Oral pigmentations in Laugier-Hunziker syndrome: a case report and review of diagnostic criteria

Silva, Luiz Arthur B.; Mafra, Rodrigo P.; Oliveira, Patrícia T.; Medeiros, Ana Miryam C.; Pinto, Leão P.; Silveira, Éricka Janine D.

doi:10.5935/1676-2444.20180011

Acessibilidade / Reportar erro

Brasil

Jornal Brasileiro de Patologia e Medicina Laboratorial

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

PATHOLOGY, CASE REPORT • J. Bras. Patol. Med. Lab. 54 (1) • Jan-Feb 2018 • https://doi.org/10.5935/1676-2444.20180011 copy

Oral pigmentations in Laugier-Hunziker syndrome: a case report and review of diagnostic criteria

Pigmentações orais na síndrome de Laugier-Hunziker: relato de caso e revisão dos critérios de diagnóstico

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Laugier-Hunziker syndrome (LHS) is a rare mucocutaneous disorder, of unknown etiology, characterized by multiple hyperpigmented macules, dispersed mostly on the oral mucosa, occasionally associated with longitudinal ridging of the nails. The diagnosis requires exclusion of other conditions, such as Addison's disease and Peutz-Jeghers syndrome. We report a case of a 34-year-old male patient, presenting with hyperpigmented macules on the lips, buccal mucosa and palate, as well as mild dark striations on toenails. After careful clinical and laboratorial investigations, the diagnosis of LHS was established. Given the lack of aesthetic complaints and symptoms, no treatment was necessary.

Key words:
hyperpigmentation; mouth mucosa; skin abnormalities

Author	Sex	Age (years)	Anatomical location	Aspects of oral lesions	Other manifestations
Present study	M	34	Lip, buccal mucosa, palate	Hyperpigmented macules	Hyperpigmented longitudinal bands in toenails
Verma et al. (2017)⁽⁸8 Verma B, Behra A, Ajmal AK, Sen S. Laugier-Hunziker syndrome in a young female. Indian Dermatol Online J. 2017; 8(2): 148-50.⁾	F	19	Lip, tongue, palate	Hyperpigmented macules	Longitudinal melanonychia in finger and toenails
Bhoyrul et al. (2016)⁽⁹9 Bhoyrul B, Paulus J. Macular pigmentation complicating irritant contact dermatitis and viral warts in Laugier-Hunziker syndrome. Clin Exp Dermatol. 2016; 41(3): 294-6.⁾	F	48	Lip	Several brown to dark macules	Hyperpigmentation of fingers
Kaçar et al. (2016)⁽¹⁰10 Kaçar N, Yildiz CC, Demirkan N. Dermoscopic features of conjunctival, mucosal, and nail pigmentations in a case of Laugier-Hunziker syndrome. Dermatol Pract Concept. 2016; 6(1): 23-4.⁾	M	23	Lip	Multiple pigmentation	Longitudinal hyperpigmented bands in nails, punctiform pigmentation in the right eye
Lalosevic et al. (2015)⁽⁷7 Lalosevic J, Zivanovic D, Skiljevic D, Medenica L. Laugier-Hunziker syndrome - case report. An Bras Dermatol. 2015; 90(3): 223-5.⁾	F	63	Buccal mucosa,	Regular brown pigmentation	Longitudinal pigmented bands in finger and toenails
Mahmood et al. (2015)⁽³3 Mahmood T, Menter A. The Laugier-Hunziker syndrome. Proc (Bayl Univ Med Cent). 2015; 28(1): 41-2.⁾	F	46	Lip	Hyperpigmented macules	Longitudinal hyperpigmentation in finger and toenails; isolate macule in the conjunctiva
Ergun et al. (2013)⁽¹1 Ergun S, Saruhanoğlu A, Migliari DA, Maden I, Tanyeri H. Refractory pigmentation associated with Laugier-Hunziker syndrome following Er:YAG laser treatment. Case Rep Dent. 2013; 2013: 1-4.⁾	F	37	Lip, buccal mucosa, palate	Brown to dark pigmentation	-
Nikitakis et al. (2013)⁽⁵5 Nikitakis NG, Koumaki D. Laugier-Hunziker syndrome: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013; 116(1): 52-8.⁾	F	55	Lip, buccal mucosa	Multiple oral melanotic macules	Ill-defined striae in fingernails
Wang et al. (2012)⁽²2 Wang WM, Wang X, Duan N, Jiang HL, Huang XF. Laugier-Hunziker syndrome: a report of three cases and literature review. Int J Oral Sci. 2012; 4(4): 226-30.⁾	F	45	Lip, buccal mucosa, gingiva, tongue	Diffuse hyperpigmentation	Longitudinal hyperpigmentation in finger and toenails
	M	40	Gingiva	Widely diffuse pigmentation	Brown macule on conjunctiva
	M	36	Lip	Multiple oral melanotic macules	Brown macules in nails and interdigital spaces
Wondratsch et al. (2012)⁽⁶6 Wondratsch H, Feldmann R, Steiner A, Breier F. Laugier-Hunziker syndrome in a patient with pancreatic cancer. Case Rep Dermatol. 2012; 4(2): 174-6.⁾	F	61	Buccal mucosa, tongue	Confluent pigmented macules	Hyperpigmentation in vulva
Asati et al. (2011)⁽¹¹11 Asati DP, Tiwari S. Laugier-Hunziker syndrome. Indian J Dermatol Venereol Leprol. 2011; 77(4): 536.⁾	F	19	Lip, buccal mucosa, palate, tongue	Mild and multiple brown to dark macules, oval to irregular shape	Multiple freckles in skin of the periorbital region, nose, cheeks, fingertips and nails
Ma et al. (2011)⁽¹²12 Ma DL, Vano-Galvan S. Hyperpigmentation in Laugier-Hunziker syndrome. CMAJ. 2011; 183(12): 1402.⁾	F	60	Lip, buccal mucosa, tongue	Diffuse pigmentation	Longitudinal pigmented bands in nails
Sachdeva et al. (2011)⁽¹³13 Sachdeva S. Sachdeva S, Kapoor P. Laugier-Hunziker syndrome: a rare cause of oral and acral pigmentation. J Cutan Aesthet Surg. 2011; 4(1): 58-60.⁾	F	50	Lip, tongue	Brown macules	Brown macules in finger and toenails; darkened bands in nails
Jabbari et al. (2010)⁽¹⁴14 Jabbari A, Gonzalez ME, Franks Jr AG, Sanchez M. Laugier Hunziker syndrome. Dermatol Online J. 2010; 16(11): 23.⁾	F	45	Tongue	Hyperpigmented macules	Hyperpigmented macules in nails
Montebugn et al. (2010)⁽¹⁵15 Montebugnoli L, Grelli I, Cervellati F, Misciali C, Raone B. Laugier-Hunziker syndrome: an uncommon cause of oral pigmentation and a review of the literature. Int J Dent. 2010; 2010: 1-4.⁾	F	43	Lip, buccal mucosa,	Diffuse brown macules	Longitudinal pigmentation in nails
Rangwala et al. (2010)⁽⁴4 Rangwala S, Doherty CB, Katta R. Laugier-Hunziker syndrome: a case report and review of the literature. Dermatol Online J. 2010; 16(12): 9.⁾	M	77	Lip	Confluent brown macules	Bilateral melanonychia striata in finger and toenails
Sendagorta et al. (2010)⁽¹⁶16 Sendagorta E, Feito M, Ramírez P, Gonzalez-Beato M, Saida T, Pizarro A. Dermoscopic findings and histological correlation of the acral volar pigmented maculae in Laugier-Hunziker syndrome. J Dermatol. 2010; 37(11): 980-4.⁾	F	76	Lip, buccal mucosa, palate, tongue	Multiple brown to dark lenticular macules	Linear melanonychia in finger and toenails
Tamiya et al. (2010)⁽¹⁷17 Tamiya H, Kamo R, Sowa J, et al. Dermoscopic features of pigmentation in Laugier-Hunziker-Baran syndrome. Dermatol Surg. 2010; 36(1): 152-4.⁾	F	61	Lip, buccal mucosa,	Slightly brown to grayish blue macules, oval to irregular shape	Diffuse longitudinal melanonychia
Aliagaoglu et al. (2008)⁽¹⁸18 Aliagaoglu C, Yanik ME, Albayrak H, Güvenç SC, Yildirim U. Laugier-Hunziker syndrome: diffuse large hyperpigmentation on atypical localization. J Dermatol. 2008; 35(12): 806-7.⁾	M	51	Lip, buccal mucosa,	Multiple lenticular dark brown macules	Increased pigmentation in right pre-tibial area; pigmented macules in palmoplantar region
Kim et al. (2008)⁽¹⁹19 Kim EJ, Cho SH, Lee JD. A case of Laugier-Hunziker syndrome. Ann Dermatol. 2008; 20(3): 126-9.⁾	F	54	Lip, buccal mucosa, tongue	Confluent macules of brown to dark aspect	Longitudinal melanonychia in nails
Yago et al. (2008)⁽²⁰20 Yago K, Tanaka Y, Asanami S. Laugier-Hunziker-Baran syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 106(2): 20-5.⁾	M	39	Lip, buccal mucosa, tongue, palate	Multiple hyperpigmented macules	Well-defined brown macules in palmoplantar regions of toes and toenails
	M	68	Lip, buccal mucosa, tongue, palate	Multiple hyperpigmented macules	Multiple hyperpigmented macules in palmoplantar region; longitudinal pigmented bands in toenails
Gencoglan et al. (2007)⁽²¹21 Gencoglan G, Gerceker-Turk B, Kilinc-Karaarslan I, Akalin T, Ozdemir F. Dermoscopic findings in Laugier-Hunziker syndrome. Arch Dermatol. 2007; 143(5): 631-5.⁾	F	24	Lip, gingiva, tongue	Bluish to brown macules	Longitudinal hyperpigmented macule in the vulva; pigmented macules in palmoplantar area; melanonychia in toenails

Sociedade Brasileira de Patologia Clínica, Rua Dois de Dezembro,78/909 - Catete, CEP: 22220-040v - Rio de Janeiro - RJ, Tel.: +55 21 - 3077-1400 / 3077-1408, Fax.: +55 21 - 2205-3386 - Rio de Janeiro - RJ - Brazil
E-mail: jbpml@sbpc.org.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] CORRESPONDING AUTHOR. Éricka Janine Dantas da Silveira, Departamento de Odontologia; Universidade Federal do Rio Grande do Norte; Avenida Senador Salgado Filho, 1787; Lagoa Nova; CEP: 59056-000; Natal-RN, Brasil; Phone/Fax: +55 (84) 3215-4138; e-mail: ericka_janine@yahoo.com.br.