Study of aged central auditory function using the auditory middle latency response

De Oliveira, Anna Caroline Silva; Alcântara, Yara Bagali; De Góes, Viviane Borim; Menezes, Pedro de Lemos; Chagas, Eduardo Federighi Baisi; Machado, Milena Sonsini; Frizzo, Ana Claudia Figueiredo

doi:10.1016/j.clinsp.2023.100245

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Sumário

Original articles • Clinics 78 • 2023 • https://doi.org/10.1016/j.clinsp.2023.100245 copy

Study of aged central auditory function using the auditory middle latency response

Authorship SCIMAGO INSTITUTIONS RANKINGS

Highlights

Aging impairs binaural interaction in cortical and subcortical regions, elderly people with hearing loss show differences in responses between the ears/electrodes.
Elderly people without hearing loss show differences in responses between the hemispheres.
Binaural interaction is more impaired in older adults with high-frequency hearing loss.

Abstract

Objective

Investigate the auditory function of the elderly using the middle latency potentials.

Methodology

Group 1 (G1): 20 healthy individuals of both genders, older than 60 years, without hearing loss. Group 2 (G2): 20 healthy individuals of both sexes, older than 60 years, with hearing loss in frequencies from 4 to 8 kHz. Potential recording was performed with unilateral and bilateral stimulation and the Binaural Interaction Component was calculated.

Results

Na latency in C3A1 was greater in the stimulation of the right ear in G2 and the amplitude of Na-Pa was greater in the stimulation of the right ear and recording in C3A1 in G1. The latency of the Pa component was higher in the stimulation of the right ear recorded in C4A2. The Pb component in G2 by bilateral stimulation and recorded in C4A2 had higher latency. The first and second negative and positive peaks presented greater amplitude in G1. In C3A1, the 1^st negative peak was more negative in G1 and the 2^nd positive peak showed greater amplitude in C4A2 in both groups.

Conclusion

The transmission of auditory information to the primary auditory cortex is impaired with aging, especially in unilateral stimulation, reinforced by losses in elderly people with peripheral hearing loss, such as in the binaural interaction at the cortical and subcortical levels. Thus, the AMLR has shown to be a sensitive examination to investigate neuroauditory disorders in the elderly, especially related to high-frequency hearing loss and primary auditory cortex dysfunctions caused by the aging process.

Keywords
Auditory evoked potentials; Acoustic stimulation; Aged; Auditory cortex

	Group				Ancova
	G1 (n = 20)		G2 (n = 20)		p	P	p
Condition	Mean	SD	Mean	SD	Group	Condition	Interaction
RE_C4A2Ipsi_LatNa	18.5	3.9	19.7	3.6	0.970	0.823	0.154
LE_C4A2Contra_LatNa	20.6	4.4	19.3	2.5
Bi_C4A2_LatNa	19.6	4.7	19.8	3.6
RE_C3A1Contra_LatNa	19.6	3.4	22.7^a,b	3.0	0.067	0.020**	0.108
LE_C3A1Ipsi_LatNa	18.2	5.1	19.3^a	3.0
Bi_C3A1_LatNa	19.3	3.8	19.0^b	3.2
RE_C4A2Ipsi_LatPa	31.6	4.4	30.3	3.8	0.437	0.873	0.924
LE_C4A2Contra_LatPa	31.8	4.0	30.9	4.3
Bi_C4A2_LatPa	32.3	4.9	31.4	4.7
RE_C3A1Contra_LatPa	29.6	3.1	32.0	4.4	0.576	0.472	0.081
LE_C3A1Ipsi_LatPa	31.0	4.5	31.1	4.6
Bi_C3A1_LatPa	31.4	4.7	30.1	4.5
RE_C4A2Ipsi_LatNb	45.0	5.0	45.4	4.4	0.831	0.356	0.763
LE_C4A2Contra_LatNb	47.8	5.1	46.0	11.1
Bi_C4A2_LatNb	49.2	5.7	49.7	4.3
RE_C3A1Contra_LatNb	47.2	6.7	45.9	5.9	0.719	0.214	0.348
LE_C3A1Ipsi_LatNb	46.7	6.2	48.2	5.5
Bi_C3A1_LatNb	50.1	5.4	49.5	3.9
RE_C4A2Ipsi_LatPb	51.8	18.0	53.5	18.6	0.680	0.442	0.962
LE_C4A2Contra_LatPb	43.3	25.8	47.8	24.8
Bi_C4A2_LatPb	42.5	28.8	46.3	27.6
RE_C3A1Contra_LatPb	41.1	27.7	46.8	24.4	0.230	0.169	0.428
LE_C3A1Ipsi_LatPb	43.5	26.2	57.9	14.3
Bi_C3A1_LatPb	42.5	28.8	45.8	27.5
RE_C4A2Ipsi_AmpNaPa	-0.90	0.59	-0.65	0.57	0.471	0.070	0.695
LE_C4A2Contra_AmpNaPa	-1.04	0.68	-0.91	0.81
Bi_C4A2_AmpNaPa	-1.21	0.68	-1.06	0.78
RE_C3A1Contra_AmpNaPa	-1.21^a	0.68	-0.73^a	0.54	0.156	0.195	0.038*
LE_C3A1Ipsi_AmpNaPa	-0.97	0.56	-0.99	0.83
Bi_C3A1_AmpNaPa	-1.19	0.58	-0.82	0.48

	Group				Ancova
	G1 (n = 20)		G2 (n = 20)		P	p	p
Condition	Mean	SD	Mean	SD	Group	Condition	Interaction
RE_C4A2Ipsi_LatNa	18.45	3.87	19.68	3.63	0.019*	0.986	0.232
RE_C3A1Contra_LatNa	19.64^a	3.38	22.73^a	2.96
LE_C3A1Ipsi_LatNa	18.18^a	5.13	19.30	2.95	0.885	0.012*	0.017**
LE_C4A2Contra_LatNa	20.64^a	4.43	19.25	2.45
Bi_C3A1_LatNa	19.25	3.80	18.98	3.24	0.999	0.361	0.592
Bi_C4A2_LatNa	19.62	4.70	19.82	3.59
RE_C4A2Ipsi_LatPa	31.62^a	4.44	30.33	3.80	0.561	0.601	0.013*
RE_C3A1Contra_LatPa	29.61^a	3.08	32.00	4.40
LE_C3A1Ipsi_LatPa	30.95	4.47	31.13	4.56	0.933	0.768	0.581
LE_C4A2Contra_LatPa	31.75	3.99	30.92	4.26
Bi_C3A1_LatPa	31.42	4.71	30.07	4.48	0.509	0.606	0.851
Bi_C4A2_LatPa	32.25	4.95	31.36	4.68
RE_C4A2Ipsi_LatNb	45.01	5.01	45.45	4.42	0.752	0.216	0.196
RE_C3A1Contra_LatNb	47.17	6.74	45.93	5.94
LE_C3A1Ipsi_LatNb	46.73	6.20	48.18	5.53	0.942	0.475	0.320
LE_C4A2Contra_LatNb	47.78	5.09	45.96	11.06
Bi_C3A1_LatNb	50.06	5.42	49.49	3.89	0.635	0.178	0.388
Bi_C4A2_LatNb	49.25	5.67	49.70	4.25
RE_C4A2Ipsi_LatPb	51.79	17.98	53.49	18.63	0.563	0.475	0.714
RE_C3A1Contra_LatPb	41.14	27.74	46.79	24.39
LE_C3A1Ipsi_LatPb	43.53	26.15	57.89	14.26	0.127	0.113	0.150
LE_C4A2Contra_LatPb	43.33	25.79	47.76	24.78
Bi_C3A1_LatPb	42.49	28.76	45.78^a	27.45	0.679	0.014**	0.725
Bi_C4A2_LatPb	42.54	28.84	46.33^a	27.63
RE_C4A2Ipsi_AmpNaPa	-0.90	0.59	-0.65	0.57	0.047*	0.209	0.184
RE_C3A1Contra_AmpNaPa	-1.21^a	0.68	-0.73^a	0.54
LE_C3A1Ipsi_AmpNaPa	-0.97	0.56	-0.99	0.83	0.978	0.318	0.570
LE_C4A2Contra_AmpNaPa	-1.04	0.68	-0.91	0.81
Bi_C3A1_AmpNaPa	-1.19	0.58	-0.82	0.48	0.270	0.804	0.250
Bi_C4A2_AmpNaPa	-1.21	0.68	-1.06	0.78

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[1] * Corresponding author. E-mail address:Ana.frizzo@unesp.br (A.C.F. Frizzo).