A medida da amplitude da distribuição do tamanho dos eritrócitos está associada ao risco cardiovascular em adultos

Carvalho, Natane Moreira de; Maluf, Chams Bicalho; Azevedo, Douglas Roberto Mesquita; Reis, Rodrigo Citton Padilha dos; Castilhos, Cristina Dickie de; Barreto, Sandhi Maria; Vidigal, Pedro Guatimosim

Natane Moreira de Carvalho

Departamento de Patologia Clínica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG). Av. Prof. Alfredo Balena 190, Santa Efigênia. 30130-100 Belo Horizonte MG Brasil. natanecarvalho@gmail.com

https://orcid.org/0000-0003-1083-7640

Chams Bicalho Maluf

Departamento de Patologia Clínica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG). Av. Prof. Alfredo Balena 190, Santa Efigênia. 30130-100 Belo Horizonte MG Brasil. natanecarvalho@gmail.com

https://orcid.org/0000-0002-3690-2554

Douglas Roberto Mesquita Azevedo

Departamento de Estatística, UFMG. Belo Horizonte MG Brasil.

https://orcid.org/0000-0001-9741-8662

Rodrigo Citton Padilha dos Reis

Departamento de Estatística, Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre RS Brasil.

https://orcid.org/0000-0003-1766-0964

Cristina Dickie de Castilhos

Departamento de Saúde Pública, UFRGS. Porto Alegre RS Brasil.

https://orcid.org/0000-0001-5986-7942

Sandhi Maria Barreto

Departamento de Saúde Pública, Faculdade de Medicina, UFMG. Belo Horizonte MG Brasil.

https://orcid.org/0000-0001-7383-7811

Pedro Guatimosim Vidigal

Departamento de Patologia Clínica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG). Av. Prof. Alfredo Balena 190, Santa Efigênia. 30130-100 Belo Horizonte MG Brasil. natanecarvalho@gmail.com

https://orcid.org/0000-0001-8035-1350

Collaborations

NM Carvalho, CB Maluf, SM Barreto and PG Vidigal contributed to the conception or design of the work; acquisition, analysis and interpretation of the data; drafted manuscript and critically revised the manuscript. DRM Azevedo contributed to the design of the work; contributed to analysis and interpretation of the data. RCP Reis and CD Castilhos contributed to analysis and interpretation of the data and critically revised the manuscript. All authors gave final approval and agree to be accountable for all aspects of work ensuring integrity and accuracy.

Chief editors:

Romeu Gomes, Antônio Augusto Moura da Silva

Characteristic		RDW quartiles (%)
Characteristic		Q1 11.1-12.69 N=1,362	Q2 12.7-12.99 N=887	Q3 13.0-13.49 N=1,198	Q4 13.5-20.5 N=1,034	p-value
Sex, women		50.44%	53.10%	53.51%	62.09%	<0.001
Age		51.00 [44.00-58.00]	51.00 [45.00-59.00]	52.00 [46.00-58.00]	53.00 [46.00-59.50]	<0.001
Self-rated race/skin color						<0.001
	White	63.73%	62.34%	60.10%	47.49%
	Brown	23.35%	24.01%	23.54%	28.53%
	Black	8.88%	9.24%	13.27%	21.47%
	Other¹	4.04%	4.40%	3.09%	2.51%
Level of education						0.002
	University degree	59.62%	58.62%	58.85%	51.64%
	Incomplete elementary school	3.60%	5.07%	5.26%	6.19%
	Complete elementary school	5.73%	6.76%	6.18%	6.38%
	Complete high school	31.06%	29.54%	29.72%	35.78%
Smoking status						<0.001
	Never smoked	60.35%	56.82%	58.51%	54.64%
	Former smoker	28.71%	32.81%	28.96%	28.53%
	Current smoker	10.94%	10.37%	12.52%	16.83%
Physical activity²						0.457
	Low	74.06%	73.73%	74.37%	75.80%
	Moderate	18.15%	18.94%	17.45%	18.37%
	High	7.79%	7.33%	8.18%	5.83%
Alcohol consumption³, yes		9.18%	8.34%	9.02%	7.93%	0.688
BMI (kg/m²)		25.41 [23.05-28.05]	25.86 [23.44-29.97]	26.23 [23.57-29.41]	27.01 [24.18-30.54]	<0.001
Diabetes mellitus⁴		13.88%	15.14%	14.94%	19.34%	0.002
Hypertension⁵		10.35%	10.48%	10.77%	13.64%	0.050
Hemoglobin (g/dL)		14.30 [13.50-15.40]	14.20 [13.30-15.20]	14.20 [13.30-15.20]	13.70 [12.70-14.70]	<0.001
MCV (fL)		89.40 [87.00-91.80]	88.60 [86.30-90.80]	88.20 [85.50-90.80]	86.70 [82.90-89.70]	<0.001
Total cholesterol (mg/dL)		206.00 [185.00-232.00]	210.00 [183.00-240.00]	212.00 [188.00-240.00]	213.00 [186.00-241.00]	0.005
HDL cholesterol (mg/dL)		53.00 [45.00-63.00]	54.00 [45.20-64.00]	55.00 [46.00-65.00]	56.00 [47.00-67.00]	<0.001
CRP (mg/dL)		1.17 [0.61-2.51]	1.32 [0.70-2.67]	1.46 [0.74-3.20]	2.05 [0.91-4.31]	<0.001
eGFR⁶>60 mL/min		96.55%	95.71%	95.16%	95.16%	0.267

Model	FRS				R²Aj
	Q1 11.1-12.69 N=1,362	Q2 12.7-12.99 N=887	Q3 13.0-13.49 N=1,198	Q4 13.5-20.5 N=1,034
	e^β; p-value [95%CI]	e^β; p-value [95%CI]	e^β; p-value [95%CI]	e^β; p-value [95%CI]
1¹	Reference	1.062; 0.079 [0.993-1.136]	1.083; 0.011 [1.018-1.153]	1.290; ≤0,001 [1.206-1.380]	0.299
2²	Reference	1.060; 0.088 [0.991-1.134]	1.087; 0.008 [1.021-1.153]	1.299; ≤0.001 [1.215-1.390]	0.298

Model	FRS
	Q1 11.1-12.69 N=1,274	Q2 12.7-12.99 N=818	Q3 13.0-13.49 N=1,112	Q4 13.5-20.5 N=947
	e^β; p-value [95%CI]	e^β; p-value [95%CI]	e^β; p-value [95%CI]	e^β; p-value [95%CI]
1¹	Reference	1.051; 0.122 [0.986-1.121]	1.083; 0.007 [1.021-1.149]	1.280; ≤0.001 [1.201-1.364]
2²	Reference	1.062; 0.070 [0.994-1.134]	1.085; 0.008 [1.021-1.153]	1.290; ≤0.001 [1.208-1.377]
2²	Interaction terms time	(p-value) 0.236	(p-value) 0.455	(p-value) 0.057

[1] Collaborations

NM Carvalho, CB Maluf, SM Barreto and PG Vidigal contributed to the conception or design of the work; acquisition, analysis and interpretation of the data; drafted manuscript and critically revised the manuscript. DRM Azevedo contributed to the design of the work; contributed to analysis and interpretation of the data. RCP Reis and CD Castilhos contributed to analysis and interpretation of the data and critically revised the manuscript. All authors gave final approval and agree to be accountable for all aspects of work ensuring integrity and accuracy.

Brasil

Brasil

A medida da amplitude da distribuição do tamanho dos eritrócitos está associada ao risco cardiovascular em adultos

Resumo