Oral candidiasis and denture stomatitis in diabetic patients: Systematic review and meta-analysis

MARTORANO-FERNANDES, Loyse; DORNELAS-FIGUEIRA, Louise Morais; MARCELLO-MACHADO, Raissa Micaella; SILVA, Raíra de Brito; MAGNO, Marcela Baraúna; MAIA, Lucianne Cople; DEL BEL CURY, Altair Antoninha

doi:10.1590/1807-3107bor-2020.vol34.0113

Loyse MARTORANO-FERNANDES

Universidade Estadual de Campinas – Unicamp, Piracicaba Dental School, Department of Prosthodontics and Periodontology, Piracicaba, SP, Brazil.

http://orcid.org/0000-0002-5995-5085

Louise Morais DORNELAS-FIGUEIRA

Universidade Estadual de Campinas – Unicamp, Piracicaba Dental School, Department of Prosthodontics and Periodontology, Piracicaba, SP, Brazil.

http://orcid.org/0000-0002-3167-2403

Raissa Micaella MARCELLO-MACHADO

Universidade Estadual de Campinas – Unicamp, Piracicaba Dental School, Department of Prosthodontics and Periodontology, Piracicaba, SP, Brazil.

http://orcid.org/0000-0001-7661-703X

Raíra de Brito SILVA

Universidade Estadual de Campinas – Unicamp, Piracicaba Dental School, Department of Prosthodontics and Periodontology, Piracicaba, SP, Brazil.

http://orcid.org/0000-0002-3268-3235

Marcela Baraúna MAGNO

Universidade Federal do Rio de Janeiro – UFRJ, Department of Pediatric Dentistry and Orthodontics, RJ, Brazil.

http://orcid.org/0000-0003-3618-190X

Lucianne Cople MAIA

Universidade Federal do Rio de Janeiro – UFRJ, Department of Pediatric Dentistry and Orthodontics, RJ, Brazil.

http://orcid.org/0000-0003-1026-9401

Altair Antoninha DEL BEL CURY

Universidade Estadual de Campinas – Unicamp, Piracicaba Dental School, Department of Prosthodontics and Periodontology, Piracicaba, SP, Brazil.

http://orcid.org/0000-0002-4329-0437

Corresponding Author: Altair Antoninha Del Bel Cury. E-mail: altair@unicamp.br

Declaration of Interests: The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript.

Database	Strategy
PubMed	#1 ((((((((((((((((((((((((((((((((((((((((((((((((((((((((Diabetes Mellitus[MeSH Terms]) OR Diabetes Mellitus[Title/Abstract]) OR Diet, Diabetic[Title/Abstract]) OR Prediabetic State[Title/Abstract]) OR Glucose Intolerance[Title/Abstract]) OR Diabetes Mellitus, Type 2[MeSH Terms]) OR type II diabetic[Title/Abstract] OR Diabetes Mellitus, Type 2[Title/Abstract]) OR Type 2 Diabetes Mellitus[Title/Abstract]) OR Diabetes Mellitus, Noninsulin-Dependent[Title/Abstract]) OR Diabetes Mellitus, Ketosis-Resistant[Title/Abstract]) OR Ketosis-Resistant Diabetes Mellitus[Title/Abstract]) OR Diabetes Mellitus, Non Insulin Dependent[Title/Abstract]) OR Non-Insulin-Dependent Diabetes Mellitus[Title/Abstract]) OR Diabetes Mellitus, Stable[Title/Abstract]) OR Stable Diabetes Mellitus[Title/Abstract]) OR Diabetes Mellitus, Type II[Title/Abstract]) OR NIDDM[Title/Abstract]) OR Diabetes Mellitus, Noninsulin Dependent[Title/Abstract]) OR Diabetes Mellitus, Maturity-Onset[Title/Abstract]) OR Diabetes Mellitus, Maturity Onset[Title/Abstract]) OR ((Diabetes Mellitus, Maturity-Onset[Title/Abstract]) OR Diabetes Mellitus, Maturity Onset[Title/Abstract])) OR Maturity-Onset Diabetes Mellitus[Title/Abstract]) OR MODY[Title/Abstract]) OR Diabetes Mellitus, Slow-Onset[Title/Abstract]) OR Slow-Onset Diabetes Mellitus[Title/Abstract]) OR Noninsulin-Dependent Diabetes Mellitus[Title/Abstract]) OR Maturity-Onset Diabetes[Title/Abstract]) OR Type 2 Diabetes[Title/Abstract]) OR Adult-Onset Diabetes Mellitus[Title/Abstract]) OR Diabetes Mellitus, Adult Onset[Title/Abstract]) OR Diabetes Mellitus, Type 1[MeSH Terms]) OR Diabetes Mellitus, Type 1[Title/Abstract]) OR Diabetes Mellitus, Brittle[Title/Abstract]) OR Brittle Diabetes Mellitus[Title/Abstract]) OR Diabetes Mellitus, Insulin-Dependent[Title/Abstract]) OR Insulin-Dependent Diabetes Mellitus[Title/Abstract]) OR Diabetes Mellitus, Juvenile-Onset[Title/Abstract]) OR Juvenile-Onset Diabetes Mellitus[Title/Abstract]) OR Diabetes Mellitus, Ketosis-Prone[Title/Abstract]) OR Ketosis-Prone Diabetes Mellitus[Title/Abstract]) OR Juvenile-Onset Diabetes[Title/Abstract]) OR Diabetes Mellitus, Type I[Title/Abstract]) OR Type 1 Diabetes Mellitus[Title/Abstract]) OR Diabetes Mellitus, Sudden-Onset[Title/Abstract]) OR Mellitus, Sudden-Onset Diabetes[Title/Abstract]) OR Sudden-Onset Diabetes Mellitus[Title/Abstract]) OR ((Mellitus, Sudden-Onset Diabetes[Title/Abstract]) OR Sudden-Onset Diabetes Mellitus[Title/Abstract])) OR Diabetes Mellitus, Insulin-Dependent, 1[Title/Abstract]) OR Insulin-Dependent Diabetes Mellitus 1[Title/Abstract]) OR Type 1 Diabetes[Title/Abstract]) OR Diabetes, Type 1[Title/Abstract]) OR IDDM[Title/Abstract]) OR Autoimmune Diabetes[Title/Abstract]))
	#2 (((((((((((((((((((((((((((((((((((((((((((((((((Candidiasis, Oral[MeSH Terms]) OR Candidiasis, Oral[Title/Abstract]) OR Oral Candidiases[Title/Abstract]) OR Oral Candidiasis[Title/Abstract]) OR Thrush[Title/Abstract]) OR Moniliasis, Oral[Title/Abstract]) OR Moniliases, Oral[Title/Abstract]) OR Oral Moniliases[Title/Abstract]) OR Oral Moniliasis[Title/Abstract]) OR Candida albicans[MeSH Terms]) OR Candida albicans[Title/Abstract]) OR Candida albican[Title/Abstract]) OR ((Candida albicans[Title/Abstract]) OR Candida albican[Title/Abstract])) OR albicans, Candida[Title/Abstract]) OR Candida glabrata[Title/Abstract]) OR Candida glabrata[MeSH Terms]) OR Candida glabratas[Title/Abstract]) OR ((Candida glabratas[Title/Abstract]) OR glabratas, Candida[Title/Abstract])) OR Torulopsis glabrata[Title/Abstract]) OR Torulopsis glabratas[Title/Abstract]) OR ((Torulopsis glabrata[Title/Abstract]) OR Torulopsis glabratas[Title/Abstract])) OR glabrata, Torulopsis[Title/Abstract]) OR Candida tropicalis[MeSH Terms]) OR Candida tropicalis[Title/Abstract]) OR Candida tropicali[Title/Abstract]) OR tropicalis, Candida[Title/Abstract]) OR Candida parapsilosis[MeSH Terms]) OR Candida parapsilosis[Title/Abstract]) OR C. parapsilosis[Title/Abstract]) OR Candida parapsilosis Complex[Title/Abstract]) OR Candida parapsilosis Group[Title/Abstract]) OR C. parapsilosis Complex[Title]) OR Candida orthopsilosis[Title/Abstract]) OR C. orthopsilosis[Title/Abstract]) OR Candida metapsilosis[Title/Abstract]) OR C. metapsilosis[Title/Abstract]) OR Candida[MeSH Terms]) OR Candida[Title]) OR Candidas[Title/Abstract]) OR ((Candida[Title]) OR Candidas[Title/Abstract])) OR Stomatitis, Denture[MeSH Terms]) OR Stomatitis, Denture[Title/Abstract]) OR Denture Stomatitis[Title/Abstract]) OR ((Stomatitis, Denture[Title/Abstract]) OR Denture Stomatitis[Title/Abstract])) OR Denture Stomatitides[Title/Abstract]) OR Stomatitides, Denture[Title/Abstract]) OR ((Denture Stomatitides[Title/Abstract]) OR Stomatitides, Denture[Title/Abstract])) OR Candida species[Title/Abstract]) OR Candida spp[Title/Abstract])))
	#1 AND #2
Scopus	#1 TITLE-ABS-KEY ( diabetes AND mellitus ) OR TITLE-ABS-KEY ( diet, AND diabetic ) OR TITLE-ABS-KEY ( prediabetic AND state ) OR TITLE-ABS-KEY ( glucose AND intolerance ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND type 2 ) OR TITLE-ABS-KEY ( type AND ii AND diabetic ) OR TITLE-ABS-KEY ( type 2 diabetes AND mellitus ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND noninsulin-dependent ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND ketosis-resistant ) OR TITLE-ABS-KEY ( ketosis-resistant AND diabetes AND mellitus ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND non AND insulin AND dependent ) OR TITLE-ABS-KEY ( non-insulin-dependent AND diabetes AND mellitus ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND stable ) OR TITLE-ABS-KEY ( stable AND diabetes AND mellitus ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND type AND ii ) OR TITLE-ABS-KEY ( niddm ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND noninsulin AND dependent ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND maturity-onset ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND maturity AND onset ) OR TITLE-ABS-KEY ( mody ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND slow-onset ) OR TITLE-ABS-KEY ( slow-onset AND diabetes AND mellitus ) OR TITLE-ABS-KEY ( noninsulin-dependent AND diabetes AND mellitus ) OR TITLE-ABS-KEY ( maturity-onset AND diabetes ) OR TITLE-ABS-KEY ( type 2 diabetes ) OR TITLE-ABS-KEY ( adult-onset AND diabetes AND mellitus ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND adult AND onset ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND type 1 ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND brittle ) OR TITLE-ABS-KEY ( brittle AND diabetes AND mellitus ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND insulin-dependent ) OR TITLE-ABS-KEY ( insulin-dependent AND diabetes AND mellitus ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND juvenile-onset ) OR TITLE-ABS-KEY ( juvenile-onset AND diabetes AND mellitus ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND ketosis-prone ) OR TITLE-ABS-KEY ( ketosis-prone AND diabetes AND mellitus ) OR TITLE-ABS-KEY ( juvenile-onset AND diabetes ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND type AND i ) OR TITLE-ABS-KEY ( type 1 diabetes AND mellitus ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND sudden-onset ) OR TITLE-ABS-KEY ( mellitus, AND sudden-onset AND diabetes ) OR TITLE-ABS-KEY ( sudden-onset AND diabetes AND mellitus ) OR TITLE-ABS-KEY ( diabetes AND mellitus, AND insulin-dependent, 1 ) OR TITLE-ABS-KEY ( insulin-dependent AND diabetes AND mellitus 1 ) OR TITLE-ABS-KEY ( type 1 diabetes ) OR TITLE-ABS-KEY ( diabetes, AND type 1 ) OR TITLE-ABS-KEY ( iddm ) OR TITLE-ABS-KEY ( autoimmune AND diabetes )
Scopus	#2 TITLE-ABS-KEY ( candidiasis, AND oral ) OR TITLE-ABS-KEY ( oral AND candidiases ) OR TITLE-ABS-KEY ( oral AND candidiasis ) OR TITLE-ABS-KEY ( thrush ) OR TITLE-ABS-KEY ( moniliasis, AND oral ) OR TITLE-ABS-KEY ( moniliases, AND oral ) OR TITLE-ABS-KEY ( oral AND moniliases ) OR TITLE-ABS-KEY ( oral AND moniliasis ) OR TITLE-ABS-KEY ( candida AND albicans ) OR TITLE-ABS-KEY ( candida AND albican ) OR TITLE-ABS-KEY ( albicans, AND candida ) OR TITLE-ABS-KEY ( candida AND glabrata ) OR TITLE-ABS-KEY ( candida AND glabratas ) OR TITLE-ABS-KEY ( glabratas, AND candida ) OR TITLE-ABS-KEY ( torulopsis AND glabrata ) OR TITLE-ABS-KEY ( torulopsis AND glabratas ) OR TITLE-ABS-KEY ( glabrata, AND torulopsis ) OR TITLE-ABS-KEY ( candida AND tropicalis ) OR TITLE-ABS-KEY ( candida AND tropicali ) OR TITLE-ABS-KEY ( tropicalis, AND candida ) OR TITLE-ABS-KEY ( candida AND parapsilosis ) OR TITLE-ABS-KEY ( c. AND parapsilosis ) OR TITLE-ABS-KEY ( candida AND parapsilosis AND complex ) OR TITLE-ABS-KEY ( candida AND parapsilosis AND group ) OR TITLE-ABS-KEY ( c. AND parapsilosis AND complex ) OR TITLE-ABS-KEY ( candida AND orthopsilosis ) OR TITLE-ABS-KEY ( c. AND orthopsilosis ) OR TITLE-ABS-KEY ( candida AND metapsilosis ) OR TITLE-ABS-KEY ( c. AND metapsilosis ) OR TITLE-ABS-KEY ( candida ) OR TITLE-ABS-KEY ( candidas ) OR TITLE-ABS-KEY ( stomatitis, AND denture ) OR TITLE-ABS-KEY ( denture AND stomatitis ) OR TITLE-ABS-KEY ( denture AND stomatitides ) OR TITLE-ABS-KEY ( stomatitides, AND denture ) OR TITLE-ABS-KEY ( candida AND species ) OR TITLE-ABS-KEY ( candida AND spp ) AND ( LIMIT-TO ( DOCTYPE , “ar” ) )
Scopus	#1 AND #2
Web of Science	#1 TS=(“Diabetes Mellitus” OR “Diet, Diabetic” OR “Prediabetic State” OR “Glucose Intolerance” OR “Diabetes Mellitus, Type 2” OR “type II diabetic” OR “Diabetes Mellitus, Type 2” OR “Type 2 Diabetes Mellitus” OR “Diabetes Mellitus, Noninsulin-Dependent” OR “Diabetes Mellitus, Ketosis-Resistant” OR “Ketosis-Resistant Diabetes Mellitus” OR “Diabetes Mellitus, Non Insulin Dependent” OR “Non-Insulin-Dependent Diabetes Mellitus” OR “Diabetes Mellitus, Stable” OR “Stable Diabetes Mellitus” OR “Diabetes Mellitus, Type II” OR NIDDM OR “Diabetes Mellitus, Noninsulin Dependent” OR “Diabetes Mellitus, Maturity-Onset” OR “Diabetes Mellitus, Maturity Onset” OR “Maturity-Onset Diabetes Mellitus” OR “MODY” OR “Diabetes Mellitus, Slow-Onset” OR “Slow-Onset Diabetes Mellitus” OR “Noninsulin-Dependent Diabetes Mellitus” OR “Maturity-Onset Diabetes” OR “Type 2 Diabetes” OR “Adult-Onset Diabetes Mellitus” OR “Diabetes Mellitus, Adult Onset” OR “Diabetes Mellitus, Type 1” OR “Diabetes Mellitus, Brittle” OR “Brittle Diabetes Mellitus” OR “Diabetes Mellitus, Insulin-Dependent” OR “Insulin-Dependent Diabetes Mellitus” OR “Diabetes Mellitus, Juvenile-Onset” OR “Juvenile-Onset Diabetes Mellitus” OR “Diabetes Mellitus, Ketosis-Prone” OR “Ketosis-Prone Diabetes Mellitus” OR “Juvenile-Onset Diabetes” OR “Diabetes Mellitus, Type I” OR “Type 1 Diabetes Mellitus” OR “Diabetes Mellitus, Sudden-Onset” OR “Mellitus, Sudden-Onset Diabetes” OR “Sudden-Onset Diabetes Mellitus” OR “Diabetes Mellitus, Insulin-Dependent, 1” OR “Insulin-Dependent Diabetes Mellitus 1” OR “Type 1 Diabetes” OR “Diabetes, Type 1” OR “IDDM” OR “Autoimmune Diabetes”)
	#2 TS=(“Candidiasis, Oral” OR “Oral Candidiasis” OR “Oral Candidiases” OR Thrush OR “Moniliasis, Oral” OR “Moniliases, Oral” OR “Oral Moniliases” OR “Oral Moniliasis” OR “Candida albicans” OR “Candida albican” OR “albicans, Candida” OR “Candida glabrata” OR “Candida glabrata” OR “Candida glabratas” OR “Torulopsis glabrata” OR “Torulopsis glabratas” OR “glabrata, Torulopsis” OR “Candida tropicalis” OR “Candida tropicali” OR “tropicalis, Candida” OR “Candida parapsilosis” OR “C. parapsilosis” OR “Candida parapsilosis Complex” OR “Candida parapsilosis Group” OR “C. parapsilosis Complex” OR “Candida orthopsilosis” OR “C. orthopsilosis” OR Candida OR Candidas OR “Stomatitis, Denture” OR “Denture Stomatitis” OR “Denture Stomatitides” OR “Stomatitides, Denture” OR “Candida species” OR “Candida spp”)
	#1 AND #2
Open Grey	#1 (“Diabetes Mellitus” OR “Diet, Diabetic” OR “Prediabetic State” OR “Glucose Intolerance” OR “Diabetes Mellitus, Type 2” OR “type II diabetic” OR “Diabetes Mellitus, Type 2” OR “Type 2 Diabetes Mellitus” OR “Diabetes Mellitus, Noninsulin-Dependent” OR “Diabetes Mellitus, Ketosis-Resistant” OR “Ketosis-Resistant Diabetes Mellitus” OR “Diabetes Mellitus, Non Insulin Dependent” OR “Non-Insulin-Dependent Diabetes Mellitus” OR “Diabetes Mellitus, Stable” OR “Stable Diabetes Mellitus” OR “Diabetes Mellitus, Type II” OR “NIDDM” OR “Diabetes Mellitus, Noninsulin Dependent” OR “Diabetes Mellitus, Maturity-Onset” OR “Diabetes Mellitus, Maturity Onset” OR “Maturity-Onset Diabetes Mellitus” OR “MODY” OR “Diabetes Mellitus, Slow-Onset” OR “Slow-Onset Diabetes Mellitus” OR “Noninsulin-Dependent Diabetes Mellitus” OR “Maturity-Onset Diabetes” OR “Type 2 Diabetes” OR “Adult-Onset Diabetes Mellitus” OR “Diabetes Mellitus, Adult Onset” OR “Diabetes Mellitus, Type 1” OR “Diabetes Mellitus, Brittle” OR “Brittle Diabetes Mellitus” OR “Diabetes Mellitus, Insulin-Dependent” OR “Insulin-Dependent Diabetes Mellitus” OR “Diabetes Mellitus, Juvenile-Onset” OR “Juvenile-Onset Diabetes Mellitus” OR “Diabetes Mellitus, Ketosis-Prone” OR “Ketosis-Prone Diabetes Mellitus” OR “Juvenile-Onset Diabetes” OR “Diabetes Mellitus, Type I” OR “Type 1 Diabetes Mellitus” OR “Diabetes Mellitus, Sudden-Onset” OR “Mellitus, Sudden-Onset Diabetes” OR “Sudden-Onset Diabetes Mellitus” OR “Diabetes Mellitus, Insulin-Dependent, 1” OR “Insulin-Dependent Diabetes Mellitus 1” OR “Type 1 Diabetes” OR “Diabetes, Type 1” OR “IDDM” OR “Autoimmune Diabetes”)
	#2 (“Candidiasis, Oral” OR “Oral Candidiasis” OR “Oral Candidiases” OR Thrush OR “Moniliasis, Oral” OR “Moniliases, Oral” OR “Oral Moniliases” OR “Oral Moniliasis” OR “Candida albicans” OR “Candida albican” OR “albicans, Candida” OR “Candida glabrata” OR “Candida glabrata” OR “Candida glabratas” OR “Torulopsis glabrata” OR “Torulopsis glabratas” OR “glabrata, Torulopsis” OR “Candida tropicalis” OR “Candida tropicali” OR “tropicalis, Candida” OR “Candida parapsilosis” OR “C. parapsilosis” OR “Candida parapsilosis Complex” OR “Candida parapsilosis Group” OR “C. parapsilosis Complex” OR “Candida orthopsilosis” OR “C. orthopsilosis” OR Candida OR Candidas OR “Stomatitis, Denture” OR “Denture Stomatitis” OR “Denture Stomatitides” OR “Stomatitides, Denture” OR “Candida species” OR “Candida spp”)
	#1 AND #2
Cochrane Library	#1 MeSH descriptor: [Diabetes Mellitus] explode all trees
	#2 Diabetes Mellitus OR Diet, Diabetic OR Prediabetic State OR Glucose Intolerance
	#3 MeSH descriptor: [Diabetes Mellitus, Type 2] explode all trees
	#4 Diabetes Mellitus, Type 2 OR type II diabetic OR Diabetes Mellitus, Type 2 OR Type 2 Diabetes Mellitus OR Diabetes Mellitus, Noninsulin-Dependent OR Diabetes Mellitus, Ketosis-Resistant OR Ketosis-Resistant Diabetes Mellitus OR Diabetes Mellitus, Non Insulin Dependent OR Non-Insulin-Dependent Diabetes Mellitus OR Diabetes Mellitus, Stable OR Stable Diabetes Mellitus OR Diabetes Mellitus, Type II OR NIDDM OR Diabetes Mellitus, Noninsulin Dependent OR Diabetes Mellitus, Maturity-Onset OR Diabetes Mellitus, Maturity Onset OR Maturity-Onset Diabetes Mellitus OR MODY OR Diabetes Mellitus, Slow-Onset OR Slow-Onset Diabetes Mellitus OR Noninsulin-Dependent Diabetes Mellitus OR Maturity-Onset Diabetes OR Type 2 Diabetes OR Adult-Onset Diabetes Mellitus OR Diabetes Mellitus, Adult Onset
	#5 MeSH descriptor: [Diabetes Mellitus, Type 1] explode all trees
	#6 Diabetes Mellitus, Type 1 OR Diabetes Mellitus, Brittle OR Brittle Diabetes Mellitus OR Diabetes Mellitus, Insulin-Dependent OR Insulin-Dependent Diabetes Mellitus OR Diabetes Mellitus, Juvenile-Onset OR Juvenile-Onset Diabetes Mellitus OR Diabetes Mellitus, Ketosis-Prone OR Ketosis-Prone Diabetes Mellitus OR Juvenile-Onset Diabetes OR Diabetes Mellitus, Type I OR Type 1 Diabetes Mellitus OR Diabetes Mellitus, Sudden-Onset OR Mellitus, Sudden-Onset Diabetes OR Sudden-Onset Diabetes Mellitus OR Diabetes Mellitus, Insulin-Dependent, 1 OR Insulin-Dependent Diabetes Mellitus 1 OR Type 1 Diabetes OR Diabetes, Type 1 OR IDDM OR Autoimmune Diabetes
	#7 #1 or #2 or #3 or #4 or #5 or #6
	#8 MeSH descriptor: [Candidiasis, oral] explode all trees
	#9 Candidiasis, Oral OR Oral Candidiases OR Oral Candidiasis OR Thrush OR Moniliasis, Oral OR Moniliases, Oral OR Oral Moniliases OR Oral Moniliasis
	#10 MeSH descriptor: [Candida albicans] explode all trees
	#11 Candida albicans OR Candida albican OR albicans, Candida
	#12 MeSH descriptor: [Candida glabrata] explode all trees
	#13 Candida glabrata OR Candida glabratas OR Torulopsis glabrata OR Torulopsis glabratas OR glabrata, Torulopsis
	#14 MeSH descriptor: [Candida tropicalis] explode all trees
	#15 Candida tropicalis OR Candida tropicali OR tropicalis, Candida
	#16 MeSH descriptor: [Candida parapsilosis] explode all trees
	#17 Candida parapsilosis OR C. parapsilosis OR Candida parapsilosis Complex OR Candida parapsilosis Group OR C. parapsilosis Complex OR Candida orthopsilosis OR C. orthopsilosis OR Candida metapsilosis OR C. metapsilosis
	#18 MeSH descriptor: [Candida] explode all trees
	#19 Candida OR Candidas
	#20 MeSH descriptor: [Stomatitis, denture] explode all trees
	#21 Stomatitis, Denture OR Denture Stomatitis OR Denture Stomatitides OR Stomatitides, Denture OR Candida species OR Candida spp
	#22 #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21
	#23 #7 and #22
Lilacs	#1 (tw:((tw:(Diabetes Mellitus)) OR (tw:(Diet, Diabetic)) OR (tw:(Prediabetic State)) OR (tw:(Glucose Intolerance)) OR (tw:(Diabetes Mellitus, Type 2)) OR (tw:(type II diabetic)) OR (tw:(Diabetes Mellitus, Type 2)) OR (tw:(Type 2 Diabetes Mellitus)) OR (tw:(Diabetes Mellitus, Noninsulin-Dependent)) OR (tw:(Diabetes Mellitus, Ketosis-Resistant)) OR (tw:(Ketosis-Resistant Diabetes Mellitus)) OR (tw:(Diabetes Mellitus, Non Insulin Dependent)) OR (tw:(Non-Insulin-Dependent Diabetes Mellitus)) OR (tw:(Diabetes Mellitus, Stable)) OR (tw:(Stable Diabetes Mellitus)) OR (tw:(Diabetes Mellitus, Type II)) OR (tw:(NIDDM)) OR (tw:(Diabetes Mellitus, Noninsulin Dependent)) OR (tw:(Diabetes Mellitus, Maturity-Onset)) OR (tw:(Diabetes Mellitus, Maturity Onset)) OR (tw:(Maturity-Onset Diabetes Mellitus)) OR (tw:(MODY)) OR (tw:(Diabetes Mellitus, Slow-Onset)) OR (tw:(Slow-Onset Diabetes Mellitus)) OR (tw:(Noninsulin-Dependent Diabetes Mellitus)) OR (tw:(Maturity-Onset Diabetes)) OR (tw:(Type 2 Diabetes)) OR (tw:(Adult-Onset Diabetes Mellitus)) OR (tw:(Diabetes Mellitus, Adult Onset)) OR (tw:(Diabetes Mellitus, Type 1)) OR (tw:(Diabetes Mellitus, Brittle)) OR (tw:(Brittle Diabetes Mellitus)) OR (tw:(Diabetes Mellitus, Insulin-Dependent)) OR (tw:(Insulin-Dependent Diabetes Mellitus)) OR (tw:(Diabetes Mellitus, Juvenile-Onset)) OR (tw:(Juvenile-Onset Diabetes Mellitus)) OR (tw:(Diabetes Mellitus, Ketosis-Prone)) OR (tw:(Ketosis-Prone Diabetes Mellitus)) OR (tw:(Juvenile-Onset Diabetes)) OR (tw:(Diabetes Mellitus, Type I)) OR (tw:(Type 1 Diabetes Mellitus)) OR (tw:(Diabetes Mellitus, Sudden-Onset)) OR (tw:(Mellitus, Sudden-Onset Diabetes)) OR (tw:(Sudden-Onset Diabetes Mellitus)) OR (tw:(Diabetes Mellitus, Insulin-Dependent, 1)) OR (tw:(Insulin-Dependent Diabetes Mellitus 1)) OR (tw:(Type 1 Diabetes)) OR (tw:(Diabetes, Type 1)) OR (tw:(IDDM)) OR (tw:(Autoimmune Diabetes))))
Lilacs	#2 (tw:((tw:(Candidiasis, Oral)) OR (tw:(Oral Candidiases)) OR (tw:(Oral Candidiasis)) OR (tw:(Thrush)) OR (tw:(Moniliasis, Oral)) OR (tw:(Moniliases, Oral)) OR (tw:(Oral Moniliases)) OR (tw:(Oral Moniliasis)) OR (tw:(Candida albicans)) OR (tw:(Candida albican)) OR (tw:(albicans, Candida)) OR (tw:(Candida glabrata)) OR (tw:(Candida glabrata)) OR (tw:(Candida glabratas)) OR (tw:(Torulopsis glabrata)) OR (tw:(Torulopsis glabratas)) OR (tw:(glabrata, Torulopsis)) OR (tw:(Candida tropicalis)) OR (tw:(Candida tropicali)) OR (tw:(tropicalis, Candida)) OR (tw:(Candida parapsilosis)) OR (tw:(C. parapsilosis)) OR (tw:(Candida parapsilosis Complex)) OR (tw:(Candida parapsilosis Group)) OR (tw:(C. parapsilosis Complex)) OR (tw:(Candida orthopsilosis)) OR (tw:(C. orthopsilosis)) OR (tw:(Candida metapsilosis)) OR (tw:(C. metapsilosis)) OR (tw:(Candida)) OR (tw:(Candidas)) OR (tw:(Stomatitis, Denture)) OR (tw:(Denture Stomatitis)) OR (tw:(Denture Stomatitides)) OR (tw:(Stomatitides, Denture)) OR (tw:(Candida species)) OR (tw:(Candida spp))))
Lilacs	#1 AND #2
Embase	#1 diabetes:ti,ab,kw AND mellitus:ti,ab,kw OR (diet,:ti,ab,kw AND diabetic:ti,ab,kw) OR (prediabetic:ti,ab,kw AND state:ti,ab,kw) OR (glucose:ti,ab,kw AND intolerance:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND ‘type 2’:ti,ab,kw) OR (type:ti,ab,kw AND ii:ti,ab,kw AND diabetic:ti,ab,kw) OR (‘type 2 diabetes’:ti,ab,kw AND mellitus:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND ‘noninsulin dependent’:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND ‘ketosis resistant’:ti,ab,kw) OR (‘ketosis resistant’:ti,ab,kw AND diabetes:ti,ab,kw AND mellitus:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND non:ti,ab,kw AND insulin:ti,ab,kw AND dependent:ti,ab,kw) OR (‘non insulin dependent’:ti,ab,kw AND diabetes:ti,ab,kw AND mellitus:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND stable:ti,ab,kw) OR (stable:ti,ab,kw AND diabetes:ti,ab,kw AND mellitus:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND type:ti,ab,kw AND ii:ti,ab,kw) OR niddm:ti,ab,kw OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND noninsulin:ti,ab,kw AND dependent:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND ‘maturity onset’:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND maturity:ti,ab,kw AND onset:ti,ab,kw) OR mody:ti,ab,kw OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND ‘slow onset’:ti,ab,kw) OR (‘slow onset’:ti,ab,kw AND diabetes:ti,ab,kw AND mellitus:ti,ab,kw) OR (‘noninsulin dependent’:ti,ab,kw AND diabetes:ti,ab,kw AND mellitus:ti,ab,kw) OR (‘maturity onset’:ti,ab,kw AND diabetes:ti,ab,kw) OR ‘type 2 diabetes’:ti,ab,kw OR (‘adult onset’:ti,ab,kw AND diabetes:ti,ab,kw AND mellitus:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND adult:ti,ab,kw AND onset:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND ‘type 1’:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND brittle:ti,ab,kw) OR (brittle:ti,ab,kw AND diabetes:ti,ab,kw AND mellitus:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND ‘insulin dependent’:ti,ab,kw) OR (‘insulin dependent’:ti,ab,kw AND diabetes:ti,ab,kw AND mellitus:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND ‘juvenile onset’:ti,ab,kw) OR (‘juvenile onset’:ti,ab,kw AND diabetes:ti,ab,kw AND mellitus:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND ‘ketosis prone’:ti,ab,kw) OR (‘ketosis prone’:ti,ab,kw AND diabetes:ti,ab,kw AND mellitus:ti,ab,kw) OR (‘juvenile onset’:ti,ab,kw AND diabetes:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND type:ti,ab,kw AND i:ti,ab,kw) OR (‘type 1 diabetes’:ti,ab,kw AND mellitus:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND ‘sudden onset’:ti,ab,kw) OR (mellitus,:ti,ab,kw AND ‘sudden onset’:ti,ab,kw AND diabetes:ti,ab,kw) OR (‘sudden onset’:ti,ab,kw AND diabetes:ti,ab,kw AND mellitus:ti,ab,kw) OR (diabetes:ti,ab,kw AND mellitus,:ti,ab,kw AND ‘insulin-dependent, 1’:ti,ab,kw) OR (‘insulin dependent’:ti,ab,kw AND diabetes:ti,ab,kw AND ‘mellitus 1’:ti,ab,kw) OR ‘type 1 diabetes’:ti,ab,kw OR (diabetes,:ti,ab,kw AND ‘type 1’:ti,ab,kw) OR iddm:ti,ab,kw OR (autoimmune:ti,ab,kw AND diabetes:ti,ab,kw)
Embase	#2 candidiasis,:ti,ab,kw AND oral:ti,ab,kw OR (oral:ti,ab,kw AND candidiases:ti,ab,kw) OR (oral:ti,ab,kw AND candidiasis:ti,ab,kw) OR thrush:ti,ab,kw OR (moniliasis,:ti,ab,kw AND oral:ti,ab,kw) OR (moniliases,:ti,ab,kw AND oral:ti,ab,kw) OR (oral:ti,ab,kw AND moniliases:ti,ab,kw) OR (oral:ti,ab,kw AND moniliasis:ti,ab,kw) OR (candida:ti,ab,kw AND albicans:ti,ab,kw) OR (candida:ti,ab,kw AND albican:ti,ab,kw) OR (albicans,:ti,ab,kw AND candida:ti,ab,kw) OR (candida:ti,ab,kw AND glabrata:ti,ab,kw) OR (candida:ti,ab,kw AND glabratas:ti,ab,kw) OR (glabratas,:ti,ab,kw AND candida:ti,ab,kw) OR (torulopsis:ti,ab,kw AND glabrata:ti,ab,kw) OR (torulopsis:ti,ab,kw AND glabratas:ti,ab,kw) OR (glabrata,:ti,ab,kw AND torulopsis:ti,ab,kw) OR (candida:ti,ab,kw AND tropicalis:ti,ab,kw) OR (candida:ti,ab,kw AND tropicali:ti,ab,kw) OR (tropicalis,:ti,ab,kw AND candida:ti,ab,kw) OR (candida:ti,ab,kw AND parapsilosis:ti,ab,kw) OR (c.:ti,ab,kw AND parapsilosis:ti,ab,kw) OR (candida:ti,ab,kw AND parapsilosis:ti,ab,kw AND complex:ti,ab,kw) OR (candida:ti,ab,kw AND parapsilosis:ti,ab,kw AND group:ti,ab,kw) OR (c.:ti,ab,kw AND parapsilosis:ti,ab,kw AND complex:ti,ab,kw) OR (candida:ti,ab,kw AND orthopsilosis:ti,ab,kw) OR (c.:ti,ab,kw AND orthopsilosis:ti,ab,kw) OR (candida:ti,ab,kw AND metapsilosis:ti,ab,kw) OR (c.:ti,ab,kw AND metapsilosis:ti,ab,kw) OR candida:ti,ab,kw OR candidas:ti,ab,kw OR (stomatitis,:ti,ab,kw AND denture:ti,ab,kw) OR (denture:ti,ab,kw AND stomatitis:ti,ab,kw) OR (denture:ti,ab,kw AND stomatitides:ti,ab,kw) OR (stomatitides,:ti,ab,kw AND denture:ti,ab,kw) OR (candida:ti,ab,kw AND species:ti,ab,kw) OR (candida:ti,ab,kw AND spp:ti,ab,kw)

Guideline	Checklist	Established criteria
Study sample representative?	Source of sample	0: Participants of the same center and homogeneity of the sample
		+ Participants from different centers
		++ Participants from different centers and imbalance in the sample
	Sampling method	0: Samples paired by gender, age and sample size
		+: It stopped the sample only in some aspects
		++: Did not match or did not make it clear the pairing of samples
	Sample size	0: The study performed a sample calculation
		+: No sample calculation was performed, but the sample is representative
		++: Did not do sample calculation and sample is not representative
	Entry criteria/	0: Clearly defined inclusion and exclusion criteria, excluding smokers, alcoholics, immunocompromised and other comorbidities
	exclusions	++: The authors stated that the patients were exclusively diabetic, but it was not mentioned if there were excluded smokers, alcoholics, immunocompromised, and other comorbidities
Control group accetable?	Definition of controls	0: Adequate criteria for inclusion of controls (pairing with the exposed group)
		+: Partial matching of criteria for controls
		++: Not matching or not defined
	Source of controls	0: Participants of the same center and homogeneity of the sample
		+ Participants from different centers
		++ Participants from different centers and imbalance in the sample
	Matching / randomisation	0: If the control group is paired with experimental (exposed) in gender, age, sample size and if there was randomization
		+: There was pairing in some aspects; There was no matching by sample size
		++: Not matched or not clear.
Quality of measurements and outcomes?	Validity	0: The study uses validated diagnostic method
	Validity	++: Does not use previously validated method
	Reproducibility	0: Calibrated calibrator (with kappa value)
		+: Expert opinion or evaluator calibrated without kappa
		++: Did not use expert opinion or calibrated evaluator
	Blindness	0: Examiner is blind
		+: There is only blinding of the statistician
		++: There is no type of blinding
	Quality control	0: More than one valued calibrator with Kappa value
		+: Two calibrated raters (no Kappa value) or one calibrated rater (Kappa value)
		++: An uncalibrated evaluator
	Missing data	0: no data loss
		+: data loss less than 20%
		++: data loss greater than 20%
	Confounding factors	0: there is no confounding factor
		+: is there any confounding factor
		++: there are serious confounding factors
	Distortion reduced by analysis	0: no distortion or analysis was adjusted for distortions
		+: partially adjusted analysis to reduce confounding
		++: unadjusted analysis

Guideline	Checklist	Al-Maweri et al., 2013²⁹	DorockaBobkowska et al., 1996.¹²	Radović et al., 2014³⁰	Saini et al., 2010³¹	Bissong et al., 2015²⁸	Trentin et al., 2017³²	Obradović et al., 2011¹¹
Study design appropriate to objectives?	Cross-sectional	x	x	x	x	x	x
	Cohort							x
	Controlled trial
	Cause control
Study sample representative?	Source of sample	0	+	+	+	+	0	0
	Sampling method	0	+	++	0	++	+	+
	Sample size	0	+	+	0	+	+	+
	Entry criteria/	0	0	++	0	++	++	++
	exclusions	0	0	++	0	++	++	++
	Non-respondents	NA	NA	NA	NA	NA	NA	NA
Control group accetable?	Definition of controls	0	+	0	0	+	+	++
	Source of controls	0	+	0	0	0	0	0
	Matching / randomisation	+	++	++	0	++	++	+
	Comparable characteristics	0	+	+	0	++	++	+
Quality of measurements and outcomes?	Validity	0	0	0	0	++	++	++
	Reproducibility	+	++	+	+	++	0	++
	Blindness	++	++	++	++	++	++	++
	Quality control	++	++	+	++	++	0	++
Completeness?	Compliance	NA	NA	NA	NA	NA	NA	NA
	Drop outs	NA	NA	NA	NA	NA	NA	NA
	Deaths	NA	NA	NA	NA	NA	NA	NA
	Missing data	0	0	+	0	0	0	0
Distorting influences?	Extraneous treatments	NA	NA	NA	NA	NA	NA	NA
	Contamination	NA	NA	NA	NA	NA	NA	NA
	Changes over time	NA	NA	NA	NA	NA	NA	NA
	Confounding factors	0	0	++	0	++	++	++
	Distortion reduced by analysis	0	++	++	0	++	++	++
Summary questions	Bias – Are the results	No	Yes	No	No	Yes	Yes	Yes
	erroneously biased in a certain direction?	No	Yes	No	No	Yes	Yes	Yes
	Confounding – Are there any serious confounding or other distortin influences?	No	No	Yes	No	Yes	Yes	Yes
	Chance – Is it likely that the results occurred by chance?	No	No	No	No	Yes	Yes	Yes

Author, year and location of the study	Study design	Population	n		Diagnostic of Diabetes Mellitus	Methods	Outcome	Rate of disease in diabetic patients	Rate of disease in non - diabetic patients
Author, year and location of the study	Study design	Population	(diabetic)	(non-diabetic)	Diagnostic of Diabetes Mellitus	Methods	Outcome	Rate of disease in diabetic patients	Rate of disease in non - diabetic patients
Al-Maweri AS, 2013.²⁹ Malaysia	Cross-sectional	Adults	n = 391	n = 391	Non-diabetic control subjects, identified by their normal fasting blood glucose levels	Visual examination of the mouth was carried out by a single examiner who was supervised and assessed by an oral medicine specialist. Diagnostic criteria for abnormalities of the oral mucosa were following World Health Organization (WHO) guidelines		n = 45 (11.5%)	n = 26 (6.6%)
Al-Maweri AS, 2013.²⁹ Malaysia	Cross-sectional	Both gender	Type II	n = 391			Denture stomatitis	(p = 0.018).	(p = 0.018)
Dorocka-Bobkowska B, 1996.¹² Poland	Cross-sectional	Adults and elderly. Both gender	n = 70	n = 58	The patients were regarded as non-diabetics or diabetics of complete physical examination and fasting plasma glucose levels.	All subjects underwent a routine oral examination. The patients with denture stomatitis were categorized according to the classification of NEWTON. The prevalence of yeasts in the mouth was estimated by culture. Swabs were collected from areas of palatal mucosa, inoculated on to Sabouraud’s médium with chloramphenicol (bioMerieux) and incubated at 37°C for 48h. All yeast isolations were identified by the germ-tube formation and by API	Denture stomatitis	n = 41 (58.6%)	n = 21 (36.2%)
Dorocka-Bobkowska B, 1996.¹² Poland	Cross-sectional	Adults and elderly. Both gender	Type II	n = 58			Denture stomatitis	(p < 0.01)	n = 21 (36.2%)
Radović K, 2014.³⁰ Serbia	Cross-sectional	Adults	n = 42	n = 42	No results	The presence of denture stomatitis and potential contributing factors, such as denture cleanliness and stability, were evaluated 1 year after the immediate denture insertion. Two independent, calibrated examiners performed oral examinations and diagnosed denture stomatitis according to the Newton classification	Denture stomatitis	n = 22 (61.1%)	n = 16 (38.1%)
Radović K, 2014.³⁰ Serbia	Cross-sectional	Both gender	Type II	n = 42	No results		Denture stomatitis	(p = 0.04)	n = 16 (38.1%)
Saini R, 2010,³¹ Malaysia	Cross-sectional	Adults. Both gender	n = 420	n = 420	No results	Visual examination (Extra and intra-oral) of the mouth was carried out by a single examiner. Any abnormality of the oral mucosa was diagnosed according to diagnostic criteria based on those described in the WHO guide to epidemiology and diagnosis of oral mucosal diseases	Denture stomatitis	n = 45 (10.7%)	n = 26 (6.2%)
Saini R, 2010,³¹ Malaysia	Cross-sectional	Adults. Both gender	Type II	n = 420	No results		Denture stomatitis	(p = 0.018)	n = 26 (6.2%)
Bissong M, 2015,²⁸ Southwest Cameroon	Cross-sectional	Adults. Both gender	n = 149	n = 102	Diabetic as confirmed by fasting blood sugar levels ≥ 126 mg/dl or the use of hypoglycemic drugs	Clinical oral examination was done by a trained and calibrated dentist to assess dental plaque, calculus, sores, periodontal pockets, swollen/bleeding gums, dental caries, bad breath, and oral candidiasis. Oral candidiasis was recorded as either present or absent	Oral candidiasis	n = 32 (21.5%)	n = 30 (2.9%)
Bissong M, 2015,²⁸ Southwest Cameroon	Cross-sectional	Adults. Both gender	Didn’t specify the type	n = 102			Oral candidiasis	(p < 0,01)	n = 30 (2.9%)
Trentin MS, 2017,³¹ Brazil	Cross-sectional	Adults. Both gender	n = 116	n = 134	The diabetic was diagnosed through the criteria proposed by the World Health Organization16 and by the Guidelines of the Brazilian Society of Diabetes	For clinical examination, all anatomical sites were analyzed (lips, tongue, gingiva, and palate) and information was filled out on proper clinical records by two previously trained examiners. Kappa test was used to assess inter-examiner reproducibility, which resulted in 80% concordance.	Oral candidiasis	n = 8	n = 19
			Type II					(6.8%)	(14.1%)

Obradović RR, 2011,¹¹ Serbia	Cohort	Adults. Both gender	n = 100	n = 50	Glycosylated hemoglobin (HbA1C) and fasting blood glucose level were measured to assess glycemic control	Oral candidiasis had been diagnosed based on both clinical assessment and laboratory identification of Candida species.	Oral candidiasis	For type I	n = 2
			50 Type I					n = 28 (28%)	-2%
			50 Type II					For type II
								n = 31 (31%)

Participants (studies)	Certainty assessment						Summary of findings
Participants (studies)	Risk of bias	Inconsistency	Indirectness	Imprecision	Other considerations^#	Overall certainty of evidence	Study event rates (%)		Relative effect (95% CI)	Anticipated absolute effects
Follow up	Risk of bias	Inconsistency	Indirectness	Imprecision	Other considerations^#	Overall certainty of evidence	with non-diabetics	with diabetics	Relative effect (95% CI)	risk with non-diabetics	risk difference with diabetics
Oral candidiasis
651 (3 observational studies)	serious^a	very serious^b	not serious	very serious^c,d	none	⨁◯◯◯	51/286 (17.8%)	99/365 (27.1%)	OR 1.40 (0.96 to 2.04)	178 per 1.000	55 more per 1.000 (from 6 fewer to 129 more)
651 (3 observational studies)	serious^a	very serious^b	not serious	very serious^c,d	none	VERY LOW	51/286 (17.8%)	99/365 (27.1%)	OR 1.40 (0.96 to 2.04)	178 per 1.000	55 more per 1.000 (from 6 fewer to 129 more)
Denture stomatitis
1834 (4 observational studies)	not serious	not serious	serious^e	very serious^c,d	none	⨁◯◯◯	89/911 (9.8%)	153/923 (16.6%)	OR 1.92 (1.42 to 2.59)	98 per 1.000	74 more per 1.000 (from 36 more to 121 more)
1834 (4 observational studies)	not serious	not serious	serious^e	very serious^c,d	none	VERY LOW	89/911 (9.8%)	153/923 (16.6%)	OR 1.92 (1.42 to 2.59)	98 per 1.000	74 more per 1.000 (from 36 more to 121 more)

[1] Corresponding Author: Altair Antoninha Del Bel Cury. E-mail: altair@unicamp.br

Brasil

Brasil

Oral candidiasis and denture stomatitis in diabetic patients: Systematic review and meta-analysis

Abstract