Clostridium perfringens α and β recombinant toxoids in equine immunization

Toxóides recombinantes α e β de Clostridium perfringens na imunização de equinos

ABSTRACT:

Clostridium perfringens is considered one of the main causative agents of superacute enterocolitis, usually fatal in the equine species, due to the action of the β toxin, and is responsible for causing severe myonecrosis, by the action of the α toxin. The great importance of this agent in the equine economy is due to high mortality and lack of vaccines, which are the main form of prevention, which guarantee the immunization of this animal species. The aim of this study was to evaluate three different concentrations (100, 200 and 400μg) of C. perfringens α and β recombinant toxoids in equine immunization and to compare with a group vaccinated with a commercial toxoid. The commercial vaccine was not able to stimulate an immune response and the recombinant vaccine was able to induce satisfactory humoral immune response in vaccinated horses, proving to be an alternative prophylactic for C. perfringens infection.

INDEX TERMS:
Clostridium perfringens; alpha toxin; beta toxin; recombinant toxoids; equine; immunization; vaccination; myonecrosis; enterocolitis; horses