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Original articles • Rev. bras. farmacogn. 29 (04) • Jul-Aug 2019 • https://doi.org/10.1016/j.bjp.2019.02.008   copy

In-vitro cardiovascular protective activity of a new achillinoside from Achillea alpina

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Achillinoside was isolated from methanol extract of Achillea alpina L., Asteraceae. The structure of the compound was characterized based on various spectrum data, including IR, HR-ESI-MS, 1D and 2D NMR. The cardiovascular protective effect of achillinoside was tested on H2O2-induced H9c2 cells. In our research, achillinoside could increase the cell viability dose-dependently in H2O2-induced H9c2 cells. In addition, the levels of caspase-3/9 cells were significantly decreased in H2O2 and achillinoside incubated H9c2 cells.

Keywords:
Achillinoside; Apoptosis inhibition; Spectroscopic analysis; H9c2 cells

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