To analyse the circadian variations of the leucocyte, fibrinogen and platelet 20 mongrel male dogs were used divided into two groups of ten animals. The first group was exposed to an inflamatory process induced by the administration of turpentine and after 24 hours the animals were treated with Aesein 1.3mg/kg from 12 to 12 hours. The second group was only exposed to the inflamatory process. Blood samples were performed in all the animals at 0,4am, 8am, 12am, 4pm, 8pm and 12pm hours of the day to examine the parameters. Aescin has determined monocytose at 0,8am, 12am, 4pm and 12pm; linfopenia at 4pm and 12pm; leucocitosis at 0,8pm and 12 pm, as well as an increase in the amount of fibrinogen at 4pm and 12pm; and a decrease in the platelets during all day. Aescin determines unstable circadian variations in the number of leucocyte, platelet and in the amount of fibrinogen in dogs with inflamatory process.
aescin; circadian variation; leucocyte; fibrinogen; platelet; inflamatory process; dogs
