Key Nanotechnology Breakthroughs in Cardiovascular Disease Therapy

It is justified by the high population’s morbidity and mortality rate, as well as the increasing present use of nanoparticles in this pathological context.

Objectives

To describe the main nanotechnology breakthroughs in the field of cardiovascular disease (CVD) and disseminate pertinent information in the literature.

Methods

This is a systematic review conducted between September and October 2021. The review was carried out through basic nature, following the initial script for the selective reading of articles in chronological order to collect relevant and consistent data related to the theme.

Results

It is evidenced the main advances of nanotechnology in the field of CVDs, namely, acute coronary syndromes (ACSs), heart failure (HF), and systemic arterial hypertension (SAH).

Conclusion

The importance of further and deeper studies in this area is emphasized, in order to make the already approved treatments feasible, so they can reach all publics at a low cost.

Nanotechnology; Cardiovascular Diseases; Biomedical Technology

AUTHORS	STUDY/METHOD	NANOPARTICLE STUDIED	STUDY RESULT
Vélez-Reséndiz et al. 2018⁸	In vitro and In vivo	Magnetic nanoparticles of Poly Lactic-co-Glycolic Acid	Modulation of genes involved in the inflammatory process of atherosclerosis
Kamaly et al. 2016¹³	In vitro and Ex vivo	Polymeric nanoparticles Col-IV IL-10 NP22	Prevention of atherosclerotic plaque formation and reduction of necrosis in advanced lesions
Liu et al. 2016¹⁴	Scalable manufacturing method	In₂O₃ nanoribbon	Troponin I uptake below 1 pg/ml in 45 min
Matta et al. 2016¹⁵	Nanomaterial fabrication by chemoresistive detection method	Carbon nanotubes	High sensitivity for detection of troponin, CK-MB and myoglobin at 50 fg/ml
Amezcua et al. 2016¹⁶	Literature review	Electro-wired nanoscaffolding Nanoporous Patches	Regeneration of damaged myocytes and stimulation of contractility in AMI and HF
Baei et al. 2021¹⁷	Laboratory method	Gold nanoparticles embedded in hydrogel scaffolds	Promising proposal for cardiac tissue regeneration
Wang et al. 2016¹⁸	In vivo	Polypyrrole nanoparticles	Improved ejection fraction by 50% and reduced infarct length by 42.6
Mou et al. 2018¹⁹	In vitro	Iron nanoparticles	Increased electrochemical junctions, and decreased structures related to cardiac mechanics
Yu et al. 2017²⁰	Manufacturing method	Collagen hydrogels	Improved cardiomyocyte function
Nair et al. 2017²¹	Heart Tissue Engineering (Manufacturing method)	Gold nanoparticles	Promising in the cardiac myoblast growth and proliferation; low probability of causing cellular toxicity.
Navaei et al. 2017²²	Manufacturing method	Hydrogel GelMA incorporated into GNR	Organization and improvement of cardiac cell function
Sacks et al. 2016²³	Immunoassay sandwich	Nano-Gold Chip	Early identification of HF in hypertensive patients by elevated autoantibodies.

Sociedade Brasileira de Cardiologia Avenida Marechal Câmara, 160, sala: 330, Centro, CEP: 20020-907, (21) 3478-2700 - Rio de Janeiro - RJ - Brazil
E-mail: revistaijcs@cardiol.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Mailing Address: Fernanda Abade Lemos Faculdade Irecê. R. Rio Iguaçu, 397. Postal code: 44990-000. Irecê, BA – Brasil E-mail: fernandalemos222@outlook.com