ABSTRACT
Objective
This study aimed to verify oral candidiasis, identify the causative species, and investigate the antifungal susceptibility of yeasts isolated from liver transplant patients.
Methods
A descriptive analysis of 97 patients who underwent liver transplantation was conducted at a hospital. Two clinical examinations (Collections A and B) of the oral cavity were performed. Oral material was collected from all patients, inoculated in Sabouraud Dextrose Agar, and incubated at 35℃ for 48 hours. Samples were identified by molecular sequencing of the internal trascribed space region of rDNA.
Results
An antifungal susceptibility test with fluconazole, amphotericin B, and micafungin was performed using the Clinical and Laboratory Standards Institute yeast broth microdilution method. Among the patients, 15 presented with oral candidiasis: eight in Collection A and seven in Collection B. The primary type of candidiasis was atrophic, followed by pseudomembranous candidiasis. The most prevalent species was Candida albicans (nine), followed by Candida glabrata (three), Candida tropicalis (two), and Candida dubliniensis (one). Regarding susceptibility to fluconazole, of the 15 samples, 11 were susceptible, three were susceptible in a dose-dependent manner, and one was resistant.
Conclusion
The most commonly identified type of candidiasis was atrophic, with C. albicans and C. glabrata being the most prevalent causative species. One fluconazole-resistant isolate each of C. tropicalis and C. albicans were identified.
Keywords
Antifungal agents;
Candida
; Candidiasis; Liver transplantation; Candidiasis, oral
In Brief
Sabadin et al. demonstrated that most yeasts isolated from patients who have undergone liver transplantation are susceptible to the antifungal agents fluconazole, amphotericin B, and micafungin. Fifteen patients presented with either atrophic or pseudomembranous oral candidiasis. Candida albicans and Candida glabrata were the most prevalent in these patients
Highlights
Fifteen liver transplant patients presented with oral candidiasis.
The two prevalent types of candidiasis were atrophic and pseudomembranous
Candida albicans and Candida glabrata were the most prevalent species
Most isolates were susceptible to antifungal agents.
