Hypogamaglobulinemia is frequently associated with B-CLL rendering the patients prone to bacterial infections. The use of purine analogs that cause depletion of T lymphocytes in the treatment of this disease, increases the spectrum of susceptibility of these patients to oportunistic agents. We report a case of a young B-CLL patient treated with 2-CdA, who presented multiple infectious complications during the course of his disease associated with a severe cellular immune deficiency.
Chronic lymphocityc leukemia; cryptococcal meningitis; cladribine