Del Real et al. (1111. Del Real RP, Ooms E, Wolke JG, Vallet-Regi M, Jansen JA. In vivo bone response to porous calcium phosphate cement. J Biomed Mater Res A. 2003;65(1):30-6, http://dx.doi.org/10.1002/jbm.a.10432. http://dx.doi.org/10.1002/jbm.a.10432...
) |
Goat |
Metaphysis |
6.3 |
10 |
CP |
- |
100 |
47.0 |
HMM |
0.0 |
Del Real et al., 2002 |
Goat |
Metaphysis |
6.3 |
10 |
CP |
- |
100 |
59.0 |
HMM |
20.0 |
Hing et al. (1212. Hing KA, Best SM, Tanner KE, Bonfield W, Revell PA. Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes. J Biomed Mater Res A. 2004;68(1):187-200, http://dx.doi.org/10.1002/jbm.a.10050. http://dx.doi.org/10.1002/jbm.a.10050...
) |
Rabbit |
Metaphysis |
4.5 |
26 |
HA |
- |
350 |
60.0 |
HMM |
28.0 |
Hasegawa et al. (1313. Hasegawa S, Tamura J, Neo M, Goto K, Shikinami Y, Saito M, et al. In vivo evaluation of a porous hydroxyapatite/poly-DL-lactide composite for use as a bone substitute. J Biomed Mater Res A. 2005;75(3):567-79, http://dx.doi.org/10.1002/jbm.a.30460. http://dx.doi.org/10.1002/jbm.a.30460...
) |
Rabbit |
Metaphysis |
6.0 |
26 |
HA |
- |
480 |
70.0 |
HMM |
27.0 |
Hasegawa et al. (1313. Hasegawa S, Tamura J, Neo M, Goto K, Shikinami Y, Saito M, et al. In vivo evaluation of a porous hydroxyapatite/poly-DL-lactide composite for use as a bone substitute. J Biomed Mater Res A. 2005;75(3):567-79, http://dx.doi.org/10.1002/jbm.a.30460. http://dx.doi.org/10.1002/jbm.a.30460...
) |
Rabbit |
Metaphysis |
6.0 |
26 |
HA |
- |
200 |
70.0 |
HMM |
23.0 |
von Doernberg et al. (1414. von Doernberg MC, von Rechenberg B, Bohner M, Grünenfelder S, van Lenthe GH, Müller R, et al. In vivo behavior of calcium phosphate scaffolds with four different pore sizes. Biomaterials. 2006;27(30):5186-98, http://dx.doi.org/10.1016/j.biomaterials.2006.05.051. http://dx.doi.org/10.1016/j.biomaterials...
) |
Goat |
Metaphysis |
8.0 |
24 |
CP |
- |
150 |
75.0 |
HMM |
22.0 |
von Doernberg et al. (1414. von Doernberg MC, von Rechenberg B, Bohner M, Grünenfelder S, van Lenthe GH, Müller R, et al. In vivo behavior of calcium phosphate scaffolds with four different pore sizes. Biomaterials. 2006;27(30):5186-98, http://dx.doi.org/10.1016/j.biomaterials.2006.05.051. http://dx.doi.org/10.1016/j.biomaterials...
) |
Goat |
Metaphysis |
8.0 |
24 |
CP |
- |
260 |
75.0 |
HMM |
37.0 |
von Doernberg et al. (1414. von Doernberg MC, von Rechenberg B, Bohner M, Grünenfelder S, van Lenthe GH, Müller R, et al. In vivo behavior of calcium phosphate scaffolds with four different pore sizes. Biomaterials. 2006;27(30):5186-98, http://dx.doi.org/10.1016/j.biomaterials.2006.05.051. http://dx.doi.org/10.1016/j.biomaterials...
) |
Goat |
Metaphysis |
8.0 |
24 |
CP |
- |
510 |
75.0 |
HMM |
25.0 |
von Doernberg et al. (1414. von Doernberg MC, von Rechenberg B, Bohner M, Grünenfelder S, van Lenthe GH, Müller R, et al. In vivo behavior of calcium phosphate scaffolds with four different pore sizes. Biomaterials. 2006;27(30):5186-98, http://dx.doi.org/10.1016/j.biomaterials.2006.05.051. http://dx.doi.org/10.1016/j.biomaterials...
) |
Goat |
Metaphysis |
8.0 |
24 |
CP |
- |
1220 |
75.0 |
HMM |
20.0 |
Kroese-Deutman et al. (1515. Kroese-Deutman HC, Ruhé PQ, Spauwen PHM, Jansen JA. Bone inductive properties of rhBMP-2 loaded porous calcium phosphate cement implants inserted at an ectopic site in rabbits. Biomaterials. 2005;26(10):1131-8, http://dx.doi.org/10.1016/j.biomaterials.2004.04.021. http://dx.doi.org/10.1016/j.biomaterials...
) |
Rabbit |
Calvaria |
6.0 |
12 |
CP |
- |
150 |
71.0 |
HMM |
17.0 |
Kroese-Deutman et al. (1515. Kroese-Deutman HC, Ruhé PQ, Spauwen PHM, Jansen JA. Bone inductive properties of rhBMP-2 loaded porous calcium phosphate cement implants inserted at an ectopic site in rabbits. Biomaterials. 2005;26(10):1131-8, http://dx.doi.org/10.1016/j.biomaterials.2004.04.021. http://dx.doi.org/10.1016/j.biomaterials...
) |
Rabbit |
Calvaria |
9.0 |
12 |
CP |
- |
150 |
74.0 |
HMM |
18.0 |
Xu et al. (1616. Xu HHK, Quinn JB. Calcium phosphate cement containing resorbable fibers for short-term reinforcement and macroporosity. Biomaterials. 2002;23(1):193-202, http://dx.doi.org/10.1016/S0142-9612(01)00095-3. http://dx.doi.org/10.1016/S0142-9612(01)...
) |
Rabbit |
Calvaria |
10.0 |
16 |
CS |
- |
400 |
74.9 |
HMM |
28.4 |
Xu et al. (1616. Xu HHK, Quinn JB. Calcium phosphate cement containing resorbable fibers for short-term reinforcement and macroporosity. Biomaterials. 2002;23(1):193-202, http://dx.doi.org/10.1016/S0142-9612(01)00095-3. http://dx.doi.org/10.1016/S0142-9612(01)...
) |
Rabbit |
Calvaria |
10.0 |
16 |
CP |
- |
400 |
72.3 |
HMM |
18.8 |
Tang et al. (33. Tang PF, Li G, Wang JF, Zheng QJ, Wang Y. Development, characterization, and validation of porous carbonated hydroxyapatite bone cement. J Biomed Mater Res B Appl Biomater. 2009;90(2):886-93, http://dx.doi.org/10.1002/jbm.b.31360. http://dx.doi.org/10.1002/jbm.b.31360...
) |
Rabbit |
Metaphysis |
5.5 |
16 |
HA |
- |
394 |
36.0 |
HMM |
32.2 |
Keiichi et al. (1717. Keiichi K, Mitsunobu K, Masafumi S, Yutaka D, Toshiaki S. Induction of new bone by basic FGF-loaded porous carbonate apatite implants in femur defects in rats. Clin Oral Implants Res. 2009;20(6):560-5, http://dx.doi.org/10.1111/j.1600-0501.2008.01676.x. http://dx.doi.org/10.1111/j.1600-0501.20...
) |
Rat |
Metaphysis |
4.3 |
12 |
HA |
- |
500 |
52.0 |
Micro-CT |
20.4 |
Keiichi et al. (1717. Keiichi K, Mitsunobu K, Masafumi S, Yutaka D, Toshiaki S. Induction of new bone by basic FGF-loaded porous carbonate apatite implants in femur defects in rats. Clin Oral Implants Res. 2009;20(6):560-5, http://dx.doi.org/10.1111/j.1600-0501.2008.01676.x. http://dx.doi.org/10.1111/j.1600-0501.20...
) |
Rat |
Metaphysis |
4.3 |
12 |
HA |
FGF |
500 |
52.0 |
Micro-CT |
28.7 |
Keiichi et al. (1717. Keiichi K, Mitsunobu K, Masafumi S, Yutaka D, Toshiaki S. Induction of new bone by basic FGF-loaded porous carbonate apatite implants in femur defects in rats. Clin Oral Implants Res. 2009;20(6):560-5, http://dx.doi.org/10.1111/j.1600-0501.2008.01676.x. http://dx.doi.org/10.1111/j.1600-0501.20...
) |
Rat |
Metaphysis |
4.3 |
12 |
HA |
FGF |
500 |
52.0 |
Micro-CT |
28.5 |
Calvo-Guirado et al. (1818. Calvo-Guirado JL, Delgado-Ruíz RA, Ramírez-Fernández MP, Maté-Sánchez JE, Ortiz-Ruiz A, Marcus A. Histomorphometric and mineral degradation study of Ossceram: a novel biphasic B-tricalcium phosphate, in critical size defects in rabbits. Clin Oral Implants Res. 2012;23(6):667-75, http://dx.doi.org/10.1111/j.1600-0501.2011.02193.x. http://dx.doi.org/10.1111/j.1600-0501.20...
) |
Rabbit |
Metaphysis |
6.0 |
8 |
HA+CP |
- |
450 |
95.0 |
HMM |
60.0 |
Okanoue et al. (1919. Okanoue Y, Ikeuchi M, Takemasa R, Tani T, Matsumoto T, Sakamoto M, et al. Comparison of in vivo bioactivity and compressive strength of a novel superporous hydroxyapatite with beta-tricalcium phosphates. Arch Orthop Trauma Surg. 2012;132(11):1603-10, http://dx.doi.org/10.1007/s00402-012-1578-4. http://dx.doi.org/10.1007/s00402-012-157...
) |
Rabbit |
Metaphysis |
5.0 |
12 |
HA |
- |
300 |
85.0 |
Micro-CT |
43.0 |
Okanoue et al. (1919. Okanoue Y, Ikeuchi M, Takemasa R, Tani T, Matsumoto T, Sakamoto M, et al. Comparison of in vivo bioactivity and compressive strength of a novel superporous hydroxyapatite with beta-tricalcium phosphates. Arch Orthop Trauma Surg. 2012;132(11):1603-10, http://dx.doi.org/10.1007/s00402-012-1578-4. http://dx.doi.org/10.1007/s00402-012-157...
) |
Rabbit |
Metaphysis |
5.0 |
12 |
CP |
- |
400 |
75.0 |
Micro-CT |
15.6 |
Su et al. (2020. Su J, Cao L, Yu B, Song S, Liu X, Wang Z, et al. Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair. Int J Nanomedicine. 2012;7:2547-55, http://dx.doi.org/10.2147/IJN.S29819. http://dx.doi.org/10.2147/IJN.S29819...
) |
Rabbit |
Metaphysis |
5.0 |
12 |
Bioglass |
- |
500 |
76.0 |
Micro-CT |
80.0 |
Su et al. (2020. Su J, Cao L, Yu B, Song S, Liu X, Wang Z, et al. Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair. Int J Nanomedicine. 2012;7:2547-55, http://dx.doi.org/10.2147/IJN.S29819. http://dx.doi.org/10.2147/IJN.S29819...
) |
Rabbit |
Metaphysis |
5.0 |
12 |
Bioglass |
- |
500 |
76.0 |
Micro-CT |
48.0 |
Zhao et al. (2121. Zhao J, Shen G, Liu C, Wang S, Zhang W, Zhang X, et al. Enhanced healing of rat calvarial defects with sulfated chitosan-coated calcium-deficient hydroxyapatite/bone morphogenetic protein 2 scaffolds. Tissue Eng Part A. 2012;18(1-2):185-97, http://dx.doi.org/10.1089/ten.tea.2011.0297. http://dx.doi.org/10.1089/ten.tea.2011.0...
) |
Rat |
Calvaria |
5.0 |
8 |
HA |
BMP-2 |
450 |
75.0 |
Micro-CT |
43.0 |
Zhao et al. (2121. Zhao J, Shen G, Liu C, Wang S, Zhang W, Zhang X, et al. Enhanced healing of rat calvarial defects with sulfated chitosan-coated calcium-deficient hydroxyapatite/bone morphogenetic protein 2 scaffolds. Tissue Eng Part A. 2012;18(1-2):185-97, http://dx.doi.org/10.1089/ten.tea.2011.0297. http://dx.doi.org/10.1089/ten.tea.2011.0...
) |
Rat |
Calvaria |
5.0 |
8 |
HA |
BMP-2 |
450 |
75.0 |
Micro-CT |
27.0 |
Zhao et al. (2121. Zhao J, Shen G, Liu C, Wang S, Zhang W, Zhang X, et al. Enhanced healing of rat calvarial defects with sulfated chitosan-coated calcium-deficient hydroxyapatite/bone morphogenetic protein 2 scaffolds. Tissue Eng Part A. 2012;18(1-2):185-97, http://dx.doi.org/10.1089/ten.tea.2011.0297. http://dx.doi.org/10.1089/ten.tea.2011.0...
) |
Rat |
Calvaria |
5.0 |
8 |
HA |
- |
450 |
75.0 |
Micro-CT |
10.0 |
Klijn et al. (2222. Klijn RJ, van den Beucken JJ, Félix Lanao RP, Veldhuis G, Leeuwenburgh SC, Wolke JGC, et al. Three different strategies to obtain porous calcium phosphate cements: comparison of performance in a rat skull bone augmentation model. Tissue Eng Part A. 2012;18(11-12):1171-82, http://dx.doi.org/10.1089/ten.tea.2011.0444. http://dx.doi.org/10.1089/ten.tea.2011.0...
) |
Rat |
Calvaria |
6.0 |
12 |
CP |
- |
500 |
53.2 |
HMM |
10.8 |
Klijn et al. (2222. Klijn RJ, van den Beucken JJ, Félix Lanao RP, Veldhuis G, Leeuwenburgh SC, Wolke JGC, et al. Three different strategies to obtain porous calcium phosphate cements: comparison of performance in a rat skull bone augmentation model. Tissue Eng Part A. 2012;18(11-12):1171-82, http://dx.doi.org/10.1089/ten.tea.2011.0444. http://dx.doi.org/10.1089/ten.tea.2011.0...
) |
Rat |
Calvaria |
6.0 |
12 |
CP |
- |
500 |
44.5 |
HMM |
7.0 |
Klijn et al. (2222. Klijn RJ, van den Beucken JJ, Félix Lanao RP, Veldhuis G, Leeuwenburgh SC, Wolke JGC, et al. Three different strategies to obtain porous calcium phosphate cements: comparison of performance in a rat skull bone augmentation model. Tissue Eng Part A. 2012;18(11-12):1171-82, http://dx.doi.org/10.1089/ten.tea.2011.0444. http://dx.doi.org/10.1089/ten.tea.2011.0...
) |
Rat |
Calvaria |
6.0 |
12 |
CP |
- |
500 |
42.0 |
HMM |
6.8 |
Liu et al. (2323. Liu H, Hu G, Shang P, Shen Y, Nie P, Peng L, et al. Histological characteristics of induced membranes in subcutaneous, intramuscular sites and bone defect. Orthop Traumatol Surg Res. 2013;99(8):959-64, http://dx.doi.org/10.1016/j.otsr.2013.08.009. http://dx.doi.org/10.1016/j.otsr.2013.08...
) |
Rat |
Calvaria |
4.6 |
24 |
Bioglass |
- |
150 |
50.0 |
HMM |
24.0 |
Liu et al. (2323. Liu H, Hu G, Shang P, Shen Y, Nie P, Peng L, et al. Histological characteristics of induced membranes in subcutaneous, intramuscular sites and bone defect. Orthop Traumatol Surg Res. 2013;99(8):959-64, http://dx.doi.org/10.1016/j.otsr.2013.08.009. http://dx.doi.org/10.1016/j.otsr.2013.08...
) |
Rat |
Calvaria |
4.6 |
24 |
Bioglass |
- |
500 |
80.0 |
HMM |
36.0 |
Tayton et al. (2424. Tayton E, Purcell M, Smith JO, Lanham S, Howdle SM, Shakesheff KM, et al. The scale-up of a tissue engineered porous hydroxyapatite polymer composite scaffold for use in bone repair: an ovine femoral condyle defect study. J Biomed Mater Res A. 2015;103(4):1346-56, http://dx.doi.org/10.1002/jbm.a.35279. http://dx.doi.org/10.1002/jbm.a.35279...
) |
Goat |
Metaphysis |
8.0 |
13 |
HA |
BMSCs |
192 |
63.4 |
Micro-CT |
38.1 |
Tayton et al. (2424. Tayton E, Purcell M, Smith JO, Lanham S, Howdle SM, Shakesheff KM, et al. The scale-up of a tissue engineered porous hydroxyapatite polymer composite scaffold for use in bone repair: an ovine femoral condyle defect study. J Biomed Mater Res A. 2015;103(4):1346-56, http://dx.doi.org/10.1002/jbm.a.35279. http://dx.doi.org/10.1002/jbm.a.35279...
) |
Goat |
Metaphysis |
8.0 |
13 |
HA |
- |
192 |
63.4 |
Micro-CT |
24.8 |