1 |
Schulz et al. (2004) (1010. Schulz JA, Nager CW, Stanton SL, Baessler K. Bulking agents for stress urinary incontinence: short-term results and complications in a randomized comparison of periurethral and transurethral injections. Int Urogynecol J Pelvic Floor Dysfunct. 2004;15(4):261-65, 10.1007/s00192-004-1148-6. http://dx.doi.org/10.1007/s00192-004-114...
) |
Periurethral injection with dextran copolymer (20) |
Transurethral injection with dextran copolymer (20) |
SUI (n=36)MUI (n=4) |
Patients dry only if they had 100% improvement and no leakage episodes |
Subjective mean improvement |
1, 3, 6 and 12 months |
Urinary retention |
MUCP <20 cmH2O and a VLPP <60 cmH2O |
2 |
Kuhn et al. (2008) (1111. Kuhn A, Stadlmayr W, Lengsfeld D, Mueller MD. Where should bulking agents for female urodynamic stress incontinence be injected? Int Urogynecol J Pelvic Floor Dysfunct. 2008;19(6):817-21, 10.1007/s00192-007-0535-1. http://dx.doi.org/10.1007/s00192-007-053...
) |
Midurethral injection with collagen TI (15) |
Bladder neck injection with collagen TI (15) |
SUI (n=30) |
Patient satisfaction (VAS) |
Cough test, urethral resting pressure, functional urethral length |
6 weeks and 10 months |
Residual urine (US) |
NM |
3 |
Bano et al. (2005) (1212. Bano F, Barrington JW, Dyer R. Comparison between porcine dermal implant (Permacol) and silicone injection (Macroplastique) for urodynamic stress incontinence. Int Urogynecol J Pelvic Floor Dysfunct. 2005;16(2):147-50; discussion 150, 10.1007/s00192-004-1216-y. http://dx.doi.org/10.1007/s00192-004-121...
) |
Silicone TI (24) |
Porcine dermal implant (27) [TI (13)+ PI (14)] |
SUI (n=50) |
Pad test |
Stamey, KCQ |
6 weeks and6 months |
Urinary retention, urge incontinence |
NM |
4 |
Ghoniem et al. (2009) (1313. Ghoniem G, Corcos J, Comiter C, Bernhard P, Westney OL, Herschorn S. Cross-linked polydimethylsiloxane injection for female stress urinary incontinence: results of a multicenter, randomized, controlled, single-blind study. J Urol. 2009;181(1):204-10, 10.1016/j.juro.2008.09.032. http://dx.doi.org/10.1016/j.juro.2008.09...
) |
Silicone TI (122) |
Collagen TI (125) |
SUI with ISD (n=247) |
Stamey |
I-QOL, pad test |
1, 3, 6 and 12 months |
Genitourinary adverse effects |
NM |
5 |
Meulen et al. (2009) (1414. ter Meulen PH, Berghmans LC, Nieman FH, van Kerrebroeck PE. Effects of Macroplastique Implantation System for stress urinary incontinence and urethral hypermobility in women. Int Urogynecol J Pelvic Floor Dysfunct. 2009;20(2):177-83, 10.1007/s00192-008-0741-5. http://dx.doi.org/10.1007/s00192-008-074...
) |
Silicone TI (24) |
Pelvic floor muscle exercises (21) |
SUI with urethral hypermobility (n=45) |
Pad test Stamey |
Patient global impression, I-QOL |
3 and 12 months |
Genitourinary adverse effects, leakage implant |
NA |
6 |
Lee et al. (2001) (1515. Lee PE, Kung RC, Drutz HP. Periurethral autologous fat injection as treatment for female stress urinary incontinence: a randomized double-blind controlled trial. J Urol. 2001;165(1):153-8, 10.1097/00005392-200101000-00037. http://dx.doi.org/10.1097/00005392-20010...
) |
Autologous fat PI (35) |
Placebo PI (33) |
SUI (n=68) |
Pad test |
UIQ, MUCP, LPP |
1, 2, 3, 6, 9, 12, 18 and 24 months |
UTI, liposuction site infection, urinary retention, fat embolism |
NM |
7 |
Corcos et al. (2005) (77. Corcos J, Collet JP, Shapiro S, Herschorn S, Radomski SB, Schick E, et al. Multicenter randomized clinical trial comparing surgery and collagen injections for treatment of female stress urinary incontinence. Urology. 2005;65(5):898-904, 10.1016/j.urology.2004.11.054. http://dx.doi.org/10.1016/j.urology.2004...
) |
Collagen TI (64) |
Urinary incontinence surgery (54) |
MUI or SUI (n=133) |
Pad test |
Symptoms of incontinence, general QOL, disease-specific QOL, and depression |
1, 3, 6 and 12 months |
Urinary retention, transient hematuria, urinary infection, voiding difficulty |
NA |
8 |
Lightner et al. (2001) (44. Lightner D, Calvosa C, Andersen R, Klimberg I, Brito CG, Snyder J, et al. A new injectable bulking agent for treatment of stress urinary incontinence: results of a multicenter, randomized, controlled, double-blind study of Durasphere. Urology. 2001;58(1):12-5, 10.1016/S0090-4295(01)01148-7. http://dx.doi.org/10.1016/S0090-4295(01)...
) |
Pyrolytic carbon TI (178) |
Collagen TI (177) |
SUI with ISD (n=355) |
Pad test Stamey |
Adverse effects |
1, 3, 6 and 12 months |
Urinary retention, urgency |
History and VLPP <90 cmH2O |
9 |
Lightner et al. (2009) (1616. Lightner D, Rovner E, Corcos J, Payne C, Brubaker L, Drutz H, et al. Randomized controlled multisite trial of injected bulking agents for women with intrinsic sphincter deficiency: mid-urethral injection of Zuidex via the Implacer versus proximal urethral injection of Contigen cystoscopically. Urology. 2009;74(4):771-5, 10.1016/j.urology.2009.05.034. http://dx.doi.org/10.1016/j.urology.2009...
) |
Dextran polymer (143) |
Collagen (88) |
SUI (n=344) |
The proportion of women who achieved a ≥50% reduction in urinary leakage on provocation testing performed at baseline presentation com- pared with that at 12 months after the last treatment |
Stamey, pad test, voiding diary, I-QOL |
1, 2, 3, 6 and 12 months |
Urinary retention, urgency, Urinary infection, pain |
VLPP <100 cmH2O |
10 |
Mayer et al. (2007) (1717. Mayer RD, Dmochowski RR, Appell RA, Sand PK, Klimberg IW, Jacoby K, et al. Multicenter prospective randomized 52-week trial of calcium hydroxylapatite versus bovine dermal collagen for treatment of stress urinary incontinence. Urology. 2007;69(5):876-80, 10.1016/j.urology.2007.01.050. http://dx.doi.org/10.1016/j.urology.2007...
) |
Calcium hydroxyapatite (158) [TI (145)+ PI (13)] |
Collagen (138) [TI (123)+ PI (15)] |
SUI with ISD (n=296) |
Stamey |
QOL, pad test |
12 months |
NM |
NM |
11 |
Anders et al. (1999) (1818. Anders K, Khullar V, Cardozo L, Bidmead J, Athanasiou S, Hobson P. Gax collagen or macroplastique, does it make a difference? (Abstract). Neurourology & Urodynamics. 1999;18(4):297-8.) |
Silicone (34) |
Collagen (26) |
SUI with ISD (n=60) |
Patient satisfaction, KCQ |
Symptoms of incontinence, frequency, urgency, pad test |
60 months |
NM |
NM |
12 |
Andersen (2002) (1919. Andersen RC. Long-term follow-up comparison of durasphere and contigen in the treatment of stress urinary incontinence. J Low Genit Tract Dis. 2002;6(4):239-43.) |
Pyrolytic carbon (26) |
Collagen (26) |
SUI with ISD (n=52) |
Stamey |
Pad test |
2.6 and 2.8 years |
NM |
VLPP <90 cmH2O |
13 |
Maher et al. (2005) (2020. Pannek J, Brands FH, Senge T. Particle migration after transurethral injection of carbon coated beads for stress urinary incontinence. J Urol. 2001;166(4):1350-3, 10.1016/S0022-5347(05)65767-9. http://dx.doi.org/10.1016/S0022-5347(05)...
) |
Silicone TI (23) |
Pubovaginal sling (22) |
SUI with ISD (n=45) |
Success rates, complications, costs |
SUDI, IIQ, pad test |
6 weeks and 6, 12, and 60 months |
Frequency, nocturia, urgency, urge incontinence, stress incontinence, voiding difficulty |
MUCP <20 cmH2O |
14 |
Sokol et al. (2014) (2727. Sokol ER, Karram MM, Dmochowski R. Efficacy and safety of polyacrylamide hydrogel for the treatment of female stress incontinence: a randomized, prospective, multicenter North American study. J Urol. 2014;192(3):843-9, 10.1016/j.juro.2014.03.109. http://dx.doi.org/10.1016/j.juro.2014.03...
) |
Polyacrylamide hydrogel (229) |
Collagen (116) |
SUI or stress-predominant mixed UI |
The proportion of women at the 12-month follow-up with a ≥50% decrease from baseline in leakage, as measured by the 24-hour pad test, and a ≥50% decrease from baseline in the self-reported daily number of incontinence episodes |
The proportion of women dry (4 gm or less) or improved according to the 24-hour pad test, ICIQ-UI, patient diary, responder rate, I-QOL |
1, 3, 6, 9 and 12 months |
Urinary retention, de novo urge incontinence, dysuria, excreted bulking material, hematuria, nocturia non-acute urinary pain,urinary tract infection |
VLPP <100 cmH2O |