SUMMARY
Objective:
To review and discuss the literature on hematopoietic stem cell transplantation (HSCT) with haploidentical donors in Brazil.
Method:
Literature review.
Results:
The haploidentical hematopoietic stem cell transplantations have become a safe option in hematology since the 80s, with the possibility of ex-vivo T-cell depletion. However, its broad use worldwide occurred with the advent of haploidentical nonmyeloablative transplants using in vivo T-cell depletion with the administration of post-transplant cyclophosphamide. The results were encouraging, despite the increased risk of infection and post-transplantation recurrence. Recent publications on acute myeloid leukemia, myelodysplastic syndrome and Hodgkin’s lymphoma have shown similar results among haploidentical, unrelated and related full-match transplants. Obviously, these findings of retrospective studies should be confirmed by clinical trials.
Conclusions:
Transplantation with haploidentical donor has shown to be feasible in Brazil and the first publications and results are showing encouraging results.
Keywords
Bone Marrow Transplantation; Stem cells; Transplants
