Efficacy of injectable platelet-rich fibrin in the erosive oral lichen planus: a split-mouth, randomized, controlled clinical trial

SAGLAM, Ebru; OZSAGIR, Zeliha Betul; UNVER, Tugba; ALINCA, Suzan Bayer; TOPRAK, Ali; TUNALI, Mustafa

doi:10.1590/1678-7757-2021-0180

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Brasil

Journal of Applied Oral Science

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Brasil

Español English

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Sumário

Original Article • J. Appl. Oral Sci. 29 • 2021 • https://doi.org/10.1590/1678-7757-2021-0180 copy

Efficacy of injectable platelet-rich fibrin in the erosive oral lichen planus: a split-mouth, randomized, controlled clinical trial^* * The 2-month follow-up datas of 13 patients of this study were presented as a poster presentation in Europerio 9, Rai, Amsterdam, and it was in press as a pilot study in the Medical Journal of Suleyman Demirel University.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Objective

Our study compared the effects of injectable platelet-rich fibrin (i-PRF) with those of corticosteroids in the treatment of erosive oral lichen planus (EOLP).

Methodology

This split-mouth study included 24 individuals diagnosed histopathologically with bilateral EOLP. One bilateral lesion was injected with i-PRF, whereas the other was injected with methylprednisolone acetate in four sessions at 15-day intervals. Visual analog scale (VAS) for pain and satisfaction, oral health impact profile scale-14, and the lesion size were used.

Results

The intragroup comparisons showed a significant decrease in VAS-pain and lesion size in both the i-PRF group (from 81.88±17.74 to 13.33±18.34, and from 4.79±0.41 to 1.88±1.08, respectively) and the corticosteroid group (from 80.21±17.35 to 23.33±26.81, and from 4.71±0.46 to 2.21±1.35, respectively) in the 6th month compared to baseline (p<0.001). Moreover, VAS-satisfaction increased significantly in both the i-PRF group (from 26.67±17.8 to 85.63±16.24) and the corticosteroid group (from 28.33±17.05 to 74.38±24.11) in the 6th month compared to baseline (p<0.001). However, no significant difference in any value occurred in the intergroup comparisons.

Conclusion

In patients with EOLP, both methods decreased pain and lesion size similarly, and both increased satisfaction. Therefore, the use of i-PRF may be considered an option in cases refractory to topical corticosteroid therapy. Biochemical and histopathological studies are required to reveal the mechanism of i-PRF action in EOLP treatment.

Corticosteroid; Oral lichen planus; Platelet-rich fibrin; Patient reported outcome measures; Wound healing

	VAS-pain			VAS-satisfaction Levels
	i-PRF Group	Corticosteroid Group		i-PRF Group	Corticosteroid Group
	Mean±SD	Mean±SD	p1	Mean±SD	Mean±SD	p1
	Med (Min-Max)	Med (Min-Max)		Med (Min-Max)	Med (Min-Max)
Baseline	81.88±17.74	80.21±17.35	0.666	26.67±17.8	28.33±17.05	0.691
Baseline	85 (40-100)	80 (40-100)	0.666	27.5 (0-70)	30 (0-70)	0.691
After the Last Injection	37.92±25.66^a	41.25±23.97^a	0.625	62.92±23.63^a	61.04±22.02^a	0.728
After the Last Injection	40 (0-100)	40 (0-100)	0.625	60 (10-100)	60 (20-100)	0.728
1^st month	19.79±18.15^a,b	20.83±17.61^a,b	0.784	79.17±18.57^a,b	76.67±17.8^a,b	0.565
1^st month	20 (0-50)	20 (0-50)	0.784	85 (40-100)	80 (40-100)	0.565
2^nd month	8.75±10.96^a,b,c	12.29±14.37^a,b	0.436	87.71±11.61^a,b	84.38±12.96^a,b	0.382
2^nd month	2.5 (0-40)	10 (0-50)	0.436	90 (60-100)	80 (50-100)	0.382
6^th month	13.33±18.34^a,b	23.33±26.81^a	0.222	85.63±16.24^a,b	74.38±24.11^a	0.072
6^th month	10 (0-60)	10 (0-90)	0.222	90 (50-100)	80 (10-100)	0.072
p*	<0.001	<0.001		<0.001	<0.001

		i-PRF Group	Corticosteroid Group	p1
		Mean±SD	Mean±SD
		Med (Min-Max)	Med (Min-Max)
Thongprasom	Baseline	4.79±0.41	4.71±0.46	0.509
	Baseline	5 (4-5)	5 (4-5)	0.509
	1^st month	1.88±1.3^a	2±1.41^a	0.720
	1^st month	1 (0-5)	2 (0-5)	0.720
	2^nd month	1.58±0.83^a	1.88±1.23^a	0.475
	2^nd month	1 (0-3)	1.5 (0-5)	0.475
	6^th month	1.88±1.08^a	2.21±1.35^a	0.441
	6^th month	1.5 (1-5)	2 (1-5)	0.441
p*		<0.001	<0.001

		Mean±SD
		Med (Min-Max)
OHIP-14	Baseline	34.79±10.85
	Baseline	33 (20-56)
	1^st month	20.04±7.29^a
	1^st month	19.5 (8-41)
	2^nd month	15.83±6.31^a,b
	2^nd month	15 (4-26)
	6^th month	16.42±12.12^a
	6^th month	12 (4-48)
p*		<0.001

Faculdade De Odontologia De Bauru - USP Serviço de Biblioteca e Documentação FOB-USP, Al. Dr. Octávio Pinheiro Brisolla 9-75, 17012-901 Bauru SP Brasil, Tel.: +55 14 32358373 - Bauru - SP - Brazil
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[1] Corresponding address: Ebru Saglam Saglik Bilimleri University - Faculty of Dentistry - Department of Periodontology - Istanbul - Turkey. Phone: +90 212 453 17 00 e-mail: saglam.ebru@yahoo.com