corrected using HA. BMI and BD were calculated on Z score for chronological age (CA) and for HA.

Results:

thirty-seven prepubertal patients were selected and after exclusion criteria, 13 cases between 10 and 13 years old were included in the study. The BD for HA was significantly higher than for CA (0.39 ± 1.18 x −1.62 ± 1.32), without karyotype (p=0.369) and BMI (p=0.697) influence.

Conclusion:

prepubertal TS patients present normal BD when corrected for HA, without influence of karyotype and BMI.

Key words:
Turner syndrome; Bone density; Densitometry

	Age (years)		BD (Z-score)
	CA	HA	CA	HA
Average	12.54	9.05	−1.62	0.39
Minimum	10.00	7.40	−3.90	−2.00
Maximum	13.90	11.00	0.70	2.40
Median			−1.50	0.70
p	0.001 (teste de Wilconox)		<0.001 (teste de Wilconox)

Karyotype	Distribution of bone densitometry in relation to karyotype
45,X	Z_BMD CA*	Z_BMD HA**
N	6	6
Average	−1.48	0.70
Minimum	−2.90	−0.10
Median	−1.40	0.80
Maximum	0.70	1.40
Standard deviation	1.25	0.51
Mosaicism
N	7	7
Average	−1.74	0.13
Minimum	−3.90	−2.00
Median	−1.80	0.30
Maximum	0.20	2.40
Standard deviation	1.46	1.54

Median Z_BMI	Distribution of BD in relation to BMI using as a cutoff point the median=0.61 for CA and HA
>0.61	Z BMD CA*	Z BMD HA**
N	6	6
Average	−1.48	0.63
Minimum	−2.50	−0.10
Median	−1.45	0.75
Maximum	0.720	1.20
Standard deviation	0.76	0.46
≤0.61
N	7	7
Average	−1.74	0.19
Minimum	−3.90	−2.00
Median	−1.80	0.40
Maximum	0.70	2.40
Standard deviation	1.72	1.57

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[1] Authors’ contribution

Dallago RT, Lemos-Marini SHV and Guerra-Junior G contributed to the planning, preparation and review of the study. Data collection was performed by Dallago RT, Marmos DB and Galon MV. Morcillo AM assisted in the statistical analysis. For help with techniques and with the densitometry device, we have the collaboration of Santos AO. The manuscript was written and revised by Dallago RT and Lemos-Marini SHV. All authors approved the final version of the manuscript and are publicly responsible for the content of the article.