ABSTRACT
Prion diseases are an important cause of rapidly progressive dementias. Among them, the most common is sporadic Creutzfeldt-Jakob disease (CJD). It is a rare and incurable disease, with rapid progression to death.
Objective:
To describe the diagnostic approach of a patient with Creutzfeldt-Jakob disease.
Methods:
The diagnosis is established through the clinical picture associated with characteristic changes in the brain magnetic resonance imaging, the electroencephalogram, and analysis of specific changes in the cerebrospinal fluid.
Results:
The present report describes the case of a 53-year-old patient in the city of Fortaleza-CE. The diagnosis was made based on the clinical condition and through diagnostic tests, including 14-3-3 protein and RT QUIC analysis. Differential diagnosis was performed with other rapidly progressive causes, such as infectious and immune-mediated diseases.
Conclusions:
The diagnosis of probable sporadic CJD was established.
Keywords:
Prion Diseases; Creutzfeldt-Jakob Syndrome; Dementia
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