Antimicrobial Potential of Soil/Sediment Mangrove Associated Fungi: A Review

Braga, Antonio Fernando V. C.; Rosário, Marcelino S. do; Gomes, Jakson Breno N.; Monteiro, Cristina de A.; Farias, Flavia A. C.; Rodrigues Filho, Edson; Cantanhede Filho, Antônio José

doi:10.21577/0103-5053.20240032

Antonio Fernando V. C. Braga

Antonio Fernando V. C. Braga graduated in Chemistry from the Federal Institute of Education, Science, and Technology of Maranhão, Bacabal campus. Master’s student in Chemistry at the Federal Institute of Maranhão, São Luís campus, Monte Castelo. He is a researcher in the area of Organic Chemistry, with emphasis on the chemistry of Natural Products, acting in the line of research in Biotechnology of Plants and Microorganisms with studies regarding the induction of metabolic routes in fungi, isolation, and identification of secondary metabolites of fungal origin.

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Programa de Pós-Graduação em Química, Instituto Federal de Educação, Ciência e Tecnologia do Maranhão, Avenida Getúlio Vargas 04, Monte Castelo, 65030-005 São Luís-MA, Brazil

Marcelino S. do Rosário

Marcelino S. do Rosário graduated in Chemistry from the State University of Maranhão (2020). He worked in the development and stability study of cosmetic emulsion containing vegetable oil, CNPq Scientific Initiation Scholarship (2017-2018). He participated in the preparation and characterization work of a photoprotective cosmetic emulsion based on vegetable oil, FAPEMA Scientific Initiation Scholar (2018-2019). In 2018, he carried out an internship at the Federal University of Rio de Janeiro in the galenic development laboratory of the Faculty of Pharmacy. He was a member of the Superintendence of Environmental Management (AGA-UEMA), UEMA extension fellow (2019-2020). He has a Master in Chemistry at the Federal University of Maranhão-UFMA (2021-2023). Currently studying for a PhD in Chemistry at the Institute of Chemistry at UNESP-Araraquara. He has experience in the field of chemistry and develops research in the area of natural products, acting in the isolation and identification of secondary metabolites, in addition to the search for natural alternatives with anti-leishmania potential.

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NuBBE, Departamento de Bioquímica e Química Orgânica, Instituto de Química, Universidade Estadual Paulista, 14800-900 Araraquara-SP, Brazil

Jakson Breno N. Gomes

Jakson Breno N. Gomes has experience in General Biology, with emphasis on General Biology, working mainly on the following topics: bioprospection, microbiology, antimicrobial, antivirulence, and fungal biodiversity.

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Departamento Acadêmico de Biologia, Instituto Federal de Educação, Ciência e Tecnologia do Maranhão, Avenida Getúlio Vargas 04, Monte Castelo, 65030-005 São Luís-MA, Brazil

Cristina de A. Monteiro

Cristina A. Monteiro graduated in Biological Sciences from the Federal University of Maranhão, with a Master’s degree in Genetics from the Faculty of Medicine of Ribeirão Preto and a PhD in Genetics from the Faculty of Medicine of Ribeirão Preto, in the specialty Molecular Genetics and Microorganisms. She was a Research Coordinator, Professor/Permanent Researcher of the Master’s Program in Microbial Biology, Coordinator of the Specialization in Clinical Microbiology, and Professor of the Biomedicine and Medicine Courses at Ceuma University. She is currently a Full Professor at the Federal Institute of Education, Science and Technology of Maranhão. She has experience in Genetics, with emphasis on Molecular and Microorganism Genetics, and in Microbiology, working mainly on the following topics: Virulence and Pathogenicity of Fungi and host interaction, Medical Mycology, Bioprospecting, Molecular Biology, Antimicrobial resistance.

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Departamento Acadêmico de Biologia, Instituto Federal de Educação, Ciência e Tecnologia do Maranhão, Avenida Getúlio Vargas 04, Monte Castelo, 65030-005 São Luís-MA, Brazil

Flavia A. C. Farias

Flavia A. C. Farias has PhD in Food Engineering and Science from São Paulo State University “Júlio de Mesquita Filho” (2017), Master’s degree in Phytosanitary Sciences from the Federal Rural University of Pernambuco (2004) and a Bachelor’s degree in Agronomic Engineering from the State University of Maranhão (2000). Currently, she is a D4 Professor in Basic, Technical, and Technological Education at the Federal Institute of Education, Science, and Technology -IFMA Campus São Luís-Monte Castelo.

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Departamento Acadêmico de Biologia, Instituto Federal de Educação, Ciência e Tecnologia do Maranhão, Avenida Getúlio Vargas 04, Monte Castelo, 65030-005 São Luís-MA, Brazil

Edson Rodrigues Filho

Edson Rodrigues Filho has Bachelor’s Degree in Chemistry from the Federal University of Uberlândia (1986), Master’s (1989), and PhD (1992) in Chemistry from the Federal University of São Carlos, Postdoctoral fellow at the University of Minnesota (Plant Pathology)-USA. Currently, he is a Full Professor at the Federal University of São Carlos, Department of Chemistry. He has experience in the area of Organic Chemistry, with emphasis on the Chemistry of Natural Products, working mainly on the following topics: Biosynthesis of microbial natural products; Biotransformation; Endophytic fungi, production of antibiotics and insecticides from filamentous fungi and actinomycetes; Short-step synthesis of molecules inspired by natural products; Specialist in analytical techniques Mass spectrometry, chromatography, and Nuclear Magnetic Resonance.

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Departamento de Química, Universidade Federal de São Carlos, CP 676, 13565-905 São Carlos-SP, Brazil

Antônio José Cantanhede Filho^** e-mail: prof.antoniofilho@ifma.edu.br

Antônio José Cantanhede Filho graduated in Industrial Chemistry and Degree in Chemistry from the Federal University of Maranhão, Master’s degree in Chemistry from the Paulista State University Júlio de Mesquita Filho (2002), PhD - LaBioMMi, at the Federal University of São Carlos-UFSCar (2019). He is a DIV-III professor (Associate III) at the Federal Institute of Maranhão-IFMA and Ad Hoc consultant for the Research Support Foundation of Maranhão (FAPEMA). He acts as researcher-coordinator in the Graduate Program in Chemistry (PPGQ-IFMA), with emphasis on Biotechnology of Natural Products, working mainly on the following topics: Induction of metabolic pathways of endophytic fungi, Isolation and identification of secondary metabolites of plants and microorganisms.

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Programa de Pós-Graduação em Química, Instituto Federal de Educação, Ciência e Tecnologia do Maranhão, Avenida Getúlio Vargas 04, Monte Castelo, 65030-005 São Luís-MA, Brazil

http://orcid.org/0000-0002-2009-2817

* e-mail: prof.antoniofilho@ifma.edu.br

Editor handled this article: Hector Henrique F. Koolen (Associate)

Species	Source	Major compounds	Antimicrobial activity microorganism	Potency	Reference
Penicillium sp. MA-37	soil	7-o-acetylsecopenicillide C (1)	Micrococcus luteus Escherichia coli	MIC 64.0 μg mL^-1 16.0 μg mL^-1	38
Penicillium sp. MA-37	soil	iso-monodictyphenone (2)	Aeromonas hydrophilia	8.0 μg mL^-1	39
Penicillium sp. ML226	sediment	penicitrinol J (3) penicitrinol K (4)	Staphylococcus aureus	inhibition zone 10 mm 9 mm	40
Penicillium bilaiae MA-267	soil	penicibilaene A (5) penicibilaene B (6)	Colletotrichum gloeosporioides	MIC 1.0 μg mL^-1 0.125 μg mL^-1	41
Penicillium simplicissimum MA-332	soil	penicisimpin A (7)	Escherichia coli Pseudomonas aeruginosa Vibrio parahaemolyticus Vibrio harveyi Colletotrichum gloeosprioides	MIC 4.0 μg mL^-1	42
Penicillium simplicissimum MA-332	soil	simpterpenoid A (8)	influenza neuraminidase Physalospora piricola	IC₅₀ 8.1 nM MIC 64.0 μg mL^-1	43
Penicillium janthinellum HK1-6	soil	penicilones B-D (9-11)	Methicillin-resistant Staphylococcus aureus	MIC 3.1-6.2 μg mL^-1	44
		penicilone G (12) penicilone H (13)	Staphylococcus aureus Enterococcus faecalis Enterococcus faecium Escherichia coli	MIC 3.1-50.0 μg mL^-1	45
		penijanthinone A (14)	Methicillin-resistant Staphylococcus aureus	MIC 3.1 μg mL^-1	45
Penicillium sp. HK1-22	soil	peninaphones A-C (15-17)	Staphylococcus aureus	MIC 12.5-50.0 µg mL^-1	46
Penicillium sp. HK1-22	soil	peninaphone C (17)	Rhizoctonia solani	-	46
Penicillium pinophilum SCAU037	soil	sch725680 (18)	Mycobacterium smegmatis Staphylococcus aureus	IC₅₀ 23.5 μM 2.6 μM	47
Penicillium ludwigii SCSIO 41408	sediment	adametizine C (19) adametizine A (20) DC1149B (21) outovirin B (22) pretrichodermamide E (23)	Erysipelothrix rhusiopathiae WH13013 Streptococcus suis SC19	MIC 50.0-100.0 μg mL^-1	48
Penicillium ludwigii SCSIO 41408	sediment	adametizine A (20)	Botrytis cinerea Septoria nodorum Berk	MIC 25.0 μg mL^-1	48
Penicillium camemberti OUCMDZ-1492	soil	3-deoxo-4b-deoxypaxilline (24) 4a-demethylpaspaline-4a-carboxylic acid (25) 4a-demethylpaspaline-3,4,4a-triol (26) 9,10-diisopentenylpaxilline (27) (6S,7R,10E,14E)-16-(1H-indol-3-yl)-2,6,10,14-tetramethylhexadeca-2,10,14-triene-6,7-diol (28) emindole SB (29) 21-isopentenylpaxilline (30) paspaline (31) paxilline (32)	H₁N₁	IC₅₀ 28.3 μM 38.9 μM 32.2 μM 73.3 μM 34.1 μM 26.2 μM 6.6 μM 77.9 μM 17.7 μM	49
Penicillium sp. OUCMDZ-4736	sediment	(-)-1,2,4,5-tetrahydroxy-7-((2R)-2-hydroxypropyl) anthracene-9,10-dione (33) methyl 6,8-dihydroxy-3-methyl-9-oxo-9H-xanthene-1-carboxylate (34)	HBV	dose dependent	50
Penicillium sp. IMB17-046	sediment	trypilepyrazinol (35)	HIV-1 HCV	4.6 µM 7.7 µM	51
		(+)-neocitreoviridin (36)	IAV	IC₅₀ 3.6 µM	51
		3β-hydroxyergosta-8,14,24(28)-trien-7-one (37)	HIV-1 I AV	IC₅₀ 3.5 µM 0.5 µM	51
		trypilepyrazinol (35) (+)-neocitreoviridin (36)	Helicobacter pylori	MIC 1.0-16.0 µg mL^-1	51
Penicillium raistrickii IMB17-034	sediment	raistrickindole A (38) raistrickin (39) sclerotigenin (40)	HCV	EC₅₀ 5.7 μM 7.0 μM 5.8 μM	52
Aspergillus versicolor HDN1009	soil	5-epi-asperdichrome (41)	Vibrio parahemolyticus Bacillus subtilis Mycobacterium phlei Pseudomonas aeruginosa Candida albicans	MIC 100-> 200 µM	22
Aspergillus ochraceus MA-15	soil	asperochrin A (42) chlorohydroaspyrone A (43) chlorohydroaspyrone B (44) chlorohydroasperlactone A (45) penicillic acid (46) (R)-7-hydroxymellein (47)	Aeromonas hydrophilia Vibrio anguillarum Vibrio harveyi	MIC 0.5-64.0 μg mL^-1	53
Aspergillus sp. DM94	soil	asperpyrone A (48) aurasperone A (49) aurasperone F (50) aurasperone B (51)	Helicobacter pylori G27 Helicobacter pylori HP159	MIC 4.0-16.0 μg mL^-1	54
Aspergillus terreus SCAU011	sediment	asperbutenolide D (52) (+)-3’,3’-di-(dimethylallyl)-butyrolactone II (53) aspernolide E (54) terrusnolide A (55)	Staphylococcus aureus	IC₅₀ 17.4-36.6 μM	55
Aspergillus terreus Gwq-48	soil	isoaspulvinone E (56) aspulvinone E (57) puvic acid (58)	H₁N₁	IC₅₀ 32.3 μg mL^-1 56.9 μg mL^-1 29.1 μg mL^-1	56
Aspergillus taichungensis ZHN-7-07	soil	aspergilazine A (59)	H₁N₁	dose dependent	57
Eurotium rubrum MA-150	soil	dihydroxyisoechinulin A (60)	Vibrio alginolyticus	MIC 16.0 μg mL^-1	58
Trichoderma sp. NPK2	sediment	crude extracts	Bacillus subtilis Vibrio cholerae	MIC 200.0 μg mL^-1	59
			Staphylococcus aureus Bacillus cereus	MIC 150.0 μg mL^-1	59
			Escherichia coli	MIC 125.0 μg mL^-1	59
			Vibrio parahaemolyticus Vibrio harveyi	MIC 200.0 μg mL^-1 150.0 μg mL^-1	59
Trichoderma sp. T-4-1	solo	trichodimerol (61) demethyltrichodimerol (62)	H₁N₁	IC₅₀ 0.5 μg mL^-1 0.9 μg mL^-1	60
Fusarium solani H915	sediment	fusariumester B (63)	Pestalotiopsis theae	MIC 50.0 μg per disk	61
Fusarium solani H915	sediment	hymeglusin (64) equisetin (65)	Pestalotiopsis theae Colletotrichum gloeosporioides	MIC 25.0 μg per disk	61
Fusarium solani H918	sediment	hymeglusin (64)	Pestalotiopsis theae	ED₅₀ 55 μM	62
Lasiodiplodia theobromae M4.2-2	sediment	(+)-(R)-de-O-methyl-lasiodiplodin (66)	Staphylococcus aureus Enterococcus faecium	MIC 25.0 μg mL^-1	63
Lasiodiplodia theobromae NSTRU-PN1.4	soil	(3R,4R)-4-acetyl-3-methyl-2(3H)-dihydrofuranone (67)	Cryptococcus neoformans	MIC 200.0 μg mL^-1	64
Cladosporium sp. PJX-41	soil	oxoglyantrypine (68) norquinadoline A (69) deoxynortryptoquivaline (70) deoxytryptoquivaline (71) tryptoquivaline (72) quinadoline B (73)	H₁N₁	IC₅₀ 85 μM 82 μM 87 μM 85 μM 89 μM 82 μM	65

[1] * e-mail: prof.antoniofilho@ifma.edu.br

Number of compounds
Activity
Anti-bacterial	Antifungal	Antiviral
39	12	30

Brasil

Brasil

Antimicrobial Potential of Soil/Sediment Mangrove Associated Fungi: A Review

Number of researches
Genus
Penicillium	Aspergillus	Eurotium	Trichoderma	Fusarium	Lasiodiplodia	Cladosporium
15	6	1	2	2	2	1