Efeitos da mielografia lombar na pressão subaracnoidea e nos parâmetros cardiorrespiratórios em ovelhas saudáveis

O objetivo foi avaliar os efeitos da mielografia lombar na pressão subaracnóidea, parâmetros cardiorrespiratórios e índice pressão-volume em ovinos. Oito ovelhas foram avaliadas. Os animais foram submetidos à punção da cisterna magna para monitoramento da pressão subaracnoidea (SaP). A mielografia lombar foi realizada com a aplicação de Iohexol (0,4mL/kg). Os momentos estudados foram: imediatamente após a estabilização anestésica (M0), durante a punção lombar (M1), dois, quatro e seis minutos após a aplicação do contraste (M2, M3 e M4, respectivamente), para avaliar as seguintes variáveis: T^oC, PAS, PAD, MAP, InspISO, FeISO, Sap e CPP. A pressão arterial aumentou inicialmente, depois diminuiu, retornando aos valores iniciais, padrão também observado para o InspISo e o FeISo. O SaP subiu inicialmente, posteriormente, permanecendo estável. A mielografia lombar, apesar de influenciar a pressão subaracnoidea, pode ser considerada segura em ovinos.

TERMOS DE INDEXAÇÃO:
Mielografia; lombar; pressão subaracnóidea; cardiorrespiração; ovelhas neurorradiologia; pressão intracraniana; ovinos; índice volume-pressão

Autoria

Bruno W. Minto

Departamento de Clínica Veterinária, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Via de Acesso Prof. Paulo Donato Castellane, Vila Industrial, Jaboticabal, SP 14884-900, Brazil.Universidade Estadual PaulistaBrazilJaboticabal, SP, BrazilDepartamento de Clínica Veterinária, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Via de Acesso Prof. Paulo Donato Castellane, Vila Industrial, Jaboticabal, SP 14884-900, Brazil.

Luciane R. Mesquita ^**Corresponding author: lrmesquita@yahoo.com.br

Departamento de Cirurgia e Anestesiologia Veterinária, Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Rua Prof. Dr. Valter Corrêa s/n, Botucatu, SP 18618-681, Brazil.Universidade Estadual PaulistaBrazilBotucatu, SP, BrazilDepartamento de Cirurgia e Anestesiologia Veterinária, Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Rua Prof. Dr. Valter Corrêa s/n, Botucatu, SP 18618-681, Brazil.

http://orcid.org/0000-0003-3853-7084

João A.L. Souza

Gabriela M. Bueno

Luís G. Faria

Fernando Y.K. Kawamoto

Diego Yamada

Luis C. Marques

*Corresponding author: lrmesquita@yahoo.com.br

Conflict of interest statement.- The authors have no competing interests.

SCIMAGO INSTITUTIONS RANKINGS

Figuras | Tabelas | Fórmulas

Figuras (2)
Tabelas (5)
Fórmulas (1)

Thumbnail

Fig.1.
Graphical representation of the polynomial trend line of the variables HR = heart rate (blue lines and traces), MAP = mean blood pressure (red lines and points), SaP = subarachnoid pressure (yellow lines and cross) and CPP = cerebral perfusion pressure (purple lines and X) of the experimental model of ovine submitted to lumbar myelography and measurement of subarachnoid pressure.

Thumbnail

Fig.2.
Pressure-volume indexes (PVI) graphically plotted against body weight. The trend line obtained by linear regression, showing the resulting straight-line equation, as well as the Pearson and p.

Thumbnail

Table 1.
Mean and standard deviation and Tukey’s test of body temperature (T^oC), respiratory rate (RR), heart rate (HR), systolic blood pressure (PAS), diastolic blood pressure (PAD), mean blood pressure (PAM), expired fraction of carbon dioxide (EtCO₂), oxygen saturation (SpO₂), inhaled Isoflurane concentrations (InspISO), exhaled Isoflurane concentrations (FeISO), subarachnoid pressure (SaP) and cerebral perfusion pressure (CPP) of the experimental model of ovine submitted to lumbar myelography and subarachnoid pressure

Thumbnail

Table 2.
Pearson correlation among the variables body temperature (T^oC), respiratory rate (RR), heart rate (HR), diastolic blood pressure (PAD), mean blood pressure (PAM), expired fraction of carbon dioxide (EtCO₂), oxygen saturation (SpO₂), inhaled Isoflurane concentrations (InspISO), exhaled Isoflurane concentrations (FeISO), subarachnoid pressure (SaP) and cerebral perfusion pressure (CPP), exposing the r value of the experimental model of ovine submitted to lumbar myelography and pressure gauging subarachnoid

Thumbnail

Table 3.
Mean and standard deviation of the variables body weight, measured length of nuchal ridge to iliac tuberosity, infused contrast volume, pressure volume-index (PVI), subarachnoid pressure (Sap0) and maximum subarachnoid pressure (SaPmax), obtained from the experimental model of ovine submitted to lumbar myelography and gauging subarachnoid pressure

Thumbnail

Table 4.
Pearson correlation between the variables: body weight, length, contrast volume and pressure volume-index (PVI) exposing the r value of the experimental model of ovine submitted to lumbar myelography and subarachnoid pressure measurement

Thumbnail

Table 5.
Relation of pressure volume-index (PVI) values, body weight, contrast volume and dose required to increase maximal subarachnoid pressure (SaPmax) at 40, 50 and 60mmHg as a theoretical limit of pressure of the experimental model of ovine submitted to lumbar myelography and check of subarachnoid pressure

Thumbnail

Fig.1. Graphical representation of the polynomial trend line of the variables HR = heart rate (blue lines and traces), MAP = mean blood pressure (red lines and points), SaP = subarachnoid pressure (yellow lines and cross) and CPP = cerebral perfusion pressure (purple lines and X) of the experimental model of ovine submitted to lumbar myelography and measurement of subarachnoid pressure.

Fig.2. Pressure-volume indexes (PVI) graphically plotted against body weight. The trend line obtained by linear regression, showing the resulting straight-line equation, as well as the Pearson and p.

Table 1. Mean and standard deviation and Tukey’s test of body temperature (T^oC), respiratory rate (RR), heart rate (HR), systolic blood pressure (PAS), diastolic blood pressure (PAD), mean blood pressure (PAM), expired fraction of carbon dioxide (EtCO₂), oxygen saturation (SpO₂), inhaled Isoflurane concentrations (InspISO), exhaled Isoflurane concentrations (FeISO), subarachnoid pressure (SaP) and cerebral perfusion pressure (CPP) of the experimental model of ovine submitted to lumbar myelography and subarachnoid pressure

Moment	T^o (^oC)	RR (MPM)	HR (BPM)	PAS (mmHg)	PAD (mmHg)	PAM (mmHg)	EtCO₂ (mmHg)	SpO₂ (%)	InspISO (%)	FeISO (%)	SaP (mmHg)	CPP (mmHg)
M0	37.58	9.25	107.38	89.00	62.38	76.13	41.25	97.50	1.56	1.08	11.13	65.00
M0	(±1.05)A	(±2.19)A	(±14.62)A	(± 11.86)A	(±12.76)A	(±11.75)A	(±2.76)A	(±1.06)A	(±0.09)A	(±0.1)A	(±4.15)A	(±12.11)AB
M1	37.01	10.00	118.87	121.00	92.1	105.25	42.63	97.38	1.71	1.31	101.88	3.38
M1	(±1.05)B	(±1.85)A	(±26.40)A	(±26.79)C	(±24.38)C	(±24.81)B	(±3.46)A	(±0.74)A	(±0.14)B	(±0.15)B	(±22.53)C	(±13.85)C
M2	36.94	9.88	112.38	107.38	82.75	90.25	42.75	97.38	1.71	1.28	43.13	47.13
M2	(±0.93)BC	(±2.16)A	(±23.27)A	(±21.77)BC	(±21.76)BC	(±20.35)A	(±4.13)A	(±0.91)A	(±0.12)B	(±0.15)B	(±9.94)B	(±22.06)B
M3	36.85	9.88	108.00	100.88	75.38	85.88	41.13	97.00	1.76	1.31	19.13	66.75
M3	(±0.96)BC	(±1.95)A	(±21.98)A	(±18.90)AB	(±19.28)AB	(±21.07)A	(±4.32)A	(±0.92)A	(±0.14)B	(±0.14)B	(±3.44)A	(±23.34)A
M4	36.83	9.88	108.25	99.38	74.50	85.75	42.13	97.38	1.76	1.31	15.25	70.50
M4	(±0.97)C	(±1.95)A	(±23.37)A	(±22.26)AB	(±19.53)AB	(±20.21)A	(±3.83)A	(±0.74)A	(±0.15)B	(±0.17)B	(±5.06)A	(±22.03)A

A,B,C = different letters in the same column indicate statistical difference at 5% by the Tukey test.

Table 2. Pearson correlation among the variables body temperature (T^oC), respiratory rate (RR), heart rate (HR), diastolic blood pressure (PAD), mean blood pressure (PAM), expired fraction of carbon dioxide (EtCO₂), oxygen saturation (SpO₂), inhaled Isoflurane concentrations (InspISO), exhaled Isoflurane concentrations (FeISO), subarachnoid pressure (SaP) and cerebral perfusion pressure (CPP), exposing the r value of the experimental model of ovine submitted to lumbar myelography and pressure gauging subarachnoid

	T^o	RR	HR	PAS	PAD	PAM	EtCO₂	SpO₂	InspISO	FeISO	SaP	CPP
T^o	1
RR	-0.327*£	1
HR	-0.286	0.538*§	1
PAS	0.133	-0.618*§	-0.032	1
PAD	0.209	-0.629*§	-0.091	0.932*∂	1
PAM	0.183	-0.683*§	-0.134	0.967*∂	0.942*∂	1
EtCO2	0.212	0.197	0.231	0.047	0.026	0.018	1
SpO2	0.060	0.260	0.316*£	-0.054	-0.152	-0.125	0.482*§	1
InspISO	0.051	0.174	0.009	0.104	0.117	0.050	0.414*§	0.177	1
FeISO	-0.172	0.298	-0.127	-0.073	-0.024	-0.086	0.107	-0.008	0.752*∂	1
Sap	-0.070	0.011	0.167	0.536*§	0.468*§	0.505*§	0.058	0.075	-0.012	0.134	1
CPP	0.206	-0.481*§	-0.286	0.045	0.106	0.103	-0.054	-0.173	0.049	-0.213	-0.806*∂	1

£ = Weak correlation r<0.39, § = moderate correlation r>0.4<0.69, ∂ = strong correlation r>0.7<1.0; * significative values 5%, in these the superscript symbol represents the strength of the correlation.

Table 3. Mean and standard deviation of the variables body weight, measured length of nuchal ridge to iliac tuberosity, infused contrast volume, pressure volume-index (PVI), subarachnoid pressure (Sap0) and maximum subarachnoid pressure (SaPmax), obtained from the experimental model of ovine submitted to lumbar myelography and gauging subarachnoid pressure

Variable	Mean	Standard deviation
Body weight (kg)	44.68	±5.76
Lenght (cm)	78.87	±5.64
Volume (mL)	17.87	±2.30
PVI (mL)	17.91	±3.62
Sap0 (mmHg)	11.12	±4.16
Sapmax (mmHg)	101.87	±22.54

Table 4. Pearson correlation between the variables: body weight, length, contrast volume and pressure volume-index (PVI) exposing the r value of the experimental model of ovine submitted to lumbar myelography and subarachnoid pressure measurement

	Body weight	Lenght	Volume	PVI
Body weight	1
Lenght	0.491	1
Volume	1*^∂	0.491	1
PVI	0.756*^∂	0.410	0.756*^∂	1

£ = Weak correlation r<0.39, § = moderate correlation r>0.4<0.69, ∂ = strong correlation r>0.7<1.0; * significative values 5%, in these the superscript symbol represents the strength of the correlation.

Table 5. Relation of pressure volume-index (PVI) values, body weight, contrast volume and dose required to increase maximal subarachnoid pressure (SaPmax) at 40, 50 and 60mmHg as a theoretical limit of pressure of the experimental model of ovine submitted to lumbar myelography and check of subarachnoid pressure

Body weight	PVI	SaPmax 40mmHg		SaPmax 50mmHg		SaPmax 60mmHg
kg	mL	mL	mL/kg	mL	mL/kg	mL	mL/kg
30	10.98	6.10	0.20	7.17	0.24	8.04	0.27
32	11.89	6.61	0.21	7.76	0.24	8.70	0.27
34	12.80	7.12	0.21	8.36	0.25	9.37	0.28
36	13.71	7.62	0.21	8.95	0.25	10.04	0.28
38	14.62	8.13	0.21	9.55	0.25	10.70	0.28
40	15.53	8.64	0.22	10.14	0.25	11.37	0.28
42	16.45	9.14	0.22	10.74	0.26	12.04	0.29
44	17.36	9.65	0.22	11.33	0.26	12.71	0.29
46	18.27	10.16	0.22	11.93	0.26	13.37	0.29
48	19.18	10.66	0.22	12.52	0.26	14.04	0.29
50	20.09	11.17	0.22	13.12	0.26	14.71	0.29
52	21.00	11.68	0.22	13.71	0.26	15.37	0.30
54	21.91	12.18	0.23	14.31	0.26	16.04	0.30
56	22.83	12.69	0.23	14.90	0.27	16.71	0.30
58	23.74	13.20	0.23	15.50	0.27	17.38	0.30
60	24.65	13.70	0.23	16.09	0.27	18.04	0.30

P V I (m L) = \frac{Δ V (m L)}{\log_10 □ [\frac{S a P \max (m m H g)}{S a p 0 (m m H g)}]}

Como citar

copiar

Colégio Brasileiro de Patologia Animal - CBPA Pesquisa Veterinária Brasileira, Caixa Postal 74.591, 23890-000 Rio de Janeiro, RJ, Brasil, Tel./Fax: (55 21) 2682-1081 - Rio de Janeiro - RJ - Brazil
E-mail: pvb@pvb.com.br

Acompanhe os números deste periódico no seu leitor de RSS

Versão para download de PDF

PDF

Inglês

Versões e tradução automática

Versão original do texto

English

Tradução automática

Google Translator
Microsoft Translator

Como citar

RIS

BIBTEX

Outros formatos de citação e exportação:

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
E-mail: scielo@scielo.org

Leia a Declaração de Acesso Aberto

Métricas

Efeitos da mielografia lombar na pressão subaracnoidea e nos parâmetros cardiorrespiratórios em ovelhas saudáveis

PlumX

Mensagem

[1] *Corresponding author: lrmesquita@yahoo.com.br