| Almela et al.[6060 Almela P, Martínez-Laorden E, Atucha NM, Milanés MV, Laorden ML. Naloxone-precipitated morphine withdrawal evokes phosphorylation of heat shock protein 27 in rat heart through extracellular signal-regulated kinase. J Mol Cell Cardiol. 2011;51(1):129-39.]
|
To investigate the HSP27 expression during morphine dependence and withdrawal |
Morphine withdrawal ↑HSP27 in heart |
| Baba et al.[6262 Baba HA, Schmid KW, Schmid C, Blasius S, Heinecke A, Kerber S, et al. Possible relationship between heat shock protein 70, cardiac hemodynamics, and survival in the early period after heart transplantation. Transplantation. 1998;65(6):799-804.]
|
To determine the correlation between hemodynamic parameters and HSP70 in the early period after heart transplantation |
Worsening of the parameters is correlated with ↑HSP70 / Patients who died and in case of transplant rejection was observed more ↑HSP /
↑HSP70 was inversely correlated with rejection |
| Boluyt et al.[5959 Boluyt MO, Brevick JL, Rogers DS, Randall MJ, Scalia AF, Li ZB. Changes in the rat heart proteome induced by exercise training: Increased abundance of heat shock protein hsp20. Proteomics. 2006;6(10):3154-69.]
|
To determine the protein changes in the heart after physical training |
Chronic physical training ↑HSP20 / ↑HSP20 can stay up to 72h after physical training |
| Bonanad et al.[1616 Bonanad C, Núñez J, Sanchis J, Bodi V, Chaustre F, Chillet M, et al. Serum heat shock protein 60 in acute heart failure: a new biomarker? Congest Heart Fail. 2013;19(1):6-10.]
|
To evaluate the correlation between HSP60 and the risk of death/recurrence of acute HF |
↑HSP60 related to risk of death/recurrence |
| Chen et al.[2727 Chen H, Wu XJ, Lu XY, Zhu L, Wang LP, Yang HT, et al. Phosphorylated heat shock protein 27 is involved in enhanced heart tolerance to ischemia in short-term type 1 diabetic rats. Acta Pharmacol Sin. 2005;26(7):806-12.]
|
To investigate the response of HSPs and tolerance of type 1 diabetic hearts to ischemia/reperfusion injury |
↑HSP27 phosphorylated and ↑injury tolerance in diabetic hearts / ↔HSP70 in diabetic hearts |
| Comini et al.[4343 Tanonaka K, Toga W, Yoshida H, Takeo S. Myocardial heat shock protein changes in the failing heart following coronary artery ligation. Heart Lung Circ. 2003;12(1):60-5.]
|
To investigate the HSP70 expression in lungs, liver, cardiac and skeletal muscle in congestive heart failure |
CHF, but not compensatory hypertrophy ↑HSP70 in heart |
| Dohke et al.[5757 Dohke T, Wada A, Isono T, Fujii M, Yamamoto T, Tsutamoto T, et al. Proteomic analysis reveals significant alternations of cardiac small heat shock protein expression in congestive heart failure. J Card Fail. 2006;12(1):77-84.]
|
To evaluate the change of protein expression in HF |
↑HSP27 and ↑HSP20 in hearts with HF |
| Dybdahl et al.[4949 Dybdahl B, Wahba A, Lien E, Flo TH, Waage A, Qureshi N, et al. Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation. 2002;105(6):685-90.]
|
To explore the release of HSP70 after CABG |
↑HSP70 release after CABG / ↑HSP70 related to ↑IL-6 and ↑TNF |
| Efthymiou et al.[2525 Efthymiou CA, Mocanu MM, Belleroche J, Wells DJ, Latchmann DS, Yellon DM. Heat shock protein 27 protects the heart against myocardial infarction. Basic Res Cardiol. 2004;99(6):392-4.]
|
To investigate the heart response overexpressing HSP27 to ischemia/reperfusion injury |
↑HSP27 ↓the infarct size / ↑ HSP27 protected the heart from ischemia/reperfusion injury |
| Ferrari et al.[4242 Comini L, Gaia G, Curello S, Ceconi C, Pasini E, Benigno M, et al. Right heart failure chronically stimulates heat shock protein 72 in heart and liver but not in other tissues. Cardiovasc Res. 1996;31(6):882-90.]
|
To compare myocardial hibernation and congestive heart failure in HSP72 expression |
Myocardial hibernation ↑HSP72 in right and left ventricles / Congestive heart failure ↑HSP72 more marked in the right than in the left ventricle |
| Gauthaman et al.[2828 Gauthaman K, Banerjee SK, Dinda AK, Ghosh CC, Maulik SK. Terminalia arjuna (Roxb.) protects rabbit heart against ischemic-reperfusion injury: role of antioxidant enzymes and heat shock protein. J Ethnopharmacol. 2005;96(3):403-9.]
|
To investigate the effect of Terminalia arjuna (TA) on HSP expression and its influence on ischemic damage |
Terminalia arjuna treatment ↑HSP72 / Treatment ↑the recovery of cardiac function after ischemia/reperfusion |
| Genth-Zotz et al.[6565 Genth-Zotz S, Bolger AP, Kalra PR, von Haehling S, Doehner W, Coats AJ, et al. Heat shock protein 70 in patients with chronic heart failure: relation to disease severity and survival. Int J Cardiol. 2004;96(3):397-401.]
|
To investigate the circulating HSP70 levels in patients with CHF |
↑HSP70 in CHF patients / ↑HSP70 related to disease severity |
| Gombos et al.[6767 Gombos T, Förhécz Z, Pozsonyi Z, Jánoskuti L, Prohászka Z. Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure. Cell Stress Chaperones. 2008;13(2):199-206.]
|
To investigate the clinical and biological correlation of HSP70 in HF |
↑HSP70 levels were associated with disease severity in HF patients / ↑HSP70 correlated with markers of cardiac function and liver injury |
| Gray et al.[5151 Gray CC, Amrani M, Smolenski RT, Nakamura K, Yacoub MH. Cold cardioplegic arrest enhances heat shock protein 70 in the heat-shocked rat heart. J Thorac Cardiovasc Surg. 2001;121(6):1130-6.]
|
Investigate the effect of hypothermic cardioplegic arrest in the expression of HSP70 |
The hypothermic cardioplegic ↑HSP70 more than normothermic control |
| Hoppichler et al.[5656 Hoppichler F, Lechleitner M, Traweger C, Schett G, Dzien A, Sturm W, et al. Changes of serum antibodies to heat-shock protein 65 in coronary heart disease and acute myocardial infarction. Atherosclerosis. 1996;126(2):333-8.]
|
To investigate the association between HSP60 antibodies with coronary heart disease and acute myocardial infarction |
CHD ↓HSP60 / Myocardial infarction ↓HSP60 antibodies compared to CHD |
| Hu et al.[5858 Hu H, Wang L, Okauchi M, Keep RF, Xi G, Hua Y. Deferoxamine affects heat shock protein expression in heart after intracerebral hemorrhage in aged rats. Acta Neurochir Suppl. 2011;111:197-200.]
|
To examine the expression of HSPs in the heart after ICH |
ICH ↓HSP27 and ↓HSP32 in the heart |
| Jafarzadeh et al.[6868 Jafarzadeh A, Esmaeeli-Nadimi A, Shariati M. High sensitivity C-reactive protein and immunoglobulin G against Chlamydia pneumoniae and chlamydial heat shock protein-60 in ischemic heart disease. Iran J Immunol. 2008;5(1):51-6.]
|
To evaluate HSP60 in patients with ischemic heart disease |
↑HSP60 in the groups of patients compared to control groups |
| Jiang et al.[3333 Jiang B, Zhang B, Liang P, Chen G, Zhou B, Lv C, et al. Nucleolin protects the heart from ischaemia-reperfusion injury by up-regulating heat shock protein 32. Cardiovasc Res. 2013;99(1):92-101.]
|
To investigate the role of nucleolin in cardiac ischemia/reperfusion injury |
Nucleolin ↑HSP32 / ↑HSP32 offers cardiac protection |
| Katayose et al.[5252 Katayose D, Isoyama S, Fujita H, Shibahara S. Separate regulation of heme oxygenase and heat shock protein 70 mRNA expression in the rat heart by hemodynamic stress. Biochem Biophys Res Commun. 1993;191(2):587-94.]
|
To examine the expression of heme oxygenase (HSP32) and HSP70 in hearts subjected to hypoxia or pulmonary artery banding |
Hypoxia ↑HSP32 e ↔HSP70 in right and left ventricle / Pulmonary artery banding ↑HSP32 and ↑HSP70 |
| Kim et al.[2323 Kim SO, Baines CP, Critz SD, Pelech SL, Katz S, Downey JM, et al. Ischemia induced activation of heat shock protein 27 kinases and casein kinase 2 in the preconditioned rabbit heart. Biochem Cell Biol. 1999;77(6):559-67.]
|
To examine whether extracellular kinases are upregulated by preconditioning and whether they are required for cadioprotection |
Preconditioning ↑HSP27 and ↓infarct size |
| Knowlton and Sun[4747 Knowlton AA, Sun L. Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart. Am J Physiol Heart Circ Physiol. 2001;280(1):H455-64.]
|
To investigate the relationship between HSPs and hormone receptors |
17-B-estradiol or progesterone ↑HSF-1 and ↑HSP70 |
| Knowlton et al.[5353 Knowlton AA, Eberli FR, Brecher P, Romo GM, Owen A, Apstein CS. A single myocardial stretch or decreased systolic fiber shortening stimulates the expression of heat shock protein 70 in the isolated, erythrocyte-perfused rabbit heart. J Clin Invest. 1991;88(6):2018-25.]
|
To investigate the effect of decreased systolic shortening and a single stretch on HSP70 expression |
Single stretch and fiber shortening ↑HSP70 |
| Kohno et al.[3030 Kohno H, Takahashi N, Shinohara T, Ooie T, Yufu K, Nakagawa M, et al. Receptor-mediated suppression of cardiac heat-shock protein 72 expression by testosterone in male rat heart. Endocrinology. 2007;148(7):3148-55.]
|
To investigate the effects of testosterone on HSP72 expression and its relation to cardioprotection |
Exogenous testosterone ↓HSP72 after heat stress / ↑ HSP72 correlates ↓cardiac apoptosis and ↑functional recovery |
| Krishanarmurthy et al.[3131 Krishnamurthy K, Kanagasabai R, Druhan LJ, Ilangovan G. Heat shock protein 25-enriched plasma transfusion preconditions the heart against doxorubicin-induced dilated cardiomyopathy in mice. J Pharmacol Exp Ther. 2012;341(3):829-39.]
|
To determine the relationship between HSP25 and protection against cardiotoxicity |
↑HSP25 protected the heart from cardiotoxicity |
| Kukreja et al.[4141 Ferrari R, Bongrazio M, Cargnoni A, Comini L, Pasini E, Gaia G, et al. Heat shock protein changes in hibernation: a similarity with heart failure? J Mol Cell Cardiol. 1996;28(12):2383-95.]
|
To examine the influence of free radicals on HSP70 expression in the heart |
Free radicals ↑HSP70 |
| Kukreja et al.[1919 Kukreja RC, Qian YZ, Okubo S, Flaherty EE. Role of protein kinase C and 72 kDa heat shock protein in ischemic tolerance following heat stress in the rat heart. Mol Cell Biochem. 1999;195(1-2):123-31.]
|
To verify the hypothesis that inhibition of protein kinase C would block the cardioprotection mediated by heat stress |
Heat stress ↑HSP70 and ↓infarct size / PKC inhibitor
↓HSP70 |
| Kwon et al.[1313 Kwon JH, Kim JB, Lee KH, Kang SM, Chung N, Jang Y, et al. Protective effect of heat shock protein 27 using protein transduction domain-mediated delivery on ischemia/reperfusion heart injury. Biochem Biophys Res Commun. 2007;363(2):399-404.]
|
To evaluate the efficacy of an intracellular delivery system in the expression of HSP27 and in cardiac protection |
Intracellular delivery system ↑HSP27 / ↑HSP27
↓apoptosis and ↓size of the infarcted area / ↑HSP27 promotes heart protection against ischemia |
| Latif et al.[6161 Latif N, Yacoub MH, Dunn MJ. Association of pretransplant anti-heart antibodies against human heat shock protein 60 with clinical course following cardiac transplantation. Transplant Proc. 1997;29(1-2):1039-40.]
|
To quantify levels of circulating anti-HSP60 antibodies in the cardiac transplant patient |
↑HSP60 antibodies in sera appear to have a worse prognosis |
| Li et al.[3434 Li Q, Shi M, Li B. Anandamide enhances expression of heat shock protein 72 to protect against ischemia-reperfusion injury in rat heart. J Physiol Sci. 2013;63(1):47-53.]
|
To test the effect of anandamide in HSP72 expression and cardioprotection |
Anadamide ↑HSP70 and protect the heart against ischemia/reperfusion injury |
| Li et al.[1717 Li Z, Song Y, Xing R, Yu H, Zhang Y, Li Z, et al. Heat shock protein 70 acts as a potential biomarker for early diagnosis of heart failure. PLoS One. 2013;8(7):e67964.]
|
To characterize the expression of circulating HSP in HF |
↑HSP27 and ↑HSP70 in animals and ↑HSP70 in humans with HF / ↑HSP70 with progression of HF |
| Marunouchi et al.[77 Marunouchi T, Murata M, Takagi N, Tanonaka K. Possible involvement of phosphorylated heat-shock factor-1 in changes in heat shock protein 72 induction in the failing rat heart following myocardial infarction. Biol Pharm Bull. 2013;36(8):1332-40.]
|
To analyze the HSF-1 and HSP70 kinetics after HF |
↑HSP72 and ↑HSF1 in the 2nd week after HF /
↓HSP72 and ↓HSF1 after heat exposure with disease progression |
| McGinley et al.[3535 McGinley LM, McMahon J, Stocca A, Duffy A, Flynn A, O'Toole D, et al. Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression. Hum Gene Ther. 2013;24(10):840-51.]
|
To investigate the effect of exogenous HSP27 on mesenchymal stem cell therapy in the heart |
↑HSP27 ↑the survival of cell therapy in vitro and in vivo / ↑HSP27 ↓apoptosis and ↑cardiac function |
| Meldrum et al.[2121 Meldrum DR, Meng X, Shames BD, Pomerantz B, Donnahoo KK, Banerjee A, et al. Liposomal delivery of heat-shock protein 72 into the heart prevents endotoxin-induced myocardial contractile dysfunction. Surgery. 1999;126(2):135-41.]
|
To determine the effect of liposomal delivery of HSP70 and the role in cardioprotection |
Intracoronary perfusion of the liposomal protein
↑HSP70 in the myocardium / ↑HSP70 prevents LPS-induced dysfunction |
| Moalic et al.[3838 Moalic JM, Bauters C, Himbert D, Bercovici J, Mouas C, Guicheney P, et al. Phenylephrine, vasopressin and angiotensin II as determinants of proto-oncogene and heat-shock protein gene expression in adult rat heart and aorta. J Hypertens. 1989;7(3):195-201.]
|
To verify the involvement of circulating hormones in HSP70 expression |
Heat stress ↑HSP70 / Phenylephrine and vasopressin
↑HSP70, but angiotensin II did not |
| Niizeki et al.[6969 Niizeki T, Takeishi Y, Watanabe T, Nitobe J, Miyashita T, Miyamoto T, et al. Relation of serum heat shock protein 60 level to severity and prognosis in chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 2008;102(5):606-10.]
|
To examine whether HSP 60 is correlated with the severity of CHF |
↑HSP60 in patients with CHF to the control group /
↑HSP60 was associated with functional classification of CHF and risk of adverse events |
| Nomura et al.[2222 Nomura F, Aoki M, Forbess JM, Mayer JE Jr. Myocardial self-preservative effect of heat shock protein 70 on an immature lamb heart. Ann Thorac Surg. 1999;68(5):1736-41.]
|
To investigate the role of HSP70 in the recovery of hypothermic cardioplegic ischemia |
↑HSP70 expression in 15 min after heat stress (43°) and persisted up to 24h / ↑HSP70 improved the recovery of systolic and coronary endothelial function |
| Okubo et al.[1212 Okubo S, Wildner O, Shah MR, Chelliah JC, Hess ML, Kukreja RC. Gene transfer of heat-shock protein 70 reduces infarct size in vivo after ischemia/reperfusion in the rabbit heart. Circulation. 2001;103(6):877-81.]
|
To observe the effect of the overexpression of HSP70 in myocardial protection |
↑HSP70 ↓myocardial infarct size / ↑HSP70 ↓the severity of ischemic injury |
| Ooie et al.[2424 Ooie T, Takahashi N, Saikawa T, Nawata T, Arikawa M, Yamanaka K, et al. Single oral dose of geranylgeranylacetone induces heat-shock protein 72 and renders protection against ischemia/reperfusion injury in rat heart. Circulation. 2001;104(15):1837-43.]
|
To examine the role of geranylgeranyl acetone (GGA) in HSP expression in cardioprotection |
Treatment ↑HSP70 dose-dependent manner with peak expression at 24 hours after administration / ↑HSP72 provides cardioprotection by ischemia/reperfusion and ↑post-ischemic recovery |
| Osaki et al.[4444 Osaki J, Haneda T, Kashiwagi Y, Oi S, Fukuzawa J, Sakai H, et al. Pressure-induced expression of heat shock protein 70 mRNA in adult rat heart is coupled both to protein kinase A-dependent and protein kinase C-dependent systems. J Hypertens. 1998;16(8):1193-200.]
|
To examine the involvement of protein kinase A and protein kinase C in pressure-induced HSP70 expression |
Elevation of aortic pressure ↑HSP70 / ↑HSP70 are regulated both by PKA and PKC-dependent systems |
| Qian et al.[2020 Qian YZ, Bernardo NL, Nayeem MA, Chelliah J, Kukreja RC. Induction of 72-kDa heat shock protein does not produce second window of ischemic preconditioning in rat heart. Am J Physiol. 1999;276(1 Pt 2):H224-34.]
|
To investigate the ischemic preconditioning cardioprotection and to correlate with HSP70 expression |
Heat stress and preconditioning ↑HPS70 / heat stress
↓infarct size |
| Qiu et al.[7373 Qiu H, Lizano P, Laure L, Sui X, Rashed E, Park JY, et al. H11 kinase/heat shock protein 22 deletion impairs both nuclear and mitochondrial functions of STAT3 and accelerates the transition into heart failure on cardiac overload. Circulation. 2011;124(4):406-15.]
|
To determine the function of HSP22 in cardiac overload pressure |
HSP22 deletion accelerates transition to HF in the context of cardiac overload pressure |
| Rahsepar et al.[7272 Rahsepar AA, Mirzaee A, Moodi F, Moohebati M, Tavallaie S, Eshraghi A, et al. Anti-heat shock protein 27 titers and oxidative stress levels are elevated in patients with valvular heart disease. Angiology. 2012;63(8):609-16.]
|
To analyze the levels of HSP27 in patients with valvular heart disease |
↑HSP27 in patients with valvular heart disease /
↑HSP27 may be useful as a biomarker in the assessment of HF |
| Raju et al.[4545 Raju VS, Imai N, Liang CS. Chamber-specific regulation of heme oxygenase-1 (heat shock protein 32) in right-sided congestive heart failure. J Mol Cell Cardiol. 1999;31(8):1581-9.]
|
To investigate the regulation of HSP32 in the right-sided congestive heart failure model |
Congestive heart failure ↑HSP32, but ↔HSP70 |
| Rinaldi et al.[88 Rinaldi B, Corbi G, Boccuti S, Filippelli W, Rengo G, Leosco D, et al. Exercise training affects age-induced changes in SOD and heat shock protein expression in rat heart. Exp Gerontol. 2006;41(8):764-70.]
|
To observe the effects of age and exercise on the antioxidant system and expression of HSP27 and HSP70 |
Physical exercise ↑HSP27 and ↑HSP70 / ↑HSP27 and
↑HSP70 ↓the deleterious effect of age on the antioxidant system of the heart |
| Rothenbacher et al.[6363 Rothenbacher D, Hoffmeister A, Bode G, Miller M, Koenig W, Brenner H. Helicobacter pylori heat shock protein 60 and risk of coronary heart disease: a case control study with focus on markers of systemic inflammation and lipids. Atherosclerosis. 2001;156(1):193-9.]
|
To investigate whether HSP60 is associated with heart disease |
↑HSP60 does not seem to be an independent risk factor for coronary artery disease |
| Satoh et al.[6666 Satoh M, Shimoda Y, Akatsu T, Ishikawa Y, Minami Y, Nakamura M. Elevated circulating levels of heat shock protein 70 are related to systemic inflammatory reaction through monocyte Toll signal in patients with heart failure after acute myocardial infarction. Eur J Heart Fail. 2006;8(8):810-5.]
|
To determine the relationship between blood HSP70 and TLR4 after myocardial infarction |
↑HSP70 in patients than controls / ↑HSP70 and
↑cytokines mediated TLR4 receptor |
| Schmitt et al.[4848 Schmitt JP, Schunkert H, Birnbaum DE, Aebert H. Kinetics of heat shock protein 70 synthesis in the human heart after cold cardioplegic arrest. Eur J Cardiothorac Surg. 2002;22(3):415-20.]
|
To investigate the synthesis of HSP70 in the human heart in vivo after CABG |
↑HSP70 occurred after at least 2 hours of stress induction by CABG |
| Shinohara et al.[2626 Shinohara T, Takahashi N, Ooie T, Ichinose M, Hara M, Yonemochi H, et al. Estrogen inhibits hyperthermia-induced expression of heat-shock protein 72 and cardioprotection against ischemia/reperfusion injury in female rat heart. J Mol Cell Cardiol. 2004;37(5):1053-61.]
|
To observe the effect of estrogen on the expression of HSP72 after ischemic damage |
Estrogen ↓HSP72 induced by hyperthermia /↑HSP72 promotes ischemic protection |
| Staib et al.[66 Staib JL, Quindry JC, French JP, Criswell DS, Powers SK. Increased temperature, not cardiac load, activates heat shock transcription factor 1 and heat shock protein 72 expression in the heart. Am J Physiol Regul Integr Comp Physiol. 2007;292(1):R432-9.]
|
To investigate the effect of heat stress and mechanical overload on the HSP70 expression |
Hyperthermia, regardless of workload, resulted in significant ↑HSP70 in the heart |
| Tanonaka et al.[55 Tanonaka K, Furuhama KI, Yoshida H, Kakuta K, Miyamoto Y, Toga W, et al. Protective effect of heat shock protein 72 on contractile function of perfused failing heart. Am J Physiol Heart Circ Physiol. 2001;281(1):H215-22.]
|
To evaluate the HSP72 production level during CHF and its relation to cardiac protection |
Hyperthermia ↑HSP72 in the 2nd week, but not in the 8th week / ↑HSP72 was inversely correlated with worsening of the cardiac parameters / Advanced HF
↓HSP72 |
| Tanonaka et al.[4343 Tanonaka K, Toga W, Yoshida H, Takeo S. Myocardial heat shock protein changes in the failing heart following coronary artery ligation. Heart Lung Circ. 2003;12(1):60-5.]
|
To verify the expression of HSP during the development of HF |
↑HSP27 and ↑HSP70 in the 1st week, but not in the 8th week / There was ↑HSP60 only in the 8th week |
| Tanonaka et al.[3939 Tanonaka K, Toga W, Takahashi M, Yoshida H, Oikawa R, Takeo S. Induction of heat shock protein 72 in the failing heart is attenuated after an exposure to heat shock. Mol Cell Biochem. 2004;259(1-2):211-5.]
|
To examine the HSP72 expression in HF after acute myocardial infarction |
The development of HF ↓HSP70 by hyperthermia |
| Ugurlucan et al.[1010 Ugurlucan M, Erer D, Karatepe O, Ziyade S, Haholu A, Gungor Ugurlucan F, et al. Glutamine enhances the heat shock protein 70 expression as a cardioprotective mechanism in left heart tissues in the presence of diabetes mellitus. Expert Opin Ther Targets. 2010;14(11):1143-56.]
|
To investigate the effect of diabetes mellitus and glutamine administration on HSP70 expression in the heart |
Diabetes ↑HSP70 in the myocardium / Parenteral administration of glutamine ↑HSP70 |
| Veres et al.[6464 Veres A, Szamosi T, Ablonczy M, Szamosi Jr T, Singh M , Karádi I, et al. Complement activating antibodies against the human 60 kDa heat shock protein as a new independent family risk factor of coronary heart disease. Eur J Clin Invest. 2002;32(6):405-10.]
|
To explore the relationship between familial risk for heart disease and HSP60 |
↑HSP60 in the group with high familial risk / Children with ↑HSP60 showed higher values of odds ratio for heart disease / ↑HSP60 can be considered a relative risk factor for heart disease |
| Vittorini et al.[1414 Vittorini S, Storti S, Andreani G, Giusti L, Murzi B, Furfori P, et al. Heat shock protein 70-1 gene expression in pediatric heart surgery using blood cardioplegia. Clin Chem Lab Med. 2007;45(2):244-8.]
|
To assess the HSP70 gene expression during blood cardioplegic arrest in children |
Blood cardioplegia ↑HSP70 and protection of the ischemia/reperfusion injury |
| Wang et al.[4646 Wang Y, Chen L, Hagiwara N, Knowlton AA. Regulation of heat shock protein 60 and 72 expression in the failing heart. J Mol Cell Cardiol. 2010;48(2):360-6.]
|
To investigate the regulation and transcription of HSP60 and HSP72 in HF |
There were ↑HSP60 and hNF kB in HF / ↑HSP60 may be mediated by hNFkB / ↔HSP70 because ↔HSF1 in HF |
| Wei et al.[1515 Wei YJ, Huang YX, Shen Y, Cui CJ, Zhang XL, Zhang H, et al. Proteomic analysis reveals significant elevation of heat shock protein 70 in patients with chronic heart failure due to arrhythmogenic right ventricular cardiomyopathy. Mol Cell Biochem. 2009;332(1-2):103-11.]
|
To observe protein changes in hearts with HF and to identify potential biomarkers of this condition |
↑HSP70 is the common feature of HF / ↑HSP70 may be used as a biomarker for the presence of HF and may hold diagnostic/prognostic potential in clinical practice |
| Wu et al.[3636 Wu W, Lu Z, Li Y, Chen Z, Jiang H, Li Y. Decreased Cardiac Expression of Heat Shock Protein 27 is Associated with Atrial Fibrillation in Patients with Rheumatic Heart Disease. Acta Cardiol Sin. 2015;31(1):1-7.]
|
To compare HSP expression in patients with and without atrial fibrillation |
↓HSP27 in patients with atrial fibrillation |
| Xi et al.[3737 Xi L, Chelliah J, Nayeem MA, Levasseur JE, Hess ML, Kukreja RC. Whole body heat shock fails to protect mouse heart against ischemia/reperfusion injury: role of 72 kDa heat shock protein and antioxidant enzymes. J Mol Cell Cardiol. 1998;30(11):2213-27.]
|
To investigue whether the whole-body heat stress induces HSP70 expression and offers cardioprotection |
Whole-body heat stress ↑HSP70 / No differences in HSP70 or control groups in infarct size after ischemia/reperfusion |
| Yamanaka et al.[99 Yamanaka K, Takahashi N, Ooie T, Kaneda K, Yoshimatsu H, Saikawa T. Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart. J Mol Cell Cardiol. 2003;35(7):785-94.]
|
To investigate the effect of treatment with geranylgeranyl acetone (GGA) in the expression of HSP72 |
Treatment with GGA ↑HSP72 and ↑HSF-1 / ↑the recovery after ischemia/reperfusion / ↑HSP72 promoted cardioprotection |
| Yamashita et al.[1818 Yamashita N, Hoshida S, Nishida M, Igarashi J, Aoki K, Hori M, et al. Time course of tolerance to ischemia-reperfusion injury and induction of heat shock protein 72 by heat stress in the rat heart. J Mol Cell Cardiol. 1997;29(7):1815-21.]
|
To compare the time course of tolerance to myocardial injury with the time course of HSP70 induction |
↓infarct size in 48 and 72 hours after heat stress / ↑HSP70 content correlates with time course of cardioprotection |
| Yan et al.[5555 Yan J, Bao E, Yu J. Heat shock protein 60 expression in heart, liver and kidney of broilers exposed to high temperature. Res Vet Sci. 2009;86(3):533-8.]
|
To investigate the expression of HSP60 in the heart, liver, and kidney of stressed broilers |
↑HSP60 is specific and can be related to tissue damage in response to thermal stress / In the heart ↑HSP60 peaked at 5h after stress |
| Yu et al.[5454 Yu H, Bao ED, Zhao RQ, Lv QX. Effect of transportation stress on heat shock protein 70 concentration and mRNA expression in heart and kidney tissues and serum enzyme activities and hormone concentrations of pigs. Am J Vet Res. 2007;68(11):1145-50.]
|
To determine the HSP70 expression in cardiac and renal tissues of transport-stressed pigs |
Transport stress ↑HSP70 in cardiac and renal tissues |
| Yu et al.[5050 Yu H, Yokoyama M, Asano G. Time course of expression and localization of heat shock protein 72 in the ischemic and reperfused rat heart. Jpn Circ J. 1999;63(4):278-87.]
|
To examine the expression of HSP70 after several periods of ischemia/reperfusion |
Permanent ischemia and ischemia/reperfusion ↑HSP70 / ↑HSP70 from 30 min to 24h after ischemia/reperfusion |
| Zhang et al.[7070 Zhang X, He M, Cheng L, Chen Y, Zhou L, Zeng H, et al. Elevated heat shock protein 60 levels are associated with higher risk of coronary heart disease in Chinese. Circulation. 2008;118(25):2687-93.]
|
To observe the correlation of HSP60 and CHD |
↑HSP60 is related to the risk of CHD |
| Zhang et al.[7171 Zhang X, He MA, Cheng L, Zhou L, Zeng H, Wang J, et al. Joint effects of antibody to heat shock protein 60, hypertension, and diabetes on risk of coronary heart disease in Chinese. Clin Chem. 2008;54(6):1046-52.]
|
To determine whether HSP60, hypertension and diabetes have joint effects on CHD risk |
↑HSP60 in the group with CHD than controls / ↑HSP60 is positively correlated with the risk and severity of CHD |
| Zhao et al.[3232 Zhao B, Sun G, Feng G, Duan W, Zhu X, Chen S, et al. Carboxy terminus of heat shock protein (HSP) 70-interacting protein (CHIP) inhibits HSP70 in the heart. J Physiol Biochem. 2012;68(4):485-91.]
|
To examine the effects of probiotics-derived protein on heart injury |
Probiotics-derived protein ↑HSP70 in heart cells and
↓ damage of ischemia/reperfusion |
| Zhong et al.[1111 Zhong N, Zhang Y, Fang QZ, Zhou ZN. Intermittent hypoxia exposure-induced heat-shock protein 70 expression increases resistance of rat heart to ischemic injury. Acta Pharmacol Sin. 200;21(5):467-72.]
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To quantify the HSP70 levels hypoxia-induced and its relation to cardioprotection |
Hypoxia ↑HSP70 and it provides protection against ischemia/reperfusion / ↑HSP70 can stay up to two weeks after hypoxia |
| Zhu and Wang[2929 Zhu YH, Wang X. Overexpression of heat-shock protein 20 in rat heart myogenic cells confers protection against simulated ischemia/reperfusion injury. Acta Pharmacol Sin. 2005;26(9):1076-80.]
|
To explore whether overexpression of HSP20 in cardiomyocytes protects against injury |
↑HSP20 ↓the necrotic and ↓apoptotic cardiomyocytes |
