| Xiang et al.11 Xiang F, Song HP, Huang YS. Clinical features and treatment of 140 cases of Marjolin’s ulcer at a major burn center in southwest China. Exp Ther Med. 2019;17(5):3403-10.
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Clinical features and treatment of 140 cases of Marjolin's ulcer at a major burn center in southwest China |
2019 |
MU occurred mainly in men and resulted from scar carcinoma after burns. The pathological type was mainly squamous cell carcinoma. Autologous skin grafting and local skin flap repair were the main repair methods used. The skull bone was the site most susceptible to invasion. |
Retrospective Study |
| Bang & Woo22 Bang CY, Woo S. The Fate of Chronic Burn Wounds Suspected as Marjolin’s Ulcers. J Burn Care Res. 2018;39(1):148-53.
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The Fate of Chronic Burn Wounds Suspected as Marjolin's Ulcers |
2018 |
Histologically, chronic ulcer and pseudoepitheliomatous hyperplasia were 21%, respectively, and malignancy, including squamous cell carcinoma and leiomyosarcoma, was 58%. The mean latency period was 31.6±13.0 years, and most injuries occurred in the extremities. |
Retrospective Study |
| Kerr-Valentic et al.33 Kerr-Valentic MA, Samimi K, Rohlen BH, Agarwal JP, Rockwell WB. Marjolin’s ulcer: modern analysis of an ancient problem. Plast Reconstr Surg. 2009;123(1):184-91.
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Marjolin's Ulcer: modern analysis of an ancient problem |
2009 |
Although burn scarring represents 76.5% of patients in the authors' review, venous stasis ulcers, traumatic wounds, osteomyelitis, and pressure ulcers are also types of wounds that can undergo malignant degeneration. |
Cross-sectional study with bibliographic review |
| Choi et al.44 Choi JY, Bae YC, Nam SB, Bae SH. Impact of Disturbed Wound Healing after Surgery on the Prognosis of Marjolin’s Ulcer. Arch Plast Surg. 2013;40(3):198-202.
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Impact of Disturbed Wound Healing after Surgery on the Prognosis of Marjolin's Ulcer |
2013 |
The recurrence rate increases in patients with low histological grade or lymph node metastases at diagnosis. The recurrence rate is even higher when the problem occurs during wound healing after surgery. |
Retrospective Study |
| Calikapan et al.66 Calikapan GT, Akan M, Karaca M, Aköz T. Marjolin ulcer of the scalp: intruder of a burn scar. J Craniofac Surg. 2008;19(4):1020-5.
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Marjolin ulcer of the scalp: intruder of a burn scar |
2008 |
Consistent with the literature, the histopathology of the tumors was squamous cell carcinoma in most patients. Although rare, mesenchymal tumor is involved in 2 out of 9 patients. The latency period of the tumor is inversely proportional to the age at the time of the burn. |
Cross-sectional study |
| Serras et al.99 Serras RP, Rasteiro DC, Mendes MM, Mouzinho MM. Melanoma Marjolin’s ulcer in the hand: A case report. Int J Surg Case Rep. 2019;60:345-7.
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Melanoma Marjolin's ulcer in the hand: a case report |
2019 |
Female, 74 years old, with malignant melanoma resulting from a burn scar on the right thenar eminence 14 years after the initial lesion. The lesion was excised, and a full-thickness skin graft covered the defect. At 6 months postoperatively, there are no signs of locoregional recurrence or systemic dissemination. |
Case report |
| Xiao et al.1111 Xiao H, Deng K, Liu R, Chen Z, Lin Y, Gao Y, et al. A review of 31 cases of Marjolin’s ulcer on scalp: Is it necessary to preventively remove the scar? Int Wound J. 2019;16(2):479-85.
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A review of 31 cases of Marjolin's ulcer on the scalp: Is it necessary to preventively remove the scar? |
2019 |
Of the 31 patients with MU on the scalp, the mean latency and post-ulceration period was 42.9 years and 37.5 months, respectively. Among them, 30 patients were diagnosed with cancer 5 years after the initial lesion, and 25 experienced a pre-ulceration period of more than 20 years. A negative correlation was identified between the post-ulceration period of the scalp MU and its pre-ulceration period. |
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| Shen et al.1212 Shen R, Zhang J, Zhang F, DU Y, Liang W, Xu L, et al. Clinical characteristics and therapeutic analysis of 51 patients with Marjolin’s ulcers. Exp Ther Med. 2015;10(4):1364-74.
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Clinical characteristics and therapeutic analysis of 51 patients with Marjolin's ulcer |
2015 |
Among patients with squamous cell carcinoma, 30.23% had metastasis to the sentinel lymph node, and 11.63% had distant metastasis. Among patients with melanoma, 66.67% had sentinel lymph node metastases, and 33.33% had distant metastases. |
Retrospective Study |
| Costa et al.1010 Costa MP, Sturtz G, Costa FPP, Ferreira MC, Barros Filho TEP. Epidemiologia e tratamento das úlceras de pressão: experiência de 77 casos. Acta Ortop Bras. 2005;13(3):124-32.
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Epidemiology and treatment of pressure ulcers: experience of 77 cases |
2005 |
Forty-five patients with 77 ulcers were evaluated during this period. Regarding sex, a 4:1 male predominance was found. 32.47% of the ulcers were located in the sacral region, 32.47% in the trochanteric region, and 15.58% in the sciatic region. Mostly young (mean age 34.78 years), with spinal cord injuries (100% of patients), victims of firearm injuries (60% of patients), chronic (93.3%), and grade IV injuries ( 67.53%). |
Prospective Study |
