Lanzillo et al., 1998 |
NCS of peripheral nerves |
40 RA patients |
5 (12.5%) |
Age, disease duration, steroid therapy, functional stage |
The electrophysiologic findings were unrelated to clinical features of RA. |
Sivri et al., 1999 |
NCS and somatosensorial evoked potential studies |
33 RA patients and 20 healthy controls |
2 (6%) |
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No correlation between neuropathy and the clinical variables. |
Sakini et al., 2005 |
NCS, EMG |
80 RA patients |
8 (22.8%) |
Disease duration |
There was no association between disease duration and the occurrence of neuropathy. |
Hammer et al., 2006 |
US of the median nerves at the entrance of the carpal tunnel, NCS, Tinel's and Phalen's tests. |
7 RA patients with CTS symptoms 5 patients with other forms of arthritis with CTS symptoms Controls: 30 RA patients without symptoms of CTS & 30 healthy controls |
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Height, weight |
CSA of the median nerves were significantly higher in the CTS patients compared with the RA controls and healthy persons; median (range) areas were 15.7 mm2 (11.1-21.8), 8.5 mm2 (5.8-11.0) and 8.0 mm2 (4.9-12.0), respectively (p < 0.0001). No significant correlation between CSA of median nerve and clinical parameters in the RA group. Healthy controls had significant correlation between CSA of median nerve and height (r = 0.6, p < 0.001) and weight (r = 0.43, p = 0.001) |
Agarwal et al., 2008 |
NCS of peripheral nerves |
108 RA patients |
11 (10.1%) |
Absence of deep tendon jerks, extra-articular manifestations (interstitial lung disease, vasculitis, subcutaneous nodules), disease duration, RF, joint erosions, joint deformities, DMARDs or glucocorticoid intake, and disease activity, abdominal fat pad for amyloid |
Absence of deep tendon jerks (p < 0.005) and vasculitis (p < 0.01) were conspicuous in the neuropathic group. There was no relationship between neuropathy and other parameters. |
Aktekin et al., 2009 |
EMG and NCS of the peripheral nerves |
56 RA patients 32 healthy controls |
2 (4%) |
Corticosteroid therapy, Schirmer's test, RF, disease activity |
There was no correlation between electrophysiologic findings and the other study parameters. |
Biswas et al., 2011 |
NCS of the peripheral nerves |
74 RA patients |
3 (10.3) |
Age, disease duration, disease activity, RF, interstitial lung disease, subcutaneous nodules, vasculitis, corticosteroids, DMARDs and joint erosions |
Disease duration and RF positivity was significantly higher in patients with neuropathy (p = 0.001 for both). No significant difference in other parameters between patients with and without neuropathy. |
Calder et al., 2012 |
NCS of the peripheral nerves, sensory mapping (SM), vibratory and current perception thresholds (VPT and CPT) of the 2nd and 5th digits |
7 women with RA 9 healthy women 11 women with hand OA |
|
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All SNAP amplitudes were significantly lower for the hand OA and hand RA groups compared with the healthy group (p < 0.05). No group differences were found for SNAP conduction velocities, SM, VPT, and CPT. |
Karadag et al., 2012 |
Katz hand diagram, Boston CTS questionnaire, Phalen and Tinel tests. US of wrist joints and carpal tunnel gray scale and power Doppler. Patients with median nerve CSA between 10.0 and 13.0 mm2 were evaluated with electromyography (EMG) |
100 RA patients 45 healthy controls |
18 (18%) |
Age, gender, body mass index, disease duration, goiter, disease activity, HAQ-DI, ESR, CRP, CTS global assessment, CTS symptom duration, Boston symptom severity score, Boston functional status |
In RA group with CTS: age (57 [36-73] vs. 50 [24-76], p = 0.041), history of DM (35.3% vs. 6.0%, p < 0.001), disease duration (108 [12-396] months vs. 72 [6-360] months, p = 0.036), HAQ-DI score (1.93 [0.75-2.87] vs. 1.13 [0-2.75], p = 0.013), CTS patient global score (52 [1-97] vs. 25 [0-91], p = 0.001), Boston symptom severity (2.81 [1.18-4.17] vs. 2.0 [1.0-4.01], p = 0.01) and functional status scores (3.37 [1.37-5.0] vs. 2.25 [1.0-5.0], p = 0.008) were elevated compared to patients without CTS. |
Sim et al., 2014 |
NCS, Neuropathic Symptoms Scale (NSS) |
30 RA patients with symptoms of peripheral neuropathy |
7 (23.3%) |
Age, anti-CCP, the type of medication, disease duration, functional status, neuropathic symptoms, ESR, CRP |
The mean ages of the patients with and without peripheral neuropathy were 69.4 and 56.5 years, respectively (p < 0.05). |
Lee et al., 2015 |
EMG, NCS, Phalen's and Tinel's tests |
1070 RA patients |
37 (3.5%) |
CRP, disease duration |
There was no statistically significant correlation between CTS occurrence and duration of RA and CRP levels. |