Evaluation of the Effect of the Intensity and Occurrence of Postoperative Pain of Resin-Based and Bioceramic Root Canal Sealers: A Systematic Review and Meta-Analysis of Randomized Controlled Trial Studies

Jamali, Samira; Darvish, Maryam; Nasrabadi, Navid; Jafarizadeh, Sara

doi:10.1590/pboci.2021.082

Samira Jamali Correspondence: Samira Jamali, Department of Endodontics, Stomatological Hospital, College of Stomatology, Xi'an Jiaotong University, Shaanxi 710004, PR China. E-mail: samira.jamali90@yahoo.com

Department of Endodontics, Stomatological Hospital, College of Stomatology, Xi'an Jiaotong University, Shaanxi 710004, PR China.

http://orcid.org/0000-0003-3803-1235

Maryam Darvish

Department of Endodontics, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.

http://orcid.org/0000-0002-0622-4895

Navid Nasrabadi

Department of Endodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

http://orcid.org/0000-0002-6365-6619

Sara Jafarizadeh

School of Dentistry, Islamic Azad University, Tabriz Branch, Tabriz, Iran.

http://orcid.org/0000-0001-5196-0296

Correspondence: Samira Jamali, Department of Endodontics, Stomatological Hospital, College of Stomatology, Xi'an Jiaotong University, Shaanxi 710004, PR China. E-mail: samira.jamali90@yahoo.com

Academic Editor: Yuri Wanderley Cavalcanti

Authors’ Contributions

SJ https://orcid.org/0000-0003-3803-1235 Conceptualization, Methodology, Software, Validation, Formal Analysis, Investigation, Writing - Original Draft, Writing - Review and Editing, Visualization and Supervision.

MD https://orcid.org/0000-0002-0622-4895 Writing - Original Draft and Writing - Review and Editing.

NN https://orcid.org/0000-0002-6365-6619 Writing - Original Draft and Writing - Review and Editing.

SJ https://orcid.org/0000-0001-5196-0296 Writing - Original Draft and Writing - Review and Editing.

All authors declare that they contributed to critical review of intellectual content and approval of the final version to be published.

Conflict of Interest

The authors declare no conflicts of interest.

PICO OR PECO Strategy	Description
P	Population/ Patient: Patients requiring root canal retreatment
E	Exposure/ Intervention: Resin-based sealer (AH Plus) /Total Fill BC
C	Comparison: AH Plus vs. Bioceramic-based sealers
O	Outcome: Postoperative Pain Scores

Study	Design	No. of Patients		Age^* * In Years; RCT: Randomized Controlled Trial; VAS: Visual Analog Scale; NA: No information provided by the authors. (Mean)	No. of Teeth	Scale	Root Canal Sealers	Follow-up
Study	Design	Male	Female		No. of Teeth	Scale	Root Canal Sealers	Follow-up
Ferreira et al. [²²[22] Ferreira ND, Gollo EK, Boscato N, Arias A, Silva EJ. Postoperative pain after root canal filling with different endodontic sealers: a randomized clinical trial. Braz Oral Res 2020; 34. https://doi.org/10.1590/1807-3107bor-2020.vol34.0069 https://doi.org/10.1590/1807-3107bor-202... ]	RCT	57		41	60	VAS	AH Plus, MTA Fillapex, and EndoFill	24 h, 48 h, and 7 days
	RCT	17	40	41	60	VAS	AH Plus, MTA Fillapex, and EndoFill	24 h, 48 h, and 7 days
Fonseca et al. [²³[23] Fonseca B, Coelho MS, da Silveira Bueno CE, Fontana CE, De Martin AS, Rocha DG. Assessment of extrusion and postoperative pain of a bioceramic and resin-based root canal sealer. Eur J Dent 2019; 13(3):343-8. https://doi.org/10.1055/s-0039-3399457 https://doi.org/10.1055/s-0039-3399457... ]	RCT	64		38	64	VAS	AH Plus and Premixed Sealer + BC	24 h, 48 h, and 7 days
	RCT	26	38	38	64	VAS	AH Plus and Premixed Sealer + BC	24 h, 48 h, and 7 days
Graunaite et al. [⁷[7] Graunaite I, Skucaite N, Lodiene G, Agentiene I, Machiulskiene V. Effect of resin-based and bioceramic root canal sealers on postoperative pain: a split-mouth randomized controlled trial. J Endod 2018; 44(5):689-93. https://doi.org/10.1016/j.joen.2018.02.010 https://doi.org/10.1016/j.joen.2018.02.0... ]	RCT	61		49.5	122	VAS	AH Plus Gutta-Percha Point, Total Fill Sealer and a Total Fill BC Point	24 h, 48 h, and 7 days
	RCT	25	36	49.5	122	VAS		24 h, 48 h, and 7 days
Paz et al. [²⁴[24] Paz AB. Evaluation of postoperative pain after using bioceramic materials as endodontic sealers: randomized control clinical trial (Doctoral dissertation). 2017.]	RCT	30		NA	30	VAS	AH Plus and BioRoot	24 h, 48 h, and 7 days
	RCT	NA		NA	30	VAS	AH Plus and BioRoot	24 h, 48 h, and 7 days

Study	Random Sequence Generation	Allocation Concealment	Blinding of Participants and Personnel	Blinding of Outcome Assessment	Incomplete Outcome Data	Selective Reporting	Total Score
Ferreira et al. [²²[22] Ferreira ND, Gollo EK, Boscato N, Arias A, Silva EJ. Postoperative pain after root canal filling with different endodontic sealers: a randomized clinical trial. Braz Oral Res 2020; 34. https://doi.org/10.1590/1807-3107bor-2020.vol34.0069 https://doi.org/10.1590/1807-3107bor-202... ]							5
Fonseca et al. [²³[23] Fonseca B, Coelho MS, da Silveira Bueno CE, Fontana CE, De Martin AS, Rocha DG. Assessment of extrusion and postoperative pain of a bioceramic and resin-based root canal sealer. Eur J Dent 2019; 13(3):343-8. https://doi.org/10.1055/s-0039-3399457 https://doi.org/10.1055/s-0039-3399457... ]							4
Graunaite et al. [⁷[7] Graunaite I, Skucaite N, Lodiene G, Agentiene I, Machiulskiene V. Effect of resin-based and bioceramic root canal sealers on postoperative pain: a split-mouth randomized controlled trial. J Endod 2018; 44(5):689-93. https://doi.org/10.1016/j.joen.2018.02.010 https://doi.org/10.1016/j.joen.2018.02.0... ]							6
Paz et al. [²⁴[24] Paz AB. Evaluation of postoperative pain after using bioceramic materials as endodontic sealers: randomized control clinical trial (Doctoral dissertation). 2017.]							4

[1] Correspondence: Samira Jamali, Department of Endodontics, Stomatological Hospital, College of Stomatology, Xi'an Jiaotong University, Shaanxi 710004, PR China. E-mail: samira.jamali90@yahoo.com

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Evaluation of the Effect of the Intensity and Occurrence of Postoperative Pain of Resin-Based and Bioceramic Root Canal Sealers: A Systematic Review and Meta-Analysis of Randomized Controlled Trial Studies

ABSTRACT

Objective:

Material and Methods:

Results:

Conclusion: