ABSTRACT
The aim of the study was to compare the behavior of metabolic parameters, blood pressure, and obesity indicators in children and adolescents with and without insulin resistance. Sixty-one overweight children (6 to 18 years) underwent anthropometric measurements of body mass (BM), height and waist circumference (WC), blood pressure (BP), bioimpedance (relative (%F) and absolute fat (BF)), and blood collection for determination of glucose, insulin, and lipid profile (TG, CT, HDL-C, LDL-C). The BMI z-score was used to classify nutritional status and the HOMA-IR index (> 2.5) for insulin resistance. Participants were divided into two groups, insulin resistant (IR, n= 27) and non-insulin resistant (NIR, n= 33). Regardless of age, children and adolescents with excess weight and IR presented higher BM, WC, BMI, %F and BF (kg), TG, and plasma insulin than their NIR counterparts, who in turn presented higher LDL-C. The groups did not differ in nutritional status (BMI z-score); however, in the comparison between the undesired proportions of the metabolic components, only three presented alterations with significant differences between the groups (TC, LDL-C, and TG). It is concluded that IR influences the development of dyslipidemias in this age group, especially TG.
Keywords:
Obesity; Adolescents; Metabolism
Source: Authors