Excessive amounts of antifungal agent and preservatives were illegally added in an adulterated herbal product for kids

TAN, Daopeng; CUI, Jinguo; SHE, Xiangqian

doi:10.1590/fst.88322

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Food Science and Technology

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Original Article • Food Sci. Technol 42 • 2022 • https://doi.org/10.1590/fst.88322 copy

Excessive amounts of antifungal agent and preservatives were illegally added in an adulterated herbal product for kids

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Illegally manufactured and counterfeit herbal medicines are growing a worldwide issue. And internet sales have simplified the distribution and payment of these counterfeit medicines. In 2019, a paper in The Lancet revealed the tip of the iceberg of counterfeit Chinese herbal medicines in Yongfeng County, Jiangxi Province, China. After 2 years, some so-called Chinese herbal poultices are still being manufactured in these districts. Here we report on a so-called herbal kids creams, which was advertised for treatment of childhood eczema. By means of NMR and HPLC-PDA, we found overdosed antimicrobial agents in the creams, including Terbinafine hydrochloride, Methylparaben, Propylparaben. Hence, compared to glucocorticoids, which are of high concern, the illegal addition of non-hormonal drugs in products for children requires particular attention.

Keywords:
illegal addition; adulterated herbal products; HPLC-PDA; terbinafine hydrochloride; methylparaben; propylparaben

No.	Compound name	Calibration curve^a	R²	Linear range(μg/mL)	LOD^b(μg/mL)	LOQ^c(μg/mL)
1	Methylparaben	y = 37436x + 27325	0.9997	0.76~316.60	0.28	0.76
2	Propylparaben	y = 41868x - 15252	1.0000	0.36~378.00	0.10	0.36
3	Terbinafine hydrochloride	y = 35612x - 37316	0.9998	0.32~487.80	0.10	0.32

No.	Intra-day (RSD, %, n=6)^a			Inter-day (n=6)			Repeatability (n=6)	Stability (n=6, 18h)
No.	low	medium	high	low	medium	high	RSD (%)	RSD (%)
1	1.18	1.05	0.78	1.89	1.61	1.09	1.06	2.38
2	1.31	0.97	0.69	1.37	1.02	0.84	1.13	1.29
3	1.31	1.14	0.68	1.43	1.21	0.91	1.21	2.11

No.	Original (mg)	Spiked (mg)	Found (mg)	Recovery (%)^a	RSD (%)^b
1	1.30	1.04	2.33	99.04 ± 2.91	2.73
	1.32	1.32	2.65	100.76 ± 2.87	2.36
	1.30	1.56	2.84	98.72 ± 3.34	3.03
2	1.56	1.25	2.80	99.20 ± 3.18	2.97
	1.58	1.58	3.17	100.63 ± 2.97	2.21
	1.56	1.87	3.44	100.53 ± 3.45	2.14
3	2.00	1.60	3.58	98.75 ± 2.64	3.04
	2.03	2.03	4.03	98.52 ± 3.22	2.88
	2.00	2.40	4.38	99.17 ± 2.98	2.91

No.	20210406	20210418	20210513	20210528
1	5.27 ± 0.03	6.38 ± 0.04	7.12 ± 0.02	5.33 ± 0.02
2	6.31 ± 0.05	8.23 ± 0.04	6.95 ± 0.02	8.39 ± 0.06
3	8.12 ± 0.03	25.10 ± 0.03	14.36 ± 0.06	21.66 ± 0.04

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[1] *Corresponding author: sxq722000@163.com