Angiolymphoid hyperplasia (Hale) and Kimura disease are two entities that can manifest as subcutaneous nodules, plaques, or papules, and the predominant localization is face, retroauricular and cervical region. They are rare causes of eosinophilia and there is discussion regarding their etiopathogenesis. Some authors propose that these two diseases are truly individual, but others say that they are separate points on a single spectrum. This article is a case report of an asian patient that showed a one year duration of generalized pruritus, with papules on the limbs and a 5 centimeter nodule on the right retroauricular region with slow progression of the size. The hemogram showed leucocitosis with eosinophilia. These findings suggest an overlap between these two diseases, they are clinically suggestive of Kimura disease diagnosis, but the histopathology with HE and immunohistochemistry confirmed the endothelial origin of the lesion that was compatible with Hale. The authors emphasize the rarity of the case as the cause of eosinophilia, also alert for the challenge of the diagnosis and distinction between these two diseases.
Eosinophilia; angiolymphoid hyperplasia with eosinophilia; Kimura disease
