The Influence of the First Thousand Days of Life on Establishing Determinant Behaviors for Dental Caries in Childhood

Martins, Luiz Gustavo Teixeira; Traebert, Eliane; Lunardelli, Abelardo Nunes; Lunardelli, Sandra Espíndola; Traebert, Jefferson

doi:10.1590/pboci.2021.133

Luiz Gustavo Teixeira Martins

Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, SC, Brazil.

http://orcid.org/0000-0003-0898-1440

Eliane Traebert

Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, SC, Brazil.

http://orcid.org/0000-0001-9667-7216

Abelardo Nunes Lunardelli

Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, SC, Brazil.

http://orcid.org/0000-0002-3052-8020

Sandra Espíndola Lunardelli

Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, SC, Brazil.

http://orcid.org/0000-0002-7836-6083

Jefferson Traebert Correspondence: Jefferson Traebert, Avenida Pedra Branca, 25, Palhoça, SC, Brasil. 88270-132. E-mail: jefferson.traebert@gmail.com

Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, SC, Brazil.

http://orcid.org/0000-0002-7389-985X

Correspondence: Jefferson Traebert, Avenida Pedra Branca, 25, Palhoça, SC, Brasil. 88270-132. E-mail: jefferson.traebert@gmail.com

Academic Editor: Burak Buldur

Authors’ Contributions

LGTM https://orcid.org/0000-0003-0898-1440 Conceptualization, Methodology, Formal Analysis, Investigation, Data Curation, Writing - Original Draft and Writing - Review and Editing.

ET https://orcid.org/0000-0001-9667-7216 Methodology, Writing - Review and Editing, Supervision and Project Administration.

ANL https://orcid.org/0000-0002-3052-8020 Methodology, Writing - Review and Editing, Supervision and Project Administration.

SEL https://orcid.org/0000-0002-7836-6083 Methodology, Writing - Review and Editing, Supervision and Project Administration.

JT https://orcid.org/0000-0002-7389-985X Conceptualization, Methodology, Formal Analysis, Investigation, Data Curation, Writing - Original Draft and Writing - Review and Editing.

All authors declare that they contributed to critical review of intellectual content and approval of the final version to be published.

Conflict of Interest

The authors declare no conflicts of interest.

Variables	RR_c	CI 95%	p-value	RR_a	CI 95%	p-value
Socioeconomic Status
Mother’s Schooling When the Child was Born			0.001			0.041
> 8 Years	1.00			1.00
≤ 8 Years	2.54	1.61-4.02		1.81	1.02-3.21
Father’s Schooling When the Child was Born			0.007
> 8 Years	1.00
≤ 8 Years	1.98	1.20-3.25		*
Mother’s Occupation When the Child was Born			0.075			0.754
With Income	1.00			1.00
Without Income	1.49	0.96-2.33		1.09	0.62-1.92
Father’s Occupation When the Child was Born			0.061
With Income	1.00
Without Income	2.10	0.96-4.57
Steady Partner When the Child was Born
Yes	1.00			*
No	1.02	0.44-2.34	0.962
Related to Pregnancy
Teenage Pregnancy			0.780
≥ 20 Years Old	1.00
10 to 19 Years Old	1.08	0.61-1.89
Prenatal Consultation			0.236
Yes	1.00
No	2.01	0.63-6.36
Number of Prenatal Consultations			0.276
≥ 6	1.00
< 5	1.90	0.59-6.05
Use of Alcohol While Pregnant			0.003			0.534
No	1.00			1.00
Yes	2.55	1.38-4.71		1.35	0.52-3.49
Smoking While Pregnant			0.081			0.747
No	1.00			1.00
Yes	1.61	0.94-2.75		1.08	0.41-1.86
Use of Illicit Drugs While Pregnant			0.036			0.127
No	1.00			1.00
Yes	2.93	1.07-8.01		3.19	0.71-14.21
Infectious Diseases While Pregnant			0.786
No	1.00
Yes	1.06	0.66-1.70
Gestational Age			0.658
37 to 41 Weeks	1.00
< 37 or ≥ 42 Weeks	1.13	0.64-1.98
Route of Delivery			0.221
Vaginal	1.00
Cesarean	1.34	0.83-2.14
Related to Children up to 2 Years Old
Child’s Gender			0.041			0.060
Female	1.00			1.00
Male	1.65	1.02-2.69		1.74	0.97-3.09
Birth Weight			0.386
≥ 2500g	1.00
< 2499g	1.86	0.45-7.60
Apgar 1^st Minute			0.466
≥ 8	1.00
< 7	0.73	0.31-1.70
Gastroesophageal Reflux			0.250
No	1.00
Yes	1.53	0.74-3.18
Infectious Diseases			0.064			0.311
No	1.00			1.00
Yes	2.20	0.95-5.09		1.56	0.65-3.74
Use of Antibiotics			0.370
No	1.00
Yes	1.23	0.77-1.97
Use of Medication for more than 30 Consecutive Days			0.397
No	1.00
Yes	1.26	0.73-2.19
Hospitalization for More Than 2 Days			0.974
No	1.00
Yes	1.01	0.55-1.82
Hospitalization During the First 29 Days of Life			0.988
Yes	1.01	0.40-2.50
No	1.00
Nursery Frequency			0.529
No	1,00
Yes	1,16	0.72-1.86

Variables	RR_c	CI 95%	p-value	RR_a	CI 95%	p-value
Socioeconomic Status
Mother’s Schooling When the Child was Born			0.008			0.049
>8 Years	1.00			1.00
≤ 8 Years	2.02	1.19-3.41		2.05	1.01-4.17
Father’s Schooling When the Child was Born			0.013
>8 Years	1.00
≤ 8 Years	2.09	1.17-3.75		*
Mother’s Occupation When the Child was Born			0.234
With Income	1.00
Without Income	1.35	0.82-2.23
Father’s Occupation When the Child was Born			0.437
With Income	1.00
Without Income	1.49	0.54-4.12
Steady Partner When the Child was Born			0.150			0.550
Yes	1.00			1.00
No	1.72	0.82-3.61		1.39	0.47-4.13
Related to Pregnancy
Teenage Pregnancy			0.220
≥ 20 Years Old	1.00
10 to 19 Years Old	1.55	0.76-3.14
Prenatal Consultation			0.843
Yes	1.00
No	1.22	0.16-8.80
Number of Prenatal Consultations			0.095
≥ 6	1.00
< 5	1.89	0.89-4.00		*
Use of Alcohol While Pregnant			0.052			0.298
No	1.00			1.00
Yes	2.08	0.99-4.37		1.76	0.60-1.13
Smoking While Pregnant			0.550
No	1.00
Yes	1.22	0.63-2.33
Use of Illicit Drugs While Pregnant			0.926
No	1.00
Yes	1.09	0.15-7.91
Infectious Diseases While Pregnant			0.382
No	1.00
Yes	1.26	0.74-2.12
Gestational Age			0.436
37 to 41 Weeks	1.00
< 37 or ≥ 42 Weeks	1.26	0.70-2.27
Route of Delivery			0.038			0.042
Vaginal	1.00			1.00
Cesarean	0.89	0.70-0.97		0.42	0.18-0.97
Related to Children up to 2 Years Old
Child’s Gender			0.147
Female	1.00
Male	1.50	0.86-2.62		*
Birth Weight			0.161
≥ 2500 g	1.00
< 2499 g	1.93	0.76-4.87
Apgar 1^st Minute			0.484
≥ 8	1.00
< 7	1.66	0.40-6.87
Gastroesophageal Reflux			0.364
No	1.00
Yes	1.33	0.71-2.50
Infectious Diseases			0.036			0.165
No	1.00			1.00
Yes	3.47	1.08-11.12		2.77	0.66-11.6
Use of Antibiotics			0.551
No	1.00
Yes	1.17	0.69-1.98
Use of Medication for More than 30 Consecutive Days			0.889
No	1.00
Yes	1.04	0.54-2.00
Hospitalization for More than 2 Days			0.117			0.968
No	1.00			1.00
Yes	1.58	0.89-2.83		1.01	0.41-2.52
Hospitalization During the First 29 Days of Life			0.177
Yes	3.91	0.54-28.32
No	1.00
Nursery Frequency			0.799
No	1.00
Yes	1.07	0.62-1.82

Variables	RR_c	CI 95%	p-value	RR_a	CI 95%	p-value
Socioeconomic Status
Mother’s Schooling When the Child was Born			< 0.001			0.028
> 8 Years	1.00			1.00
≤ 8 Years	2.19	1.57-3.06		1.69	1.05-2.72
Father’s Schooling When the Child was Born			0.283
>8 Years	1.00
≤ 8 Years	1.22	0.84-1.77
Mother’s Occupation When the Child was Born			0.005			0.021
With Income	1.00			1.00
Without Income	1.61	1.15-2.25		1.75	1.08-2.82
Father’s Occupation When the Child was Born			0.735
With Income	1.00
Without Income	1.14	0.53-2.43
Steady Partner When the Child was Born			0.040			0.339
Yes	1.00			1.00
No	1.67	1.02-2.74		1.47	0.66-3.27
Related to Pregnancy
Teenage Pregnancy			0.297
≥ 20 Years Old	1.00
10 to 19 Years Old	1.22	0.83-1.78
Prenatal Consultation			0.454
Yes	1.00
No	1.46	0.54-3.94
Number of Prenatal Consultations			0.600
≥ 6	1.00
< 5	1.19	0.60-2.35
Use of Alcohol While Pregnant			0.005			0.204
No	1.00			1.00
Yes	2.04	1.24-3.34		1.57	0.78-3.17
Smoking While Pregnant			0.096			0.230
No	1.00			1.00
Yes	1.41	0.94-2.11		1.41	0.80-2.50
Use of Illicit Drugs While Pregnant			0.128			0.786
No	1.00			1.00
Yes	1.99	0.82-4.87		1.32	0.17-9.89
Infectious Diseases While Pregnant			0.147			0.644
No	1.00			1.00
Yes	1.28	0.91-1.79		1.11	0.69-1.78
Gestational Age			0.761
37 to 41 Weeks	1.00
< 37 or ≥ 42 Weeks	1.07	0.68-1.67
Route of Delivery			0.707
Vaginal	1.00
Cesarean	1.07	0.74-1.54
Related to Children up to 2 Years Old
Child’s Gender			0.905
Female	1.00
Male	1.02	0.71-1.46
Birth Weight			0.494
≥ 2500 g	1.00
< 2499 g	1.28	0.62-2.63
Apgar 1^st Minute			0.010			0.059
≥ 8	1.00			1.00
< 7	0.48	0.28-0.83		0.54	0.29-1.02
Gastroesophageal Reflux			0.750
No	1.00
Yes	1.08	0.67-1.73
Infectious Diseases			0.316
No	1.00
Yes	1.29	0.77-2.16
Use of Antibiotics			0.127			0.422
No	1.00			1.00
Yes	1.29	0.92-1.80		1.21	0.75-1.94
Use of Medication for More than 30 Consecutive Days			0.270
No	1.00
Yes	1.25	0.83-1.88
Hospitalization for More than 2 Days			0.350
No	1.00
Yes	1.21	0.80-1.83
Hospitalization During the First 29 Days of Life			0.590
No	1.00
Yes	1.23	0.57-2.64
Nursery Frequency			0.442
No	1.00
Yes	1.15	0.80-1.65

Variables	RR_c	CI 95%	p-value	RR_a	CI 95%	p-value
Socioeconomic Status
Mother’s Schooling When the Child was Born			0.068
> 8 Years	1.00
≤ 8 Years	1.36	0.97-1.90		*
Father’s Schooling When the Child was Born			0.306
> 8 Years	1.00
≤ 8 Years	1.17	0.86-1.58
Mother’s Occupation When the Child was Born			0.024			0.051
With Income	1.00			1.00
Without Income	1.37	1.04-1.80		1.41	0.98-2.01
Father’s Occupation When the Child was Born			0.335
With Income	1.00
Without Income	1.44	0.68-3.07
Steady Partner When the Child was Born			0.357
Yes	1.00
No	1.34	0.71-2.54
Related to Pregnancy
Teenage Pregnancy			0.930
≥ 20 Years Old	1.00
10 to 19 Years Old	1.01	0.72-1.43
Prenatal Consultation			0.281
Yes	1.00
No	1.56	0.69-3.51
Number of Prenatal Consultations			0.260
≥ 6	1.00
< 5	1.41	0.77-2.60
Use of Alcohol While Pregnant			0.441
No	1.00
Yes	1.32	0.65-2.67
Smoking While Pregnant			0.317
No	1.00
Yes	1.24	0.81-1.89
Use of Illicit Drugs While Pregnant			0.802
No	1.00
Yes	1.15	0.37-3.61
Infectious Diseases While Pregnant			0.224
No	1.00
Yes	1.19	0.89-1.59
Gestational Age			0.096			0.202
37 to 41 Weeks	1.00			1.00
< 37 or ≥ 42 Weeks	1.43	0.93-2.20		1.34	0.85-2.11
Route of Delivery			0.973
Vaginal	1.00
Cesarean	1.00	0.73-1.38
Related to Children up to 2 Years Old
Child’s Gender			0.818
Female	1.00
Male	1.03	0.75-1.42
Birth Weight			0.363
≥ 2500 g	1.00
< 2499 g	1.51	0.62-3.68
Apgar 1^st Minute			0.439
≥ 8	1.00
< 7	0.77	0.40-1.47
Gastroesophageal Reflux			0.098			0.046
No	1.00			1.00
Yes	1.33	0.94-1.88		2.00	1.01-3.98
Infectious Diseases			0.089			0.462
No	1.00			1.00
Yes	1.33	0.95-1.86		1.17	0.76-1.82
Use of Antibiotics			0.533
No	1.00
Yes	1.09	0.82-1.45
Use of Medication for More than 30 Consecutive Days			0.883
No	1.00
Yes	1.02	0.71-1.48
Hospitalization for More than 2 Days			0.041			0.044
No	1.00			1.00
Yes	1.60	1.02-2.50		1.98	1.03-3.96
Hospitalization During the First 29 Days of Life			0.455
No	1.00
Sim	1.29	0.65-2.53
Nursery Frequency			0.105
No	1.00
Yes	1.27	0.95-1.71		*

[1] Correspondence: Jefferson Traebert, Avenida Pedra Branca, 25, Palhoça, SC, Brasil. 88270-132. E-mail: jefferson.traebert@gmail.com

Brasil

Brasil

The Influence of the First Thousand Days of Life on Establishing Determinant Behaviors for Dental Caries in Childhood

ABSTRACT

Objective:

Material and Methods:

Results:

Conclusion: