Serum chromogranin A levels are associated with the SYNTAX score in coronary artery disease

Çelikkol, Aliye; Demirkıran, Aykut; Aydın, Cihan; Akyüz, Aydın; Kaplangöray, Mustafa; Yılmaz, Ahsen; Efe, Muhammed Mucip; Güzel, Savaş

doi:10.1590/1806-9282.20221254

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Original Article • Rev. Assoc. Med. Bras. 69 (4) • 2023 • https://doi.org/10.1590/1806-9282.20221254 copy

Serum chromogranin A levels are associated with the SYNTAX score in coronary artery disease

Authorship SCIMAGO INSTITUTIONS RANKINGS

SUMMARY

OBJECTIVE:

In this article, we investigated the association of chromogranin A with coronary artery disease.

METHODS:

Biochemical parameters and chromogranin A levels obtained from peripheral blood samples during coronary angiography were analyzed in 90 patients. Patients were classified into two groups, namely, SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1 (n=45) and SYNergy between PCI with TAXUS and Cardiac Surgery score=0 (n=45). This is a cross-sectional, prospective study.

RESULTS:

Serum chromogranin A levels were significantly higher in the group with SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1 compared to the group with SYNergy between PCI with TAXUS and Cardiac Surgery score=0 (1381.5±418.9 ng/mL and 1121.2±290.7 ng/mL, respectively; p=0.002). Serum chromogranin A levels were correlated with SYNergy between PCI with TAXUS and Cardiac Surgery score (r=0.556, p<0.04). ROC analysis showed that the area under the curve for serum chromogranin A levels was 0.687 (p=0.007), and the best cutoff value of 1,131 ng/mL had a sensitivity of 67% and a specificity of 65% for the prediction of coronary artery disease.

CONCLUSION:

Serum chromogranin A levels were increased in coronary artery disease patients with SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1. Increasing serum chromogranin A levels are proportional to the SYNergy between PCI with TAXUS and Cardiac Surgery score.

KEYWORDS:
Chromogranin A; Coronary artery disease; Hypertension

Variable	SYNTAX score=0 n=45	SYNTAX score ≥ 1 n=45	p-value
Plasma CgA level, ng/mL	1121.2±290.7	1381.5±418.9	0.002
Age, years	51±7	58±8	0.047
Male, n (%)	23 (51)	29 (64)	0.002
Systolic blood pressure, mmHg	124±12	134±15	0.042
Diastolic blood pressure, mmHg	75±8	76±9	0.876
Type II diabetes mellitus, n (%)	16 (35)	22 (48)	0.001
Smoking, n (%)	8 (17)	15 (33)	<0.001
Hypertension, n (%)	25 (55)	32 (71)	<0.001
Hyperlipidemia, n (%)	18 (40)	19 (42)	0.828
Glucose, mg/dL	106±16	141±66	0.012
Creatinine, mg/dL	0.8±0.1	0.8±0.2	0.354
Urea, mg/dL	26±6	29±9	0.079
Total cholesterol, mg/dL	191±32	193±36	0.850
HDL cholesterol, mg/dL	51±11	36±15	0.034
LDL cholesterol, mg/dL	117±27	114±39	0.727
Triglycerides, mg/dL	162±75	194±90	0.284
CRP, mg/dL	1.6±1	3.2±1	0.101
Leukocytes, 10⁶/mm³	6.7±2.6	7.3±1.6	0.193
Neutrophils, 10⁶/mm³	3.7±1.2	4.6±1.4	0.009
Lymphocytes, 10⁶/mm³	2.0±0.5	2.1±0.6	0.403
Monocytes,10⁶/mm³	0.4±0.1	0.5±0.1	0.602
Hemoglobin, g/dL	14.2±1.6	13.7±1.5	0.246
Platelets, 10³/mm³	214±62	253±60	0.013

Variable		OR (95%CI)	p-value
Model 1
	Age, years	1.9 (1.7–2.9)	<0.001
	Gender, male	2.0 (1.5–2.7)	<0.001
	Diagnosis of diabetes	1.3 (0.9–1.9)	0.082
	Hyperlipidemia	1.4 (1.1–2.0)	0.071
	Smoking	3.2 (2.3–6.5)	<0.001
	hs-C-reactive protein	1.7 (1.2–2.5)	0.003
Model 2
	Age, years	2.0 (1.8–3.1)	<0.001
	Gender, male	2.0 (1.4–2.7)	<0.001
	Diagnosis of diabetes	1.1 (0.7–1.7)	0.212
	Hyperlipidemia	1.2 (1.0–1.8)	0.121
	Smoking	2.2 (1.3–4.5)	<0.001
	hs-C-reactive protein	1.6 (1.1–2.3)	0.006
	Plasma CgA level, ng/mL	1.6 (1.1–1.9)	0.036

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[1] *Corresponding author: drcihanaydin@hotmail.com