The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination

Hospital Municipal São José, Joinville, Santa Catarina, BrazilHospital Municipal São JoséBrazilJoinville, Santa Catarina, BrazilHospital Municipal São José, Joinville, Santa Catarina, Brazil

Centro de Diagnósticos Anatomopatológicos (CEDAP), Joinville, Santa Catarina, BrazilCentro de Diagnósticos Anatomopatológicos (CEDAP)BrazilJoinville, Santa Catarina, BrazilCentro de Diagnósticos Anatomopatológicos (CEDAP), Joinville, Santa Catarina, Brazil

http://orcid.org/0000-0003-1637-9118

Daniele Cristina F. Lousada

Hospital Municipal São José, Joinville, Santa Catarina, BrazilHospital Municipal São JoséBrazilJoinville, Santa Catarina, BrazilHospital Municipal São José, Joinville, Santa Catarina, Brazil

Karina M. P. A. Coelho

Paulo Henrique C. França

Universidade da Região do Joinville (Univille), Joinville, Santa Catarina, BrazilUniversidade da Região do Joinville (Univille)BrazilJoinville, Santa Catarina, BrazilUniversidade da Região do Joinville (Univille), Joinville, Santa Catarina, Brazil

CORRESPONDING AUTHOR Flora Ávila Adorno e-mail: floraaadorno@hotmail.com

CONFLICT OF INTEREST

The authors have no conflicts of interest to declare.

AUTHOR CONTRIBUTIONS

Adorno FA and Lousada DCF contributed equally to the study conception and design, acquisition and analysis of data, statistical analysis, and drafting of the manuscript. Coelho KMPA and França PHC critically reviewed the manuscript for intellectual content, as well as performed complementary data analysis and final approval.

SCIMAGO INSTITUTIONS RANKINGS

Hospital Municipal São José, Joinville, Santa Catarina, BrazilHospital Municipal São JoséBrazilJoinville, Santa Catarina, BrazilHospital Municipal São José, Joinville, Santa Catarina, Brazil

Figures | Tables

Figures (2)
Tables (1)

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FIGURE 1
Distribution of HPV-positive by hybrid capture cases for histological or colposcopy evaluation outcome within one-year of follow-up after identification of atypical squamous cells

HPV: human papillomavirus; DNA: deoxyribonucleic acid; SIL: squamous intraepithelial lesions; ASC: atypical squamous cells; HSIL: high-grade intraepithelial lesion; LSIL: low-grade intraepithelial lesion; *number of cases with histology/total number of cases.

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FIGURE 2
Distribution of HPV-negative by hybrid capture cases for histological or colposcopy evaluation outcome within one-year of follow-up after identification of atypical squamous cells

HPV: human papillomavirus; DNA: deoxiribonucleic acid; SIL: squamous intraepithelial lesions; ASC: atypical squamous cells; HSIL: high-grade intraepithelial lesion; LSIL: low-grade intraepithelial lesion; *number of cases with histology/total number of cases.

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TABLE
Sensitivity, specificity, positive and negative predictive values for HSIL and LSIL

FIGURE 1 Distribution of HPV-positive by hybrid capture cases for histological or colposcopy evaluation outcome within one-year of follow-up after identification of atypical squamous cells
HPV: human papillomavirus; DNA: deoxyribonucleic acid; SIL: squamous intraepithelial lesions; ASC: atypical squamous cells; HSIL: high-grade intraepithelial lesion; LSIL: low-grade intraepithelial lesion; *number of cases with histology/total number of cases.

FIGURE 2 Distribution of HPV-negative by hybrid capture cases for histological or colposcopy evaluation outcome within one-year of follow-up after identification of atypical squamous cells
HPV: human papillomavirus; DNA: deoxiribonucleic acid; SIL: squamous intraepithelial lesions; ASC: atypical squamous cells; HSIL: high-grade intraepithelial lesion; LSIL: low-grade intraepithelial lesion; *number of cases with histology/total number of cases.

TABLE Sensitivity, specificity, positive and negative predictive values for HSIL and LSIL

Parameters (%)	HSIL	LSIL	Both
Sensitivity	92	73	82.3
Specificity	64	63.1	69.3
Positive predictive value	20.9	17.2	38.1
Negative predictive value	98.7	95.7	94.4

HSIL: high-grade intraepithelial lesion; LSIL: low-grade intraepithelial lesion.

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The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination

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[1] CORRESPONDING AUTHOR Flora Ávila Adorno e-mail: floraaadorno@hotmail.com