IL-4-C-590T locus polymorphism and susceptibility to asthma in children: a meta-analysis

Jin, Xiaosheng; Zheng, Jisheng

doi:10.1016/j.jped.2020.05.005

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Sumário

Review articles • J. Pediatr. (Rio J.) 97 (3) • May-Jun 2021 • https://doi.org/10.1016/j.jped.2020.05.005 copy

IL-4-C-590T locus polymorphism and susceptibility to asthma in children: a meta-analysis

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Objectives

The study aimed to evaluate the link between the IL-4-C590T polymorphism and asthma susceptibility in children by meta-analysis.

Sources

The study collected all the case-control studies found in PubMed, Embase, CNKI, Wanfang, VIP, and other databases until September 2019. Stata v. 15.0 was used to conduct meta-analysis, calculate the combined OR and its 95% CI, and then conduct subgroup analysis.

Summary of the findings

Seven studies were included in the study, containing 860 cases and 810 controls. Relative to the C allele, the T allele at the IL-4-C590T locus was associated with susceptibility to asthma in children (OR = 1.45, 95% CI: 1.05–2.01). The results of ethnicity subgroup analysis showed that there was statistical significance, with OR = 1.61 (95% CI: 1.01–2.57) in the Asian population. In the dominant and recessive genetic models, the overall test and the Asian population subgroup analysis were statistically significant. In the homozygous model, there was statistical significance, but no statistical significance in heterozygous model.

Conclusions

The IL-4-C590T polymorphism was associated with asthma susceptibility, and T allele and TT genotype may increase the risk of asthma susceptibility in children, especially in the Asian population.

Keywords
IL-4; rs2243250; Asthma; Polymorphism; Meta-analysis

First author	Year	Country	Gene detection method	Age group	Case			Control			HWE	NOS score
First author	Year	Country	Gene detection method	Age group	TT	CT	CC	TT	CT	CC	HWE	NOS score
Noguchi²⁰20 Noguchi E, Shibasaki M, Arinami T, Takeda K, Yokouchi Y, Kawashima T, et al. Association of asthma and the interleukin-4 promoter gene in Japanese. Clin Exp Allergy. 1998;28:449-453.	1998	Japan	PCR-RFLP	Children	56	37	4	101	97	17	0.342	8
Lee¹⁹19 Lee SG, Kim BS, Kim JH, Lee SY, Choi SO, Shim JY, et al. Gene-gene interaction between interleukin-4 and interleukin-4 receptor alpha in Korean children with asthma. Clin Exp Allergy. 2004;34:1202-1208.	2004	Korea	PCR-RFLP	Children	169	77	9	68	29	3	0.966	8
Smolnikova²¹21 Smolnikova MV, Smirnova SV, Freidin MB, Tyutina OS. Immunological parameters and gene polymorphisms (C-590T IL4, C-597A IL10) in severe bronchial asthma in children from the Krasnoyarsk region, West Siberia. Int J Circumpolar Health. 2013;72:.	2013	Russia	PCR-RFLP	Children	3	25	36	1	19	30	0.304	8
Ramphul¹⁵15 Ramphul K, Lv J, Hua L, Liu QH, Fang DZ, Ji RX, et al. Single nucleotide polymorphisms predisposing to asthma in children of Mauritian Indian and Chinese Han ethnicity. Braz J Med Biol Res. 2014;47:394-397.	2014	China	PCR	Children	130	55	7	127	60	5	0.504	8
Zhang¹⁶16 Zhang JH, Zhou GH, Wei TT, Chang ZS. Association between the interleukin 4 gene -590C&T promoter polymorphism and asthma in Xinjiang Uighur children. Genet Mol Res. 2016;15:.	2016	China	PCR	Children	19	11	8	5	13	17	0.349	8
Narożna¹⁷17 Narożna B, Hoffmann A, Sobkowiak P, Schoneich N, Bręborowicz A, Szczepankiewicz A. Polymorphisms in the interleukin 4, interleukin 4 receptor and interleukin 13 genes and allergic phenotype: a case control study. Adv Med Sci. 2016;61:40-45.	2016	Poland	Real-time PCR	Children	5	55	117	3	53	133	0.376	8
Zhang¹⁸18 Zhang JH, Zhang M, Wang YN, Zhang XY. Correlation between IL-4 and IL-13 gene polymorphisms and asthma in Uygur children in Xinjiang. Exp Ther Med. 2019;17:1374-1382.	2018	China	PCR	Children	17	13	7	3	15	11	0.519	8

Genetic models	n	OR	95% CI	p	I² (%)	p for heterogeneity	Model	p for publication bias
Allelic model	7	1.45	1.05-2.01	0.025	68.6	0.004	REM	0.037
Asian	5	1.61	1.01-2.57	0.047	78.7	0.001	REM	0.023
Caucasian	2	1.21	0.87-1.69	0.252	0.0	0.976	FEM	NA
Dominant model	7	1.39	1.03-1.87	0.031	17.2	0.299	FEM	0.406
Asian	5	1.75	1.08-2.86	0.024	31.7	0.210	FEM	0.078
Caucasian	2	1.21	0.82-1.76	0.337	0.0	0.923	FEM	NA
Recessive model	7	1.76	1.07-2.92	0.027	64.0	0.011	REM	0.088
Asian	5	1.79	1.00-3.19	0.050	75.4	0.003	REM	0.003
Caucasian	2	1.96	0.58-6.65	0.282	0.0	0.834	FEM	NA
Homozygous model	7	2.32	1.08-4.98	0.031	52.0	0.052	REM	0.671
Asian	5	2.42	0.88-6.67	0.088	67.9	0.014	REM	0.235
Caucasian	2	2.05	0.60-7.01	0.253	0.0	0.842	FEM	NA
Heterozygous model	7	1.18	0.86-1.61	0.307	0.0	0.922	FEM	0.791
Asian	5	1.22	0.72-2.07	0.471	0.0	0.749	FEM	0.286
Caucasian	2	1.16	0.78-1.71	0.461	0.0	0.872	FEM	NA

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[1] * Corresponding author. zhengjisheng1234@163.com