ABSTRACT
Pancreatic panniculitis (PP) is a rare manifestation of pancreatic disease, involving subcutaneous adipose tissue. We report two cases of this entity: a 37-year-old female patient with systemic lupus erythematosus (SLE) and an elderly woman with Crohn’s disease. These are two chronic autoimmune inflammatory diseases that can be uncommonly related to acute pancreatitis and that culminates in PP. We also provide a brief review of the treatment, diagnosis and morphology of the lesions, as well as the pathophysiology of the disease. The importance of histopathological analysis of lesion biopsies is highlighted as an important diagnostic tool.
Key words:
fat necrosis; pancreatitis; Crohn disease; lupus erythematosus systemic
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PP A) enzymatic necrosis of adipocytes in the involved areas, ghost cells and hemorrhagic foci (HE, 40×); B) lobular panniculitis with inflammatory infiltrate composed of histiocytes and neutrophils; there are still necrotic areas, cell debris and saponification (HE, 100×).PP: pancreatic panniculitis; HE: hematoxylin and eosin stain.
PP: pancreatic panniculitis; HE: hematoxylin and eosin stain; CT: computed tomography.