The present work evaluated the antinociceptive and anti-inflammatory activities of the essential oil from barks of Duguetia lanceolata. For this purpose, acetic acid writhing, formalin and carrageenan tests were performed. The number of writhings (ED50 = 21,79 mg/kg) and the lick of the paw 1st phase (ED50 = 5,27 mg/kg) e 2nd phase (ED50 = 1,43 mg/kg) reduced significantly in a dosedependent form. The doses 50, 100 and 200 mg/kg reduced the paw edema significantly in 20,83; 36,46 and 48,96%, respectively. These results suggest that the essential oil from barks of D. lanceolata has antinociceptive and anti-inflammatory effects and probably the mechanisms(s) involve central and peripheric actions.