Influence of Hypovitaminosis D on the Ocurrence of Fractures

A primary, analytical, cross-sectional, non-interventional, observational, controlled study was conducted in humans. The serum measurement of: vitamin D, parathyroid hormone (PTH), calcium, phosphorus, magnesium and albumin was performed in 49 patients who were consecutively hospitalized for surgery due to fracture(s) (study group), and in 50 patients without fractures, from the various outpatient clinics, and who underwent routine tests (control group).

Results

The mean level of 25-hydroxyvitaminD (25[OH]D) in patients with fractures was of 23.78 ± 8.01 ng/mL (61.22% of patients with fractures had hypovitaminosis D). The mean 25(OH)D of the control group was of 37.52 ± 9.21 ng/mL (10% of the patients had hypovitaminosis D). Most cases of hypovitaminosis (96%) did not course with secondary hyperparathyroidism (mean PTH = 41.80 ± 22.75 pg/mL).

Conclusion

Hypovitaminosis D was found in a significant percentage (61.22%) of the patients who suffered fractures. Further studies on the subject are needed to better understand the influence of hypovitaminosis D on the occurrence of fractures, as well as the benefits of vitamin D supplementation in these patients.

Keywords
vitamin D; vitamin D deficiency; osteoporosis; hip fractures; fracture healing

	Group	N	Mean	Standard deviation	Minimum	Maximum	p
Age	Control	50	50.40	21.3	20	89
							0.983
	Study	49	50.30	21.5	18	90
Body mass index	Control	50	26.13	3.69	18.39	35.1
							0.289
	Study	49	27.10	5.19	18.13	45.49

Group	Male	Female	Total	p
Study	31 (63%)	18 (37%)	49 (100%)	0.150
Control	25 (50%)	25 (50%)	50 (100%)

Protection against the sun	Control	Study	p
No	23	23
Sunscreen and/or clothing	27	26	1
Only sunscreen	0	0
Total	50	49
Smoking
Yes	10	12
No	40	37	0.483
Total	50	49
Exposure to the sun
Daily	37	32
Occasional	13	19	1
Total	50	49

Groups	N	Mean (ng/mL)	Standard deviation	p
Study	49	23.78	8.01	0.00^* * Statistical significance.
Control	50	37.52	9.21

N (STUDY + CONTROL)	Spearman r	p
99	0.668	0.00^* * Statistical significance.

Sociedade Brasileira de Ortopedia e Traumatologia Al. Lorena, 427 14º andar, 01424-000 São Paulo - SP - Brasil, Tel.: 55 11 2137-5400 - São Paulo - SP - Brazil
E-mail: rbo@sbot.org.br

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[1] *
Work developed at the Department of Orthopedics and Traumatology, Hospital das Clínicas Samuel Libânio, Pouso Alegre, Minas Gerais, MG, Brazil.

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Influence of Hypovitaminosis D on the Ocurrence of Fractures* * Work developed at the Department of Orthopedics and Traumatology, Hospital das Clínicas Samuel Libânio, Pouso Alegre, Minas Gerais, MG, Brazil.

Abstract

Objective

Methods

Results

Conclusion

Influence of Hypovitaminosis D on the Ocurrence of Fractures^* * Work developed at the Department of Orthopedics and Traumatology, Hospital das Clínicas Samuel Libânio, Pouso Alegre, Minas Gerais, MG, Brazil.