Reference |
Species |
Cancer |
Main results |
MARQUARD et al., 2008MARQUARD, L. et al. Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T‐cell lymphoma. Histopathology, v.53, n.3, p.267-277, 2008. Available from: <Available from: https://doi.org/10.1111/j.1365-2559.2008.03109.x >. Accessed: Aug. 02, 2022. doi: 10.1111/j.1365-2559.2008.03109.x. https://doi.org/10.1111/j.1365-2559.2008...
|
Human |
Cutaneous lymphoma |
High expression of HDAC2. |
ELSHEIKH et al. 2009ELSHEIKH, S. E. et al. Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome. Cancer research, v.69, n.9, p.3802-3809, 2009. Available from: <Available from: https://doi.org/10.1158/0008-5472.CAN-08-3907 >. Accessed: Sep. 10, 2022. doi: 10.1158/0008-5472.CAN-08-3907. https://doi.org/10.1158/0008-5472.CAN-08...
|
Human |
Breast cancer |
Low levels of acetylation of H4K16Ac. High levels of acetylation of H3K18Ac. |
SUZUKI et al., 2009SUZUKI, J. et al. Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression. Clinical Cancer Research, v.15, n.9, p.3163-3171, 2009. Available from: <Available from: https://doi.org/10.1158/1078-0432.CCR-08-2319 >. Accessed: Sep. 12, 2022. doi: 10.1158/1078-0432.CCR-08-2319. https://doi.org/10.1158/1078-0432.CCR-08...
|
Human |
Breast cancer |
Hypoacetylation of H4Ac and H4K12Ac in carcinomas in situ and invasive carcinomas. |
KRUSCHE et al., 2005KRUSCHE, C. A. et al. Histone deacetylase-1 and-3 protein expression in human breast cancer: a tissue microarray analysis. Breast cancer research and treatment, v.90, p.15-23, 2005. Available from: <Available from: https://doi.org/10.1007/s10549-004-1668-2 >. Accessed: Aug. 02, 2022. doi: 10.1007/s10549-004-1668-2. https://doi.org/10.1007/s10549-004-1668-...
|
Human |
Breast cancer |
High HDAC1 expressions correlate with smaller tumors and longer survival time. |
MULLER et al., 2013MÜLLER, B. M. et al. Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer-overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression. BMC cancer, v.13, n.1, p.1-8, 2013. Available from: <Available from: https://doi.org/10.1186/1471-2407-13-215 >. Accessed: Aug. 10, 2022. doi: 10.1186/1471-2407-13-215. https://doi.org/10.1186/1471-2407-13-215...
|
Human |
Breast cancer |
High expression of HDAC2 and HDAC3 in more aggressive tumors and patients who had shorter survival times. |
TOH et al., 2004TOH, Y. et al. Expression of the metastasis‐associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas. International Journal of Cancer, v.110, n.3, p.362-367, 2004. Available from: <Available from: https://doi.org/10.1002/ijc.20154 >. Accessed: Sep. 12, 2022. doi: 10.1002/ijc.20154. https://doi.org/10.1002/ijc.20154...
|
Human |
Esophageal squamous cell carcinomas |
Hypoacetylation of histone H4Ac correlated with neoplasms in the advanced evolution stage and an increase in acetylation with a better prognosis. |
FUJIWARA-IGARASHI et al., 2016FUJIWARA-IGARASHI, A. et al. Regulation of p16 gene expression by histone H3 acetylation in canine lymphoid tumor cell lines. Japanese Journal of Veterinary Research, v.64, n.4, p.257-263, 2016. Available from: <Available from: https://doi.org/10.14943/jjvr.64.4.257 >. Accessed: Sep. 02, 2022. doi: 10.14943/jjvr.64.4.257. https://doi.org/10.14943/jjvr.64.4.257...
|
Canine |
Immunophenotype B canine lymphoma cell lines |
Low acetylation of H3 correlated with low expression of P16 mRNA. |
ETO et al., 2019ETO, S. et al. Anti-tumor effects of the histone deacetylase inhibitor vorinostat on canine urothelial carcinoma cells. PLoS One, v.14, n.6, p.e0218382, 2019. Available from: <Available from: https://doi.org/10.1371/journal.pone.0218382 >. Accessed: Sep. 01, 2022. doi: 10.1371/journal.pone.0218382. https://doi.org/10.1371/journal.pone.021...
|
Canine |
Urothelial carcinomas |
Low expression of H3K9Ac in urothelial carcinomas and correlation with poor prognosis. |
SIERRA, 2019 |
Canine |
Cutaneous lymphoma |
Hypoacetylation of H3K9 and aberrant expression of H4K12Ac associated with HDAC2 related to shorter survival times. |
SENHORELLO, 2020SENHORELLO, I. L. S. Avaliação do padrão de acetilação das histonas H3 e H4 e expressão das enzimas HDAC1, HDAC2 e HDAC6 em tumores mamários de cadelas. 2020. Available from: <Available from: https://repositorio.unesp.br/handle/11449/194509 >. Accessed: Jan. 12, 2022. https://repositorio.unesp.br/handle/1144...
|
Canine |
Mammary tumors |
Lower acetylation of H3K9Ac in breast carcinomas, expression of HDAC1 and HDCA2 lower in neoplastic breast tissues and HDAC6 more expressed in neoplastic breast tissues. |
SENA et al., 2022SENA, B. V. et al. Immunolabelling of Acetylated Histones 3 and 4 and Histone Deacetylases 1, 2 and 6 in Canine Soft Tissue Sarcomas. Journal of Comparative Pathology, v.193, p.51-58, 2022. Available from: <Available from: https://doi.org/10.1016/j.jcpa.2022.03.001 >. Accessed: Sep. 12, 2022. doi: 10.1016/j.jcpa.2022.03.001. https://doi.org/10.1016/j.jcpa.2022.03.0...
|
Canine |
Soft tissue sarcomas |
High correlation between the expression of H3K9Ac and the number of mitotic figures and intense immunolabelling of HDAC1. |