Olanzapine and quetiapine in the prevention of a new mood episode in women with bipolar disorder during the postpartum period: a retrospective cohort study

Uguz, Faruk; Kirkas, Aysegul

doi:10.1590/1516-4446-2020-1629

Acessibilidade / Reportar erro

Brasil

Brazilian Journal of Psychiatry

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

BRIEF COMMUNICATION • Braz J Psychiatry 43 (6) • Nov-Dec 2021 • https://doi.org/10.1590/1516-4446-2020-1629 copy

Olanzapine and quetiapine in the prevention of a new mood episode in women with bipolar disorder during the postpartum period: a retrospective cohort study

Authorship SCIMAGO INSTITUTIONS RANKINGS

Objective:

To examine whether olanzapine and quetiapine are useful in the prevention of a new mood episode during the postpartum period.

Methods:

Data on 23 patients (n=14 for olanzapine and n=9 for quetiapine) with bipolar disorder who met the criteria for this study were retrospectively gathered. The diagnosis of bipolar disorder was determined by means of the DSM-IV.

Results:

The mean follow-up period was 33.95±12.07 weeks. Six (26.1%) of 23 patients experienced recurrent mood episodes during the postpartum period. Four of these six patients were taking olanzapine and two were taking quetiapine. Patients with recurrent mood episodes had a significantly stronger family history of bipolar disorder, higher number of past episodes, and earlier onset and longer duration of illness compared to patients without recurrent mood episodes.

Conclusion:

Monotherapy with olanzapine or quetiapine can be considered as an alternative to mood stabilizers in preventing the development of new mood episodes after childbirth.

Postpartum period; olanzapine; quetiapine; bipolar disorder

	Women with a new mood episode n=6	Women without a new mood episode n=17	p-value
Age at assessment, mean ± SD, years	31.83±2.31	29.88±4.91	0.365^* * t test; † χ2 test; ‡ Fisher’s exact test.
Age at disorder onset, mean ± SD, years	19.66±2.06	24.06±4.64	0.038^* * t test; † χ2 test; ‡ Fisher’s exact test.
Duration of disorder, mean ± SD, years	11.83±3.06	5.94±3.83	0.003^* * t test; † χ2 test; ‡ Fisher’s exact test.
Number of previous mood episodes, mean ± SD	4.17±1.94	2.53±1.28	0.028^* * t test; † χ2 test; ‡ Fisher’s exact test.
Education, n (%)			0.424^†
Primary	5 (83.3)	11 (64.7)
Secondary	0 (0)	4 (23.5)
Higher	1 (16.7)	2 (11.8)
Employment status, n (%)			1.000^‡
Unemployed	6 (100)	15 (88.2)
Primiparity, n (%)	2 (33.3)	8 (47.1)	0.660^‡
Family history of BD, n (%)	4 (66.7)	3 (17.6)	0.045^‡
Type of BD, n (%)			1.000^‡
I	4 (66.7)	12 (70.6)
II	2 (33.3)	5 (29.4)
Mood episode during last pregnancy	2 (33.3)	2 (14.3)	0.549^‡

	Women with a new mood episode n=6	Women without a new mood episode n=17	p-value
Age at assessment, mean ± SD, years	31.83±2.31	29.88±4.91	0.365^* * t test;
Age at disorder onset, mean ± SD, years	19.66±2.06	24.06±4.64	0.038^* * t test;
Duration of disorder, mean ± SD, years	11.83±3.06	5.94±3.83	0.003^* * t test;
Number of previous mood episodes, mean ± SD	4.17±1.94	2.53±1.28	0.028^* * t test;
Education, n (%)			0.424^† † χ2 test;
Primary	5 (83.3)	11 (64.7)
Secondary	0 (0)	4 (23.5)
Higher	1 (16.7)	2 (11.8)
Employment status, n (%)			1.000^‡ ‡ Fisher’s exact test.
Unemployed	6 (100)	15 (88.2)
Primiparity, n (%)	2 (33.3)	8 (47.1)	0.660^‡ ‡ Fisher’s exact test.
Family history of BD, n (%)	4 (66.7)	3 (17.6)	0.045^‡ ‡ Fisher’s exact test.
Type of BD, n (%)			1.000^‡ ‡ Fisher’s exact test.
I	4 (66.7)	12 (70.6)
II	2 (33.3)	5 (29.4)
Mood episode during last pregnancy	2 (33.3)	2 (14.3)	0.549^‡ ‡ Fisher’s exact test.

Associação Brasileira de Psiquiatria Rua Pedro de Toledo, 967 - casa 1, 04039-032 São Paulo SP Brazil, Tel.: +55 11 5081-6799, Fax: +55 11 3384-6799, Fax: +55 11 5579-6210 - São Paulo - SP - Brazil
E-mail: editorial@abp.org.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Correspondence: Faruk Uguz, Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, Psikiyatri Anabilim Dali, Meram, 42080, Konya, Turkey. E-mail: farukuguz@gmail.com