PURPOSE: Demonstrate the possibility of changing the biomechanical behaviour of cornea stroma by usage of riboflavin associated with non-ultraviolet light. METHODS: Double blind prospective study. Twenty five porcine eyes enucleated 24 hours before the experiment, have been divided on the following groups : Riboflavin 0,1% with irradiation of blue light, Riboflavin 0,1% without irradiation of light , Riboflavin 0,5% with irradiation of blue light, Riboflavin 0,5% without irradiation of light and BSS with irradiation of light. RESULTS: Differences where noticed in groups 1 and 3 (p<0,05). The groups without irradiation and the group with only irradiation, had no significant difference on their results. CONCLUSION: The usage of riboflavin appears to increase the crosslink connections among collagen fibrills. On the studied concentrations studied and radiant parameters the increase of biomechanical characteristics of cornea have been obtained successfully.
Riboflavin; Photosensitizing agents; Corneal stroma; Photochemistry; Biomechanics; Photobleaching; Ultraviolet rays; Swine
