Comparative angiotomographic study of swine vascular anatomy: contributions to research and training models in vascular and endovascular surgery

Abstract

Background

Medium and large animal models allow researchers to evaluate the efficacy and safety of cardiovascular procedures in systems that resemble human anatomy and can be used to simulate scenarios for training purposes. Although porcine models have been used extensively, many physiological and anatomical features remain unknown or only superficially described.

Objectives

To describe the normal porcine vascular anatomy on computed tomography scans, compare it to human vascular anatomy, and discuss the application of porcine models for open and endovascular procedures.

Methods

Three male Landrace pigs underwent computed tomography. The vascular anatomy of the neck, thorax, abdomen, and limbs was analyzed and described; relevant similarities and differences between porcine and human vascular anatomies and the implications for vascular procedures in pigs are highlighted.

Results

The carotid territory, aortic arch, and terminal aorta branches all show marked differences in pigs compared to their human counterparts. Compressions of both left renal and common iliac veins were detected, analogous to those seen in human Nutcracker and May-Thurner syndromes. Vascular measurements (diameters, lengths, and angles) of several different porcine territories are presented.

Conclusions

The data presented should be useful for planning preclinical trials and basic research and for refining surgical training using porcine models in vascular fields.

Keywords:
pigs; blood vessels; vascular surgical procedures; anatomy, comparative; endovascular procedures; computed tomography angiography