The relationship between the insertion/deletion gene polymorphism of ACE and atrial fibrillation in Chinese population: a meta-analysis

ZHU, Yu-xiang; LIU, Gang

doi:10.1590/fst.36020

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Food Science and Technology

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Original Article • Food Sci. Technol (Campinas) 42 • 2022 • https://doi.org/10.1590/fst.36020 copy

The relationship between the insertion/deletion gene polymorphism of ACE and atrial fibrillation in Chinese population: a meta-analysis

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Introduction

In this study, we aimed to explore the relationship between the I/D gene polymorphism of ACE and the risk of AF in Chinese population. Materials and methods: Studies searched in several databases from beginning to July 2019 were included in our study. After screening by evaluation, thirteen articles were selected. Results: Our results showed that I/D gene polymorphism of ACE increased the risk of AF. The stratified analyses by case types and control sources suggested a markedly increased association in lone AF, hypertensive patients with AF, and un-typed AF, as well as in studies with hospital person and healthy person. The stratified geographical analysis indicated the risk of AF increased significantly in North China. Conclusions: All in all, our results indicated the marked relationship between I/D gene polymorphism of ACE and the increased risk of AF in Chinese population.

Keywords:
atrial fibrillation; insertion/deletion; gene polymorphism; angiotensin-converting enzyme

References	Case type	Source of controls	Geographic location	Case number	Control number	Cases			Controls			HWE in control, P-value
References	Case type	Source of controls	Geographic location	Case number	Control number	II	ID	DD	II	ID	DD
Wang et al. (2003)Wang, S., Zhang, P., Chen, F., & Li, F. (2003). Correlation between ACE-I gene polymorphism and atrial fibrillation. Zhongguo Shiyong Neike Zazhi, 23, 537-538.	Lone AF	Healthy subjects	Beijing	53	50	16	26	11	18	24	8	1.000
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Analysis model		n	ORr(95%CI)	ORf(95%CI)	P_h
D vs. I	Total analysis	14	1.29 (1.07-1.55)	1.26 (1.16-1.37)	0.000
	Lone AF	2	1.43 (1.12-1.81)	1.43 (1.12-1.81)	0.585
	Hypertensive patiens with AF	3	1.40 (1.11-1.77)	140 (1.19-1.65)	0.218
	Non-familial structural AF	4	1.00 (0.66-1.52)	0.98 (0.85-1.12)	0.000
	AF	3	1.55 (1.06-2.26)	1.57 (1.30-1.88)	0.018
	Healthy subjects as cotrols	2	1.43 (1.12-1.81)	1.43 (1.12-1.81)	0.585
	Hospitalized patients as controls	11	1.25 (1.00-1.56)	1.23 (1.12-1.34)	0.000
	North China	5	1.51 (1.23-1.87)	1.51 (1.32-1.73)	0.107
	South China	9	1.19 (0.94-1.52)	1.12 (1.01-1.25)	0.000
DD vs. II	Total analysis	14	1.65 (1.17-2.32)	0.99 (0.82-1.19)	0.000
	Lone AF	2	2.26 (1.36-3.75)	2.26 (1.36-3.74)	0.463
	Hypertensive patiens with AF	3	2.20 (1.31-3.71)	2.19 (1.57-3.05)	0.171
	Non-familial structural AF	4	1.00 (0.55-1.81)	0.99 (0.77-1.27)	0.004
	AF	3	2.17 (1.10-4.28)	2.30 (1.60-3.30)	0.037
	Healthy subjects as cotrols	2	2.26 (1.36-3.75)	2.26 (1.36-3.74)	0.463
	Hospitalized patients as controls	11	1.53 (1.02-2.29)	1.49 (1.26-1.77)	0.000
	North China	5	2.24 (1.71-2.92)	2.23 (1.72-2.91)	0.400
	South China	9	1.46 (0.91-2.33)	1.27 (1.03-1.56)	0.000
DD vs. II+ID	Total analysis	14	1.54 (1.20-1.99)	1.55 (1.34-1.78)	0.002
	Lone AF	2	2.04 (1.28-3.24)	2.03 (1.28-3.23)	0.388
	Hypertensive patiens with AF	3	2.25 (1.43-3.53)	2.30 (1.70-3.11)	0.196
	Non-familial structural AF	4	1.10 (0.32-3.51)	1.10 (0.87-1.38)	0.056
	AF	3	1.62 (1.06-2.47)	1.66 (1.22-2.26)	0.176
	Healthy subjects as cotrols	2	2.04 (1.28-3.24)	2.03 (1.28-3.23)	0.388
	Hospitalized patients as controls	11	1.46 (1.08-1.96)	1.48 (1.27-1.73)	0.001
	North China	5	1.96 (1.55-2.47)	1.96 (1.56-2.47)	0.511
	South China	9	1.42 (1.00-2.01)	1.32 (1.10-1.59)	0.003
DD+ID vs. II	Total analysis	14	1.28 (1.00-1.65)	1.19 (1.06-1.35)	0.000
	Lone AF	2	1.39 (0.99-1.96)	1.39 (0.99-1.96)	0.859
	Hypertensive patiens with AF	3	1.21 (0.90-1.63)	1.19 (0.94-1.51)	0.279
	Non-familial structural AF	4	0.93 (0.54-1.62)	0.89 (0.73-1.09)	0.000
	AF	3	1.84 (1.07-3.16)	1.81 (1.37-2.39)	0.026
	Healthy subjects as cotrols	2	1.39 (0.99-1.96)	1.39 (0.99-1.96)	0.859
	Hospitalized patients as controls	11	1.24 (0.92-1.69)	1.15 (1.01-1.32)	0.000
	North China	5	1.54 (1.01-2.35)	1.46 (1.20-1.78)	0.010
	South China	9	1.16 (0.85-1.57)	1.06 (0.91-1.23)	0.001

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[1] *Corresponding author: tjgangiu88@126.com