ABSTRACT
BACKGROUND AND OBJECTIVES:
Evidence has revealed an important role in the use of medical cannabis, and the interaction of the endocannabinoid system with other drugs for the treatment of chronic neuropathic and nociplastic pain. The objective of this review is to bring an update on published data on doses and care with the use of cannabinoids that demonstrate the interaction in the pathophysiology of chronic pain and its treatment.
CONTENTS:
A research-based review was carried out in the MEDLINE, PUBMED database using the keywords “cannabis and pain”, “endocannabinoid”; “neuropathic pain”; “nociplastic pain”; “drug interactions”.
CONCLUSION:
Drug interaction with cannabinoids requires further scientific knowledge and doses are individual, which makes it difficult to create a protocol for treatment.
Keywords:
Cannabis and pain; Endocannabinoid; Neuropathic pain; Nociplastic pain and drug interactions
HIGHLIGHTS
Every day, cannabinoids for the treatment of chronic pain is establishing itself as an adjuvant treatment; knowing how to administer it depends on an accurate diagnosis of the painful signs and symptoms.
Use of phytocannabinoids for painful symptoms is often non-specific, it does not follow a fixed protocol.
Adverse effects with the use of phytocannabinoids are more common than one might think, and the more we learn about treatments and doses, the longer the list of pharmacological interactions gets.