The recovery effect of Feixingcao tea (Teucrium viscidum Bl.) on inhibiting the decreased exercise ability caused by chronic alcoholic liver injury

Abstract

Feixingcao tea is a health tea, and this study aimed to investigate its improvement in the decreased exercise capacity caused by chronic alcoholic liver injury. A mouse model of chronic liver injury was established by gavage of alcohol, and Feixingcao tea extract (FXCTE) was used to observe the exercise ability, pathological sections and molecular biology methods to detect the effect of FXCTE. And the active ingredient of FXCTE is detected by HPLC. Experimental results showed that FXCTE could increase the time of exhaustive running and negative-gravity swimming in mice with liver injury. FXCTE could reduce alcohol-induced liver lesions. FXCTE could reduce the levels of Lactic acid, BUN, GOT, GPT, TNF-α and iNOS in serum of mice with liver injury. FXCTE could also up-regulate the mRNA expression of Cu/Zn-SOD, Mn-SOD, CAT and down-regulate the expression of nNOS, syncytin-1 in liver injury mice. Component analysis showed that FXCTE contained mangiferin, rutin, ferulic acid, isochlorogenic acid B, astragalin, rosmarinic acid. FXCTE is a health-care tea containing a variety of active compounds, which can improve chronic alcoholic liver damage and improve the decline in exercise ability caused by liver damage.

Keywords:
Feixingcao tea; chronic alcoholic liver injury; exercise ability; oxidation; liver