|
IL6
|
rs1800795 (-174G>C) |
63 adults (Venezuela) |
MMF, CsA, CS (3 y) |
-174G>C; no association with AR or chronic rejection |
Gendzekhadze et al., 2006Gendzekhadze K, Rivas-Vetencourt P, Montano RF. Risk of adverse post-transplant events after kidney allograft transplantation as predicted by CTLA-4 +49 and TNF- alpha -308 single nucleotide polymorphisms: a preliminary study. Transpl Immunol . 2006;16(3-4):194-199. https://doi.org/10.1016/j.trim.2006.09.001.
https://doi.org/https://doi.org/10.1016/...
|
| rs10499563 (-6331T>C) |
231 adults (Tunisia) |
MMF-based ISS therapy (20 y) |
-174G>C: no association with AR or chronic rejection |
Dhaouadi et al., 2013Dhaouadi T, Sfar I, Bardi R, Jendoubi-Ayed S, Abdallah TB, Ayed K, et al. Cytokine gene polymorphisms in kidney transplantation. Transplant Proc . 2013;45(6):2152-2157.
|
| 92 adults (Saudi Arabia) |
MMF, Tac, mTORi, CsA, CS (5 y) |
-174G>C: no association with AR |
Gaafar et al., 2014Gaafar A, Iqniebi A, Sheereen A, Eldali A, Turpeinen H, Adra C, et al. Study of the cytokine polymorphisms in correlation to rejection and graft survival in renal allograft donors and recipients from a homogenous Saudi population. Transpl Immunol. 2014;30(1):34-39.
|
|
IL12A
|
rs568408 (c.*121G>A) |
918 adults (USA) |
MMF, Tac, CsA, CS (6 m) |
rs568408 A: no association with leukopenia |
Jacobson et al., 2011Jacobson PA, Schladt D, Oetting WS, Leduc R, Guan W, Matas AJ, et al. Genetic determinants of mycophenolate- related anemia and leukopenia after transplantation. Transplant ation . 2011;91(3):309-316.
|
| 189 adults (Dominos study) |
EC-MPS, CsA, CS (6 m) |
rs568408G>A: no association with AR, leukopenia, anemia or diarrhea |
Woillard et al., 2014Woillard JB, Picard N, Thierry A, Touchard G, Marquet P; DOMINOS study group. Associations between polymorphisms in target, metabolism, or transport proteins of mycophenolate sodium and therapeutic or adverse effects in kidney transplant patients. Pharmacogenet Genomics . 2014;24(5):256-262.
|
|
IL12B
|
rs3212227 (c.*159T>G, 1188A>C) |
50 adults (Japan) |
MMF, Tac, CS (1 y) |
1188A>C: no association with chronic graft nephropathy |
Satoh et al., 2007Satoh S, Saito M, Inoue K, Miura M, Komatsuda A, Habuchi T. Association of cytokine polymorphisms with subclinical progressive chronic allograft nephropathy in Japanese renal transplant recipients: preliminary study. Int J Urol. 2007;14(11):990-994.
|
| 253 adults (France) |
MMF, Aza, calcineurin inhibitor, CS |
rs3212227 C: no association with AR, DGF or graft survival |
Hoffmann et al., 2009Hoffmann TW, Halimi JM, Büchler M, Velge-Roussel F, Al- Najjar A, Marliere JF, et al. Impact of a polymorphism in the IL-12p40 gene on the outcome of kidney transplantation. Transplant Proc . 2009;41(2):654-656.
|
| 152 adults (Serbia) |
MMF, Tac, CsA, CS (1 y) |
1188AA: no association with leukopenia |
Perovic et al., 2018Perovic V, Markovic M, Kravljaca M, Milosevic E, Djoric M, Pravica V, et al. Cytokine gene polymorphism profiles in kidney transplant patients - association of +1188A/C RS3212227 SNP in the IL12B gene prevents delayed graft function. Arch Med Res. 2018;49(2):101-108.
|
|
TNF
|
rs1800629 (c.-488G>A, -308G>A)
|
112 adults (Germany) |
MMF, Aza, CsA, CS (1 y) |
-308G>A: no association with AR |
Weimer et al., 2003Weimer R, Mytilineos J, Feustel A, Preiss A, Daniel V, Grimm H, et al. Mycophenolate mofetil-based immunosuppression and cytokine genotypes: effects on monokine secretion and antigen presentation in long-term renal transplant recipients. Transplantation . 2003;75(12):2090-2099.
|
| 100 adults (Canada) |
MMF, Tac, Aza, CsA, CS (1 y) |
-308G>A: no association with AR, graft failure or patient death |
Dmitrienko et al., 2005Dmitrienko S, Hoar DI, Balshaw R, Keown PA. Immune response gene polymorphisms in renal transplant recipients. Transplantation. 2005;80(12):1773-1782.
|
| 63 adults (Venezuela) |
MMF, CsA, CS (3 y) |
-308: no association with AR |
Gendzekhadze et al., 2006Gendzekhadze K, Rivas-Vetencourt P, Montano RF. Risk of adverse post-transplant events after kidney allograft transplantation as predicted by CTLA-4 +49 and TNF- alpha -308 single nucleotide polymorphisms: a preliminary study. Transpl Immunol . 2006;16(3-4):194-199. https://doi.org/10.1016/j.trim.2006.09.001.
https://doi.org/https://doi.org/10.1016/...
|
| 50 adults (Japan) |
MMF, Tac, CS (1 y) |
-308G>A and -238G>A: no association with chronic graft nephropathy |
Satoh et al., 2007Satoh S, Saito M, Inoue K, Miura M, Komatsuda A, Habuchi T. Association of cytokine polymorphisms with subclinical progressive chronic allograft nephropathy in Japanese renal transplant recipients: preliminary study. Int J Urol. 2007;14(11):990-994.
|
| 100 adults (Iran) |
MMF, CsA, CS (1 m) |
-308G>A: no association with AR |
Azarpira et al., 2009Azarpira N, Aghdai MH, Raisjalali GA, Darai M, Tarahi MJ. Influence of recipient and donor IL-10, TNFA and INFG genotypes on the incidence of acute renal allograft rejection. Mol Biol Rep. 2009;36(6):1621-1626.
|
| 231 adults (Tunisia) |
MMF-based ISS therapy (20 y) |
-308G>A: no association with AR or chronic rejection |
Dhaouadi et al., 2013Dhaouadi T, Sfar I, Bardi R, Jendoubi-Ayed S, Abdallah TB, Ayed K, et al. Cytokine gene polymorphisms in kidney transplantation. Transplant Proc . 2013;45(6):2152-2157.
|
| rs361525 (c.-418G>A, -238G>A) |
92 adults (Saudi Arabia) |
MMF, Tac, mTORi, CsA, CS (5 y) |
-308G>A: no association with AR |
Gaafar et al., 2014Gaafar A, Iqniebi A, Sheereen A, Eldali A, Turpeinen H, Adra C, et al. Study of the cytokine polymorphisms in correlation to rejection and graft survival in renal allograft donors and recipients from a homogenous Saudi population. Transpl Immunol. 2014;30(1):34-39.
|
| 247 Hispanic adults (USA) |
MMF or ECMPS, Tac, Srl, CsA, CS (2 y) |
-308G>A: no association with CMV infection |
Vu et al., 2014bVu D, Shah T, Ansari J, Sakharkar P, Yasir Q, Naraghi R, et al. Interferon-gamma gene polymorphism +874 A/T is associated with an increased risk of cytomegalovirus infection among Hispanic renal transplant recipients. Transplant Infect Dis. 2014b;16(5):724-732.
|
| 246 adults (Brazil) |
MMF, Tac, Srl, Aza, CS (6 m) |
-308G>A: no association with AR |
Cilião et al., 2017Cilião HL, Camargo-Godoy RBO, de Souza MF, Dos Reis MB, Iastrenski L, Alvares Delfino VD, et al. Association of UGT2B7, UGT1A9, ABCG2, and IL23R polymorphisms with rejection risk in kidney transplant patients. J Toxicol Environ Health, Part A. 2017;80(13-15):661-671.
|
| 152 adults (Serbia) |
MMF, Tac, CsA, CS (1 y) |
-308G>A: no association with AR, DGF or graft funcion |
Perovic et al., 2018Perovic V, Markovic M, Kravljaca M, Milosevic E, Djoric M, Pravica V, et al. Cytokine gene polymorphism profiles in kidney transplant patients - association of +1188A/C RS3212227 SNP in the IL12B gene prevents delayed graft function. Arch Med Res. 2018;49(2):101-108.
|
| 146 adults (Brazil) |
MMF, Tac, CsA, CS (10 y) |
-308G: no association with IL-6 and IL-10 plasma levels |
Alves et al., 2020Alves LV, Martins SR, Simões E Silva AC, Cardoso CN, Gomes KB, Mota APL. TNF, IL-6, and IL-10 cytokines levels and their polymorphisms in renal function and time after transplantation. Immunol Res. 2020;68(5):246-254.
|
| 154 adults (Australia) |
MMF, Tac, CS (2 w) |
-308G>A: no association with AR |
Hu et al., 2020Hu R, Barratt DT, Coller JK, Sallustio BC, Somogyi AA. No major effect of innate immune genetics on acute kidney rejection in the first 2 weeks post-transplantation. Front Pharmacol. 2020;10:1686.
|
|
IFNG
|
rs2430561 (874T>A, c.115-483A>T) |
100 adults (Canada) |
MMF, Tac, Aza, CsA, CS (1 y) |
STR: no association with AR, graft failure or patient death |
Dmitrienko et al., 2005Dmitrienko S, Hoar DI, Balshaw R, Keown PA. Immune response gene polymorphisms in renal transplant recipients. Transplantation. 2005;80(12):1773-1782.
|
| 63 adults (Venezuela) |
MMF, CsA, CS (3 y) |
874T>A: no association with AR or chronic rejection |
Gendzekhadze et al., 2006Gendzekhadze K, Rivas-Vetencourt P, Montano RF. Risk of adverse post-transplant events after kidney allograft transplantation as predicted by CTLA-4 +49 and TNF- alpha -308 single nucleotide polymorphisms: a preliminary study. Transpl Immunol . 2006;16(3-4):194-199. https://doi.org/10.1016/j.trim.2006.09.001.
https://doi.org/https://doi.org/10.1016/...
|
| rs2069718 A>G (c.367-895T>C) |
50 adults (Japan) |
MMF, Tac, CS (1 y) |
874T>A: no association with chronic graft nephropathy |
Satoh et al., 2007Satoh S, Saito M, Inoue K, Miura M, Komatsuda A, Habuchi T. Association of cytokine polymorphisms with subclinical progressive chronic allograft nephropathy in Japanese renal transplant recipients: preliminary study. Int J Urol. 2007;14(11):990-994.
|
| 100 adults (Iran) |
MMF, CsA, CS (1 m) |
874T>A: no association with AR |
Azarpira et al., 2009Azarpira N, Aghdai MH, Raisjalali GA, Darai M, Tarahi MJ. Influence of recipient and donor IL-10, TNFA and INFG genotypes on the incidence of acute renal allograft rejection. Mol Biol Rep. 2009;36(6):1621-1626.
|
| rs2870953 T>A |
296 adults (India) |
MMF, Tac, CsA, CS (3 y) |
874T>A: no association with AR |
Singh et al., 2009Singh R, Kesarwani P, Ahirwar DK, Kapoor R, Mittal RD. Interleukin 8 -251T>A and Interferon gamma +874A>T polymorphism: potential predictors of allograft outcome in renal transplant recipients from north India. Transpl Immunol . 2009;21(1):13-17.
|
| 231 adults (Tunisia) |
MMF-based ISS therapy (20 y) |
874T>A: no association with AR or chronic rejection |
Dhaouadi et al., 2013Dhaouadi T, Sfar I, Bardi R, Jendoubi-Ayed S, Abdallah TB, Ayed K, et al. Cytokine gene polymorphisms in kidney transplantation. Transplant Proc . 2013;45(6):2152-2157.
|
| rs12369470 T>C |
92 adults (Saudi Arabia) |
MMF, Tac, mTORi, CsA, CS (5 y) |
874T>A: no association with AR |
Gaafar et al., 2014Gaafar A, Iqniebi A, Sheereen A, Eldali A, Turpeinen H, Adra C, et al. Study of the cytokine polymorphisms in correlation to rejection and graft survival in renal allograft donors and recipients from a homogenous Saudi population. Transpl Immunol. 2014;30(1):34-39.
|
| 247 Hispanic adults (USA) |
MMF or ECMPS, Tac, Srl, CsA, CS (3 y) |
874T>A: no association with AR |
Vu et al., 2014bVu D, Shah T, Ansari J, Sakharkar P, Yasir Q, Naraghi R, et al. Interferon-gamma gene polymorphism +874 A/T is associated with an increased risk of cytomegalovirus infection among Hispanic renal transplant recipients. Transplant Infect Dis. 2014b;16(5):724-732.
|
| STR (126-134 bp) |
152 adults (Serbia) |
MMF, Tac, Srl, CsA, CS (1 y) |
874T>A: no association with AR, DGF or graft function |
Perovic et al., 2018Perovic V, Markovic M, Kravljaca M, Milosevic E, Djoric M, Pravica V, et al. Cytokine gene polymorphism profiles in kidney transplant patients - association of +1188A/C RS3212227 SNP in the IL12B gene prevents delayed graft function. Arch Med Res. 2018;49(2):101-108.
|
| 600 adults (Spain) |
MMF, Tac, CS (1 y) |
874T>A: no association with CMV infection |
Santiago et al., 2020Santiago JL, Pérez-Flores I, Sánchez-Pérez L, Moreno de la Higuera MA, Calvo-Romero N, Querol-García J, et al. The Interferon-Gamma +874 A/T polymorphism is not associated with cmv infection after kidney transplantation. Front Immunol. 2020;10:2994.
|
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