Methyl-CpG binding protein 2 is associated with the prognosis and mortality of elderly patients with hip fractures

Highlights

• MECP2 was downregulated in elderly patients with hip fracture.

• MECP2 was correlated with inflammatory factors in hip fractures.

• Lower MECP2 predicted poor clinical outcomes of hip fractures.

• Lower MECP2 predicted higher mortality and postoperative complications.

ABSTRACT

Objectives

To investigate the expression level and clinical significance of Methyl-CpG binding Protein 2 (MECP2) in elderly patients with hip fractures.

Methods

This prospective observational study included 367 elderly patients with hip fractures between April 2016 and December 2018. All the patients were treated with internal fixation or joint replacement. In addition, 50 healthy elderly individuals were enrolled as healthy controls. The serum levels of MECP2 and inflammatory factors Interleukin (IL)-1β, IL-6, IL-8, and Tumor Necrosis Factor (TNF)-α was determined by enzyme-linked immunosorbent assay. Data on patients' basic characteristics and postoperative complications were collected. The Harris score was used to assess hip function at 1-month, 3-months, and 6-months after surgery. Patient quality of life was measured using the Barthel Index (BI) score 3-months after surgery. The 1-year mortality was analyzed using the Kaplan-Meier curve, and logical regression was used to analyze the risk factors for mortality.

Results

No significant differences were observed in the basic clinical characteristics of all patients. The serum MECP2 levels were remarkably high in patients with hip fractures and negatively correlated with serum IL-1β, IL-6, and TNF-α levels. Patients with higher MECP2 predicted higher dynamic Harris scores, lower postoperative complications, lower 1-year mortality, and higher BI scores. Logical regression showed that age was the only independent risk factor for postoperative 1-year mortality in elderly patients with hip fractures.

Conclusion

Lower MECP2 predicted poor prognosis and higher 1-year mortality in elderly patients with hip fractures.

Keywords
MECP2; Prognosis; Hip fracture