Untargeted evaluations
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Dessì et al (2011)1010 Dessì A, Atzori L, Noto A, et al. Metabolomics in newborns with intrauterine growth retardation (IUGR): urine reveals markers of metabolic syndrome. J Matern Fetal Neonatal Med 2011;24 (Suppl 2):35-39. Doi: 10.3109/14767058.2011.605868 https://doi.org/10.3109/14767058.2011.60...
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Italy |
Urine |
< 24h after birth (before any nutrition)/ again 96h after birth |
H-NMR |
|
IUGR: < 10th centile of BW by populational curves suspected in pregnancy |
26 IUGRb30 AGA, preterm births |
Creatinine and myo-inositol |
|
Horgan et al (2011)1515 Horgan RP, Broadhurst DI, Walsh SK, et al. Metabolic profiling uncovers a phenotypic signature of small for gestational age in early pregnancy. J Proteome Res 2011;10(08):3660-3673. Doi: 10.1021/pr2002897 https://doi.org/10.1021/pr2002897...
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Australia |
Blood |
20' after birth |
UPLC-MS |
|
< 10th centile customized birth weight |
8 SGA6 AGA |
DG (32:0) |
Phenylacetylglutamin, leucyl-leucyl-norleucine, cervonyl-carnitine, (15Z)-tetra-cosenoic acid, hexacosanedioic acid, pentacosenoic acid, cycloheptanecarboxylic acid, hydroxybutyrate, lysoPC (18:2), PC-more than 20 hits, PC, lyso-PC, acetylleucyl-leucyl-norleucinal, lysoPC(16:1), pregnanediol-3-glucuronide, sphinganine 1-phosphate, sphingosine 1-phosphate, pregnanediol-3-glucuronide, 6-hydroxysphingosine |
Favretto et al (2012)1111 Favretto D, Cosmi E, Ragazzi E, et al. Cord blood metabolomic profiling in intrauterine growth restriction. Anal Bioanal Chem 2012;402(03):1109-1121. Doi: 10.1007/s00216-011-5540-z https://doi.org/10.1007/s00216-011-5540-...
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Italy |
Venous cord blood |
Immediately after birth |
Metabolic profiling/LC-HRMS |
|
IUGRa: EFW < 10thcentile AGA: EFW 10-90th centile – both confirmed after birth by populational curves |
22 IUGR21 AGA; antepartum C-section. |
Tryptophan, phenylalanine, glutamate, valine, isoleucine, histidine, proline,methionine, dopamine, uric acid, 5-methylundecenoic acid, L-thyronine, hexadecanedioic acid, (OH)VitD3-3-D-glucopyranoside |
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Sanz-Cortés et al (2013)1212 Sanz-Cortés M, Carbajo RJ, Crispi F, Figueras F, Pineda-Lucena A, Gratacós E. Metabolomic profile of umbilical cord blood plasma from early and late intrauterine growth restricted (IUGR) neonates with and without signs of brain vasodilation. PLoS One2013;8(12):e80121. Doi: 10.1371/journal.pone.0080121 https://doi.org/10.1371/journal.pone.008...
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|
Venous cord blood |
At delivery |
H-NMR |
|
IUGR: < 10th centile of BW and Doppler abnormalities |
76 IUGRa55 AGAd
|
Unsaturated lipids, creatine, glutamine |
Choline |
Dessì et al (2014)3838 Dessì A, Marincola FC, Pattumelli MG, et al. Investigation of the 1H-NMR based urine metabolomic profiles of IUGR, LGA and AGA newborns on the first day of life. J Matern Fetal Neonatal Med 2014;27(Suppl 2):13-19. Doi: 10.3109/14767058.2014.955674 https://doi.org/10.3109/14767058.2014.95...
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Italy |
Urine |
1st urine after birth |
H-NMR |
|
IUGR: < 10th centile of BW by populational curves suspected in pregnancy |
12 IUGRb17 AGA |
Citrate, creatinine, creatine, myo-inositol, betaine/TMAO, glycine |
Urea, aromatic, compounds, branched-chain amino acids |
Miranda et al (2018)1313 Miranda J, Simões RV, Paules C, et al. Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction. Sci Rep 2018;8 (01):13614. Doi: 10.1038/s41598-018-31832-5 https://doi.org/10.1038/s41598-018-31832...
|
Spain |
Blood |
After birth |
H-NRM |
FGR: EFW <3rd centile or <10th+ Doppler abnormalitiesSGA: EFW and BW <10th without Doppler abnormalities |
|
|
Fatty acids, formate (SGAxAGA/FGRxAGA)Acetate (FGRxAGA) |
|
Targeted evaluations
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Liu et al (2016)3939 Liu J, Chen XX, Li XW, Fu W, Zhang WQ. Metabolomic research on newborn infants with intrauterine growth restriction. Medicine (Baltimore) 2016;95(17):e3564. Doi: 10.1097/MD.0000000000003564 https://doi.org/10.1097/MD.0000000000003...
|
China |
Blood |
3-7 days of birth |
HPLC-MS |
21 amino acids and 55 acylcarnitines |
IUGR: < 10th percentile of BW by populational curves |
60 IUGRa60 AGA |
|
Alanine, homocysteine, methionine, ornithine, serine, tyrosinec
|
Visentin et al (2017)1414 Visentin S, Crotti S, Donazzolo E, et al. Medium chain fatty acids in intrauterine growth restricted and small for gestational age pregnancies. Metabolomics 2017;13(05):1-9. Doi: 10.1007/s11306-017-1197-8 https://doi.org/10.1007/s11306-017-1197-...
|
Italy |
Venous cord blood |
At birth |
GC-MS |
Medium chain fatty acids |
IUGR: EFW < 3rd centile or <10th centile + Doppler abnormalitiesSGA: EFW and BW < 10th without Doppler abnormalities |
11 IUGR12 AGA10 SGA |
Decanoic and dodecanoic acids (SGA x IUGR)octanoic, decanoic and dodecanoic acids (SGA x AGA) |
|