Abstract
Functional foods have received considerable attention due to their numerous health benefits. Lion's mane mushroom (Hericium erinaceus) is a functional food source that contains bioactive compounds of medicinal importance. The main aim of this study was to explore antimicrobial and anticancer activities and identify bioactive compounds of H. erinaceus mycelia cultivated on mixed red and white jasmine rice (HMR) with the aid of solid-state fermentation (SSF). The HMR extract and its fractions were analyzed for antibacterial activity via disc diffusion and minimum inhibitory concentration (MIC) assays and anticancer activity against cervical cancer (HeLa) examined with the [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] (MTS) assay. Chemical profiles were analyzed using gas chromatography-mass spectrometry (GC-MS). Our results showed that the lipophilic fraction (LF2) had antibacterial activity against P. mirabilis (MIC = 250 µg/mL). LF2 is primarily composed of fatty acid derivatives with antibacterial components, including nonanoic acid, 2-dodecen-1-yl(-) succinic anhydride, linoleic acid ethyl ester, 3,4-dimethylbenzoic acid, and lauryl acetate. However, all HMR fractions displayed relatively weak anticancer activity (IC50 > 100 µg/mL). Our collective findings support the potential utility of H. erinaceus mycelium cultivated on mixed red and white jasmine rice as an antibacterial agent.
Keywords:
Hericium erinaceus; jasmine rice; SSF; lipophilic; bioactivities
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