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Hepatectomy for metastasis from colorectal and non-colorectal origin: comparative analysis in 30 resectable cases

BACKGROUND: Hepatectomy has presented the best curative therapeutic choice for hepatic metastatic colorectal cancer. More recently, hepatic resection has been performed for hepatic metastases from non-colorectal origin too. AIM: To compare both early and long-term surgical outcomes on 20 patients' series of colorectal with 10 patients' series of non-colorectal hepatic metastases realized by General Surgery Service (Discipline of Tract Digestive Surgery) of ABC Medical School (Santo André - Brazil). METHODS: Complete follow-up data were available on 30 patients who underwent hepatectomy for metastatic methacronic cancer between January 2001 and September 2007. Twenty patients presented colorectal liver metastases (Group 1) were compared with ten patients presented non-colorectal metastases (Group 2). RESULTS: There were twenty major hepatic resections and ten minor hepatic resections. Overall morbidity rates were similar between Groups 1 and 2 (p = ns). Overall mortality in Group 1 was higher than Group 2 (5 % X 0 %), nevertheless there was no statistical significance (p=ns). Both 3 and 5-year overall survival rates were comparable between groups (p=ns). Both number of lesions and nodal disease were considered dismal prognostic factors. CONCLUSION: In this sample, hepatic resection for liver metastasis from non-colorectal and nonneuroendocrine origin presents similar results to colorectal metastasis. Multiple metastases and positive node were adverse prognostic factors.

Colorrectal neoplasm; Hepatectomy; Neoplasm metastasis; Liver neoplasm; Liver neoplasm; Survival rate


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