Chemical investigation of Croton gratissimus led to the isolation of fourteen compounds, and their structures were identified to be caryophyllene oxide (1), 1β-methoxycaryolan-9β-ol (2), kaur-16-en-19-oic acid (3), cis-ozic acid (4), spathulenol (5), lupeol (6), 7δ-methoxyopposit-4(15)-en-1β-ol (7), germacra-4(15),5,10(14)-trien-1β-ol (8), β-sitosterol (9), ent-kaur-16-en-18-ol (10), 15-methoxy-neo-clerodan-3,13-dien-16,15-olide-18-oic acid (11), 6α-methoxyeudesm-4(15)-en-1β-ol (12), sucrose (13) and N-methyl-trans-4-hydroxy-L-proline (14) on the basis of 1D and 2D-NMR spectra. This is the first report on the occurrence of compounds (2), (4), (7), (9-12, 14) in the genus Croton.
Keywords:
Euphorbiaceae; Croton gratissimus; diterpenes; sesquiterpenes
