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Reconstruction of the abdominal wall in rats with hemicellulose

INTRODUCTION: Substance losses of abdominal wall (SLAW) has a vital clinical and surgical importance due to the high frequency which they occur, the suffering they cause, the challenge of treatment and the high cost of treatment administered today. In the last years, has been observed the development of new techniques to resolve SLAW, some which include the making of flaps and the use of biocompatible and synthetic materials. METHODS: This random experimental and uncontrolled study evaluated the use of hemicellulose as a repair of SLAW in 40 EPM III Wistar female rats. The animals were divided in four experimental study groups: I (n=10), II (n=10), III (n=10), IV (n=10). All the animals were submitted to general anesthesia using sodium thiopental, via intraperitoneal. A lesion of aponeurotic muscle tissue and peritoneal from the region anterior abdominal was made. The placing of hemicellulose pellicle over the lesion was performed overlapping fifteen pellicles (2.0 x 3.0 cm each), bathed in 0.9% saline solution. The pellicle was fixed to adjacent muscle wall, the subcutaneous and skin was sutured by continuous suturing with 5-0 nylon suture. The provoked death (euthanasia) of the animals in each group - I (n=10), II (n=10), III (n=10), IV (n=10) - was done after 3, 28, 35, and 240 days, respectively. CONCLUSION: The conclusion of this study expressed that hemicellulose pellicle was efficient in the repair of SLAW in rats.

Abdominal wall; Implants, experimental; Rats; Histology


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