Sarcopenia and chemotherapy-mediated toxicity

ABSTRACT

This narrative review focuses on the role of sarcopenia and chemotherapy-induced toxicity in cancer patients. Consistent evidence shows that sarcopenia in cancer patients leads to decreased overall survival by influencing treatment discontinuation and dose reduction. Therefore, sarcopenia should be considered a robust prognostic factor of negative outcome as well as a determinant of increased healthcare costs.

Sarcopenia/drug therapy; Muscles/pathology; Neoplasms; Inflammation